Results 121 to 130 of about 33,224 (307)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Nature, 1889 IT may perhaps have occurred to others besides myself that the term “degradation”—as applied to the transmutation, for instance, of mechanical energy into heat energy—is a rather stronger one than our present knowledge warrants us in using: that it casts, in fact, an unmerited slur on the character of that eminently respectable concept energy.
openaire +2 more sources
Cell-wall Polysaccharide Degradability in Divergently Selected Lucerne [PDF]
Effect of selection in lucerne (Medicago sativa L.) for in vitro dry matter disappearance (IVDMD) and acid detergent lignin (ADL) concentration on the degradabillty of cell-wall polysaccharide was investigated, Lucerne lines that had been previously ...
Endres, Craig S +2 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
A METHOD OF MEASURING THE DEGREE OF ORGANIC MATTER DEGRADABILITY
, 2013 A method has been proposed to determine the degree of degradability of any organic material based on the kinetics of its hydrolysis in H2SO4 of the concentration 11.5 mol.l-1 at a temperature of 108 °C.
Jan Vachal +7 more
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Increased Degradability of Cellulose by Dissolution in Cold Alkali
, 2014 To enhance the degradability of cellulosic materials for further industrial purposes, different qualities of cellulose were dissolved in cold sodium hydroxide solution and precipitated by lowering the pH with sulfuric acid. The precipitated cellulose was
Wang, Yan, +5 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Alfalfa stem tissues: Cell wall deposition, composition, and degradability
, 2002 Declining cell wall degradability of alfalfa (Medicago sativa L.) stems with maturation limits the nutritional value of alfalfa for ruminants. This study characterized changes in cell wall concentration, composition, and degradability by rumen microbes ...
H. G. Jung +3 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2013 Hong Duan,1 Hongsheng Yang,1 Yan Xiong,1 Bin Zhang,1 Cheng Ren,1 Li Min,1 Wenli Zhang,1 Yonggang Yan,2 Hong Li,2 Fuxing Pei,1 Chongqi Tu11Department of Orthopedics, 2School of Physical Science and Technology, Sichuan University, Chengdu, People's ...
Xiong Y +10 more
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