Results 151 to 160 of about 87,250 (304)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Molecular Heterogeneity in Clinically Ambiguous Atopic Dermatitis–Psoriasis Overlap: Compartment‐Resolved Transcriptomic Profiling

Allergy, EarlyView.
Compartment‐resolved transcriptomic profiling of AD, PsO, and clinically ambiguous AD‐PsO overlap lesions reveals molecular heterogeneity, with overlap lesions showing relative alignment toward AD‐like or PsO‐like patterns. AD‐like alignment is associated with epidermal barrier and dermal neural/sensory pathways, whereas PsO‐like alignment is ...
Jongeun Lee, Yookyung Sophie Chun, Hyo Jeong Nam, Yun Jung Huh, Jaehwan Kim, James G. Krueger, Seung Sam Paik, Hyun Je Kim, Seon‐Pil Jin, Jeong Eun Kim   +9 more
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Eosinophilia Reflects Type 2 Immune Activation in Newly Diagnosed Bullous Pemphigoid, With No Evidence of Charcot‐Leyden Crystals

Allergy, EarlyView.
Janik Fleißner, Tassilo Dege, Sandrine Benoit, Matthias Goebeler, Andreas Kerstan   +4 more
wiley   +1 more source

European Guidelines on Eosinophilic Esophagitis: Evidence‐Based Statements and Recommendations for Diagnosis and Management in Children and Adults. Part 1: Diagnosis, Epidemiology and Natural History

Allergy, EarlyView.
The European evidence‐based guidelines on eosinophilic esophagitis (Part 1). This infographic summarizes the methodological framework and core clinical outputs of the updated consensus developed by multidisciplinary experts from EUREOS, EAACI, ESPGHAN, and ESP.
Alfredo J. Lucendo, Javier Molina‐Infante, Ángel Arias, Ulrike von Arnim, Henrik Bergquist, Luc Biedermann, Albert J. Bredenoord, Marie Carlson, Javier Chahuan, Jorge Amil Dias, Thomas Eiwegger, Sara Feo‐Ortega, Sandra L. Garcia‐Dionisio, Matteo Ghisa, Jesús González‐Cervera, Thomas Greuter, Danila Guagnozzi, Carolina Gutiérrez‐Junquera, Lucía Gutiérrez‐Ramírez, Cord Langner, Helen Larsson, Anne Lund Krarup, Salvatore Oliva, Alexandra Papadopoulou, Francesca Racca, Cecilio Santander, Edoardo Vincenzo Savarino, Christoph Schlag, Alain M. Schoepfer, Martin A. Storr, Antonio Tejera‐Muñoz, Noam Zevit, Stephen E. Attwood, Alex Straumann   +33 more
wiley   +1 more source

Single‐Cell Omics Profiling Reveals Enhanced Heterogeneity of Cord Blood Basophils at Birth

Allergy, EarlyView.
Cord basophils exhibit greater heterogeneity and diverse functional states relative to maternal basophils. Maternal and cord blood basophils have different transcriptomics and functional profiles. Cord basophil exhibits earlier pseudotime than maternal basophil, potentially indicating a more naïve state.
Jing Hui Low, Xiaohui Man, Jocelyn Ong, Anna de Beer, Sofia Papavasileiou, Srinidhi Sudharson, Seohyun Kim, Yiping Fan, Hui Hua Liew, Alicia Tay, Shihui Foo, Shanshan W. Howland, Joakim S. Dahlin, Florent Ginhoux, Jerry Kok Yen Chan, Anand Kumar Andiappan   +15 more
wiley   +1 more source

An Extended Transcriptomic Landscape of Human Skin Mast Cells: Unveiling Lineage‐Specific Noncoding RNA Dynamics in FcεRI Activation

Allergy, EarlyView.
FcεRI cross‐linking triggers widespread transcriptional reprogramming in human skin mast cells (> 5000 genes, > 6400 promoters, and 48 novel mast cell‐enriched lncRNAs). Breast skin and foreskin mast cells share core transcriptional programs but differ selectively in tryptase isoenzymes and IL‐8/IL‐1RA release.
Gürkan Bal, Kristin Franke, Stefan Frischbutter, Shiva Raj Tripathi, Kayoko Yasuzawa, Jordan A. Ramilowski, Michihira Tagami, Takeya Kasukawa, Michiel de Hoon, Jay W. Shin, Piero Carninci, Torsten Zuberbier, Magda Babina   +12 more
wiley   +1 more source

Compartmentalized and Differential Regulation of NK- and γδ T-Cell Degranulation by Trophoblast-Derived Signals During Early Pregnancy. [PDF]

Cells
Ivanova M, Alexandrova M, Parvanov D, Manchorova D, Terzieva A, Vangelov I, Kirilov K, Dimova T.   +7 more
europepmc   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Shared mediators, divergent networks: a tissue-response hypothesis for discordant phenotypes in chronic spontaneous urticaria and atopic dermatitis. [PDF]

Front Allergy
Ye YM, Hide M.
europepmc   +1 more source