Results 101 to 110 of about 116,525 (341)

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae [PDF]

, 2014
Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are involved
AA Humbles, AD Doyle, AD Klion, AE O'Connell, AM Galioto, Anita Y. N. Cheung, Ashleigh C. Johnston, BA Vallance, CA Gray, CA Gray, CS Enobe, D Abraham, D Voehringer, DR Herbert, E Pearlman, E Pinelli, EA Jacobsen, Emma T. Cadman, ET Cadman, H Kita, James J. Lee, JE Simons, JE Simons, JH Schroeder, JJ Lee, Katherine A. Thysse, KJ Hamann, KL Denzler, KL Denzler, L Le Goff, L O'Bryan, LA Spencer, LR Hall, M Lomask, M Witzenrath, ML Knott, PC Fulkerson, PL Milton, RA Lawrence, RA Lawrence, Rachel A. Lawrence, RK Mehlotra, S Pegorier, S Specht, SA Babayan, SI Ochkur, Siobhan Bearder, T Carter, T Ramalingam, T Ramalingam, Thomas B. Nutman, V Fabre, W Mitzner   +52 more
core   +4 more sources

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, EarlyView.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

CREB Is Critically Implicated in Skin Mast Cell Degranulation Elicited via FcεRI and MRGPRX2

Cells
Skin mast cells (MCs) mediate acute allergic reactions in the cutaneous environment and contribute to chronic dermatoses, including urticaria, and atopic or contact dermatitis.
Zhuoran Li, Jean Schneikert, Shiva Raj Tripathi, Manqiu Jin, Gürkan Bal, Torsten Zuberbier, Magda Babina   +6 more
doaj   +1 more source

Inhibitory effects of pemirolast potassium and FK506 on degranulation and IL-8 production of eosinophils

Allergology International, 1999
Eosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-allergic drug) and FK506 (immunosupressant) on eosinophil ...
Naomi Yamashita, Yasuko Akimoto, Kenji Minoguchi, Kentaro Sekine, Mikio Nakajima, Yuji Okano, Ken Ohta, Tsuyoshi Sakane   +7 more
doaj   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells. [PDF]

, 1983
We have examined the morphology, cytochemistry, and biochemistry of mouse leukocyte subsets by analyzing cloned leukocyte populations specialized to perform different immunologic functions.
Cantor, H, der Simonian, H, Dvorak, AM, Dvorak, HF, Galli, SJ, Goldin, J, Marcum, JA, Monahan, RA, Nabel, G, Pyne, K, Rosenberg, RD   +10 more
core  

Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms [PDF]

, 2017
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal ...
Agostini, Marco, Alfieri, Rita, Cagol, Matteo, Castagliuolo, Ignazio, Castoro, Carlo, Cavallin, Francesco, Fassan, Matteo, Kotsafti, Andromachi, Nardi, Teresa, Pinto, Eleonora, Rugge, Massimo, Scarpa, Marco, Scarpa, Melania   +12 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia

Frontiers in Cellular and Infection Microbiology
SARS-CoV-2–induced excessive inflammation in brain leads to damage of blood–brain barrier, hypoxic-ischemic injury, and neuron degeneration. The production of inflammatory cytokines by brain microvascular endothelial cells and microglia is reported to be
Meng-Li Wu, Chengzuo Xie, Chengzuo Xie, Xin Li, Jing Sun, Jincun Zhao, Jian-Hua Wang, Jian-Hua Wang, Jian-Hua Wang   +8 more
doaj   +1 more source

Role of female sex hormones, estradiol and progesterone, in mast cell behaviour

Frontiers in Immunology, 2012
Female sex hormones have long been suspected to have an effect on mast cell (MC) behaviour. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different
Oliver eZierau, Ana Claudia Zenclussen, Federico eJensen   +2 more
doaj   +1 more source