Results 71 to 80 of about 4,816,964 (328)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
A degree theory for a class of perturbed Fredholm maps
Fixed Point Theory and Applications, 2005 We define a notion of degree for a class of perturbations of nonlinear Fredholm maps of index zero between infinite-dimensional real Banach spaces. Our notion extends the degree introduced by Nussbaum for locally α-contractive perturbations of the ...
Massimo Furi +2 more
doaj +2 more sources
Coexistence of steady state for a diffusive prey-predator model with harvesting
Electronic Journal of Differential Equations, 2016 In this article, we study a diffusive prey-predator model with modified Leslie-Gower term and Michaelis-Menten type prey harvesting, subject to homogeneous Dirichlet boundary conditions.
Yan Li
doaj
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Variational inequalities with the duality operator in Banach spaces
Results in Nonlinear Analysis, 2020 We study variational inequality by way of metric projection in Banach spaces. The main method is to use a topological degree theory for the class of operators of monotone type in Banach spaces. More precisely, some variational inequality associated with
In-Sook Kim
doaj
Degree Theory Beyond Continuous Maps [PDF]
, 1996 The author gives an introductory overview (without proofs) on recent extensions of finite-dimensional degree theory to the non-continuous case. This is of particular interest in dealing with the Ginzburg-Landau equations. Let \(X,Y\) be compact connected Riemannian manifolds of the same dimension with \(Y\) smoothly embedded in some \(\mathbb{R}^{N}\).
openaire +2 more sources
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Robust feasibility of systems of quadratic equations using topological degree theory [PDF]
, 2023 Krishnamurthy Dvijotham +3 more
openalex +1 more source