Results 101 to 110 of about 137,298 (386)

Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms [PDF]

, 2017
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal ...
Agostini, Marco, Alfieri, Rita, Cagol, Matteo, Castagliuolo, Ignazio, Castoro, Carlo, Cavallin, Francesco, Fassan, Matteo, Kotsafti, Andromachi, Nardi, Teresa, Pinto, Eleonora, Rugge, Massimo, Scarpa, Marco, Scarpa, Melania   +12 more
core   +1 more source

P2X7 receptors induce degranulation in human mast cells

Purinergic Signalling Purinergic Signalling, 2016
Mast cells play important roles in host defence against pathogens, as well as being a key effector cell in diseases with an allergic basis such as asthma and an increasing list of other chronic inflammatory conditions.
K. Wareham, E. Seward
semanticscholar   +1 more source

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, Lei‐Bo Xu   +10 more
wiley   +1 more source

Inhibitory effects of pemirolast potassium and FK506 on degranulation and IL-8 production of eosinophils

Allergology International, 1999
Eosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-allergic drug) and FK506 (immunosupressant) on eosinophil ...
Naomi Yamashita, Yasuko Akimoto, Kenji Minoguchi, Kentaro Sekine, Mikio Nakajima, Yuji Okano, Ken Ohta, Tsuyoshi Sakane   +7 more
doaj   +1 more source

抗原および抗ヒトIgEに対する好塩基球の反応性. 1.好塩基球数の変化 [PDF]

, 1992
Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood.
Kimura, Ikuro, Tanizaki, Yoshiro
core   +1 more source

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, EarlyView.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

Eosinophil extracellular traps in respiratory ailment: Pathogenic mechanisms and clinical translation

World Journal of Otorhinolaryngology-Head and Neck Surgery
Background Eosinophilic extracellular traps (EETs) are reticular complexes comprising deoxyribonucleic‐Acid (DNA) fibers and granule proteins. Aims EETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under ...
Shun‐Yu Wu, Bo‐Yu Cai, Tian‐Yu Wang, Zhi‐Wen Cao, Hu Peng, Huan‐Hai Liu   +5 more
doaj   +1 more source

Memory NK cell features exploitable in anticancer immunotherapy [PDF]

, 2019
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone, Capuano, Cristina, Galandrini, Ricciarda, Palmieri, Gabriella, Pighi, Chiara, Santoni, Angela   +5 more
core   +2 more sources

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

Advanced Science, EarlyView.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li, Weijia Chen, Mengxue Sun, Xinbo Ni, Qishan Ran, Xiaoyu Hu, Fang Cao, Wenwen Zeng   +7 more
wiley   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source