Results 91 to 100 of about 4,509,963 (335)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
EBioMedicine, 2019 Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases.
Xiaofen Li +5 more
doaj +1 more source
Thermal Degradation on Already Oxidatively Degraded Solutions
Energy Procedia, 2013 AbstractCO2 capture with alkanolamines has been in use since 1930, where 2-ethanolamine (MEA) is the most studied absorbent for post-combustion. In order to prevent degradation, it is important to understand the degradation mechanisms, which in turn requires knowledge of both stoichiometry and kinetics of the reactions and chemical pathways associated ...
Vevelstad, Solrun Johanne +3 more
openaire +2 more sources
New organic matter degradation proxies: Valid in lake systems? [PDF]
, 2004 We determined concentrations and diagenetic state of organic matter in two cores from Lake Zug, Switzerland. To obtain a general picture of organic matter decay in the lake, we measured bulk parameters such as total organic carbon, total nitrogen, and ...
Cowie, G. L. +4 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Soil degradation: a threat to developing-country food security by 2020? [PDF]
Global population in the year 2020 will be a third higher than in 1995, but demand for food and fiber will rise by an even higher proportion, as incomes grow, diets diversify, and urbanization accelerates.
Scherr, Sara J.
core +1 more source
Photochemical Degradation of Malathion [PDF]
, 1978 Completion Report OWRT Agreement No. 14-34-0001-6002 Project No. A-057-ALASThis is the final completion report for a two-year project which began 1 November 1975.
Schneider, Marlys, Smith, G. Warren
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source