Results 91 to 100 of about 137,298 (386)

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Efecto del aceite esencial de Minthostachys verticillata sobre la respuesta inmune de pacientes alérgicos a ácaros del polvo [PDF]

, 2009
El aceite esencial de hojas de M. verticillata fue obtenido por destilación en corriente de vapor y analizado por cromatografía gaseosa. Células mononucleares de sangre periférica de pacientes alérgicos, fueron estimuladas con aceite esencial.
Andrada, Melisa, Cariddi, Laura Noelia, Demo, Mirta Susana, Maldonado, Ana Maria, Moser, Marina, Sabini, Liliana Ines, Zygadlo, Julio Alberto   +6 more
core  

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae [PDF]

, 2014
Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are involved
AA Humbles, AD Doyle, AD Klion, AE O'Connell, AM Galioto, Anita Y. N. Cheung, Ashleigh C. Johnston, BA Vallance, CA Gray, CA Gray, CS Enobe, D Abraham, D Voehringer, DR Herbert, E Pearlman, E Pinelli, EA Jacobsen, Emma T. Cadman, ET Cadman, H Kita, James J. Lee, JE Simons, JE Simons, JH Schroeder, JJ Lee, Katherine A. Thysse, KJ Hamann, KL Denzler, KL Denzler, L Le Goff, L O'Bryan, LA Spencer, LR Hall, M Lomask, M Witzenrath, ML Knott, PC Fulkerson, PL Milton, RA Lawrence, RA Lawrence, Rachel A. Lawrence, RK Mehlotra, S Pegorier, S Specht, SA Babayan, SI Ochkur, Siobhan Bearder, T Carter, T Ramalingam, T Ramalingam, Thomas B. Nutman, V Fabre, W Mitzner   +52 more
core   +3 more sources

Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor

PLoS ONE, 2016
Engineered nanomaterial (ENM)-mediated toxicity often involves triggering immune responses. Mast cells can regulate both innate and adaptive immune responses and are key effectors in allergic diseases and inflammation.
N. Alsaleh, I. Persaud, Jared M Brown
semanticscholar   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen   +13 more
wiley   +1 more source

Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Frontiers in Cellular Neuroscience, 2019
Extracellular ATP activates inflammasome and triggers the release of multiple cytokines in various immune cells, a process primarily mediated by P2X7 receptors.
Dilyara Nurkhametova, Dilyara Nurkhametova, Igor Kudryavtsev, Igor Kudryavtsev, Valeriia Guselnikova, Valeriia Guselnikova, Maria Serebryakova, Raisa R. Giniatullina, Sara Wojciechowski, Fatma Tore, Albert Rizvanov, Jari Koistinaho, Jari Koistinaho, Tarja Malm, Rashid Giniatullin, Rashid Giniatullin   +15 more
doaj   +1 more source

Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis

Frontiers in Immunology, 2020
Studies have endeavored to understand the cause for impaired antimicrobial killing by neutrophils of people with cystic fibrosis (PWCF). The aim of this study was to focus on the bacterial phagosome.
Elaine Hayes, Mark P. Murphy, Kerstin Pohl, Niall Browne, Karen McQuillan, Le Er Saw, Clare Foley, Fatma Gargoum, Oliver J. McElvaney, Padraig Hawkins, Cedric Gunaratnam, Noel G. McElvaney, Emer P. Reeves   +12 more
doaj   +1 more source

Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions [PDF]

, 2018
Eosinophilic gastrointestinal disorders are a set of conditions with a wide range of clinical manifestations and treatment modalities. The disorders are suspected to result from an abnormal inflammatory response to allergen(s), and individuals may ...
Gupta, Sandeep K., Naramore, Sara
core   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, EarlyView.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis

Toxins, 2019
Garcinol, an anti-inflammatory and anti-carcinogenic polyisoprenylated benzophenone isolated from Garcinia plants, stimulates tumor cell apoptosis and suicidal erythrocyte death, but supports the survival of hepatocytes and neurons.
Hang Cao, Abdulla Al Mamun Bhuyan, Anja T. Umbach, Ke Ma, Oliver Borst, Meinrad Gawaz, Shaqiu Zhang, Bernd Nürnberg, Florian Lang   +8 more
doaj   +1 more source