Results 81 to 90 of about 4,101,114 (282)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
Nature Communications, 2022 Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally ...
Christiane Kofink +29 more
doaj +1 more source
Simulating Postbuckling Behaviour and Collapse of Stiffened CFRP Panels [PDF]
, 2007 Advanced composite materials are well known for their outstanding potential in weight-related stiffness and strength leading to an ever increasing share in aerospace structural components out of Carbon Fibre Reinforced Plastics (CFRP).
Degenhardt, Richard, Rohwer, Klaus
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
EBioMedicine, 2019 Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases.
Xiaofen Li +5 more
doaj +1 more source
Soil degradation: a threat to developing-country food security by 2020? [PDF]
Global population in the year 2020 will be a third higher than in 1995, but demand for food and fiber will rise by an even higher proportion, as incomes grow, diets diversify, and urbanization accelerates.
Scherr, Sara J.
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Study of the Electrical Conductivity of Al(III) Doped Sr0.6Na0.4SiO3-a
International Journal of Electrochemical Science, 2019 Sr1-xNaxSiO3-0.5x is receiving worldwide attention as the fast oxide ion conductor. Sr0.6Na0.4Si0.9Al0.1O3- a and Sro.6Nao.4SiO3—α were successfully fabricated using a solid state synthesis method and characterized with X-ray diffractometer (XRD) and ...
Ruijuan Shi +3 more
doaj +1 more source
Photochemical Degradation of Malathion [PDF]
, 1978 Completion Report OWRT Agreement No. 14-34-0001-6002 Project No. A-057-ALASThis is the final completion report for a two-year project which began 1 November 1975.
Schneider, Marlys, Smith, G. Warren
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source