Results 151 to 160 of about 137,298 (386)

MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities [PDF]

, 2020
Marc A. Lafleur, Jonathan Werner, Madeline Fort, Edward K. Lobenhofer, Mercedesz Balázs, Ana Goyos   +5 more
openalex   +1 more source

Comment on “Gas Bubbles From Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation”

Advanced Science, EarlyView.
Lian Cui, Jiangluyi Cai, Hengli Lu, Xincheng Huang, Yuling Shi, Chunyuan Guo   +5 more
wiley   +1 more source

Inflammation and genetics in myo‐pericardial diseases: Insights from the Italian Study Group on Cardiomyopathies and Pericardial Diseases

ESC Heart Failure, EarlyView.
Proposed management of myo‐pericardial diseases. A systematic interdisciplinary approach to myo‐pericardial disease is essential to reach a correct diagnosis, starting from multiparametric characterization including EKG, echocardiography with GLS, laboratory exams and CMR or, in case of electric or haemodynamic instability, EMB.
Marco Merlo, Giulia Bassetto, Antonio Cannatà, Alberto Aimo, Camillo Autore, Barbara Bauce, Elena Biagini, Francesco Cappelli, Silvia Castelletti, Flavio D'Ascenzi, Cesare de Gregorio, Giuseppe Limongelli, Francesca Marzo, Beatrice Musumeci, Giacomo Tini, Roberto Pedrinelli, Pasquale Perrone Filardi, Gianfranco Sinagra, Massimo Imazio   +18 more
wiley   +1 more source

Degranulation of mast cells in dengue patients [PDF]

, 2002
Ludmila V. Asher, Aimie Norton, Stephen J. Krivda, Henry K. Wong, M. P. Mammen, Arthur Lyons, Stephen J. Thomas, Wellington Sun, Kenneth H. Eckels, David W. Vaughn   +9 more
openalex   +1 more source

Transcriptomic and proteomic profiling shows dysregulated immune and metabolic pathways in arrhythmogenic cardiomyopathy

ESC Heart Failure, EarlyView.
Abstract Aims Arrhythmogenic cardiomyopathy (ACM) is a hereditary heart disease characterized by fibrofatty myocardial replacement and a predisposition to malignant ventricular arrhythmias. The underlying pathomechanisms remain incompletely understood, and specific disease markers are sparse.
Deniz Akdis, Lukas Weidmann, Paolo Nanni, Anna Gaertner, Hendrik Milting, Peter Bode, Corinna Brunckhorst, Liang Chen, Felix C. Tanner, Frank Ruschitzka, Ardan M. Saguner, Firat Duru   +11 more
wiley   +1 more source

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

, 2021
Tomohiro Nizawa, Imran Ahmed Bhutto, Anupama Tiwari, Rhonda Grebe, Jesse Alt, Rana Rais, Malia M. Edwards, Gerard A. Lutty   +7 more
openalex   +1 more source

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, EarlyView.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

Mechanical stress-induced mast cell degranulation activates TGFβ-1 signalling pathway in pulmonary fibrosis [PDF]

, 2016
Chiko Shimbori, Pierre‐Simon Bellaye, Chandak Upagupta, Jack Gauldie, Martin Kolb   +4 more
openalex   +1 more source

Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis

iMetaMed, EarlyView.
Integrative analysis of LC‐PTB patients pinpoints six biomarkers (ANK2, EPB42, CA1, HBB, HBD, MYL4) that reshape the immune microenvironment, offering new targets for diagnosis and treatment of lung cancer complicated by tuberculosis. ABSTRACT Coexisting lung cancer and pulmonary tuberculosis (LC‐PTB) is clinically challenging in diagnosis and ...
Ling Yang, Shanshan Li, Guangliang Bai, Longyan Li, Yuxi Li, Xuejiao Liang, Zhaoyang Ye, Linsheng Li, Li Zhuang, Jingzhi Guan, Wenping Gong   +10 more
wiley   +1 more source

Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A‐YTHDF2‐dependent mechanism

iMeta, EarlyView.
Homoharringtonine (HHT), a clinically approved anti‐leukemic drug, directly binds the RNA‐binding protein EWSR1. HHT induces an allosteric conformational switch in the RNA recognition motif of EWSR1, driving self‐association and liquid–liquid phase separation (LLPS). The resulting condensates act as regulatory hubs that sequester the m6A reader YTHDF2,
Ting‐Ting Liu, Li‐Ting Chen, Xu‐Ying Pei, Shao‐Nan Hu, Fang‐Fang Zhuo, Ze‐Kun Chen, Yang Liu, Jing‐Kang Wang, Ji‐Chao Zhang, Qi Cao, Ling Li, Jing Wang, Tian‐Tian Wei, Bo Han, Peng‐Fei Tu, Xiang‐Yu Zhao, Ruidong Xue, Ke‐Wu Zeng   +17 more
wiley   +1 more source