Results 101 to 110 of about 33,224 (307)

Predicting Drug Release From Degradable Hydrogels Using Fluorescence Correlation Spectroscopy and Mathematical Modeling

Frontiers in Bioengineering and Biotechnology, 2019
Predicting release from degradable hydrogels is challenging but highly valuable in a multitude of applications such as drug delivery and tissue engineering.
Saahil Sheth, Emily Barnard, Ben Hyatt, Muruhan Rathinam, Silviya Petrova Zustiak   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

EFFECT OF MECHANICAL PROCESSING OF CEREALS ON RUMEN STARCH DEGRADABILITY [PDF]

, 2020
KOPČEKOVÁ, J., ČEREŠŇÁKOVÁ, Z., FĽAK, P., MLYNEKOVÁ, Z.: Eff ect of mechanical processing of ce reals on rumen starch degradability. Acta univ. agric. et silvic. Mendel. Brun., 2010, LVIII, No. 2, pp.
J Kopčeková, P Fľak, Z Čerešňáková, Z Mlyneková   +3 more
core  

Nitrogen degradability and intestinal digestibility of rumen undegraded protein in rapeseed, rapeseed meal and extracted rapeseed meal

Czech Journal of Animal Science, 2007
In this study, nutritive values of rapeseed (R), rapeseed meal-expeller A (RM-A), rapeseed meal-expeller B (RM-B) and extracted rapeseed meal (ERM) were compared.
P. Homolka, J. Harazim, J. Třináctý
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Biochar for Horticultural Rooting Media Improvement: Evaluation of Biochar from Gasification and Slow Pyrolysis

Agronomy, 2017
Peat is used as rooting medium in greenhouse horticulture. Biochar is a sustainable alternative for the use of peat, which will reduce peat derived carbon dioxide emissions.
Chris Blok, Caroline van der Salm, Jantineke Hofland-Zijlstra, Marta Streminska, Barbara Eveleens, Inge Regelink, Lydia Fryda, Rianne Visser   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Degradability, biocompatibility, and osteogenesis of biocomposite scaffolds containing nano magnesium phosphate and wheat protein both in vitro and in vivo for bone regeneration

, 2016
Yan Xia,1 Panyu Zhou,1,* Fei Wang,2 Chao Qiu,2 Panfeng Wang,1 Yuntong Zhang,1 Liming Zhao,3 Shuogui Xu1,2 1Department of Emergency, 2Department of Orthopedics, Changhai Hospital, Second Military Medical University, 3State Key Laboratory of Bioreactor ...
Xia Y, Wang P, Zhao L, Zhou P, Qiu C, Zhang Y, Wang F, Xu S   +7 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source