Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Myocarditis is characterized by inflammatory cell infiltration in myocardial stroma. Attenuation of tumor necrosis factor (TNF)-α and interleukin (IL)-1β is a reliable mark for improving the prognosis.
Shanshan Li +10 more
doaj +3 more sources
Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat. [PDF]
PLoS ONE, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Patrick Paulus +8 more
doaj +5 more sources
Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis [PDF]
Cell Death and DiseaseRadioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in lung cancer and that FBXO22 knockdown increased the ...
Yunshang Chen +12 more
doaj +2 more sources
The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts [PDF]
Viruses, 2018 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells.
Masatoshi Nukui +2 more
doaj +3 more sources
Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation [PDF]
Cell Death and DiseaseCutaneous squamous carcinoma is the second most common epithelial malignancy, associated with significant morbidity, mortality, and economic burden. However, the mechanisms underlying cSCC remain poorly understood.
Kaili Zhou +10 more
doaj +2 more sources
Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on “The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts” [PDF]
Viruses, 2019 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes a lifelong persistence in the host through both chronic and latent states of infection [...]
Beatrice Mercorelli +4 more
doaj +3 more sources
Inhibitory Effects of B‑, C‑, and E‑Ring-Truncated Deguelin Derivatives Against A549, HCT116, and MCF‑7 Cancer Cells [PDF]
ACS Omega, 2023 John Alfon P. Francisco +1 more
doaj +2 more sources
Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway. [PDF]
Dis Markers, 2022 Non‐small‐cell lung cancer (NSCLC) is the most common lung cancer and a major cause of cancer mortality worldwide. Deguelin plays a vital inhibitory role in NSCLC initiation and development. However, the downstream mechanism of deguelin‐suppressed metastasis of NSCLC cells is still not completely understood.
Lu G, Yao Y, Zhang X, Cui D, Zhou J.
europepmc +2 more sources
Novel insights into immunopathogenesis and crucial biomarkers between primary open-angle glaucoma and systemic lupus erythematosus. [PDF]
IMetaOmicsThis study revealed a novel correlation between systemic lupus erythematosus (SLE) and primary open‐angle glaucoma (POAG) through comprehensive bioinformatics analysis and experimentation, identifying biomarkers and immunopathogenesis for future research and treatment of SLE‐related POAG.
Liu Y +5 more
europepmc +2 more sources
BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. [PDF]
PLoS ONE, 2016 This study has been undertaken to explore the therapeutic effects of deguelin and specific siRNAs in HeLa cells. The data provided clearly show the silencing of ERK 1/2 with siRNAs and inhibition of ERK1/2 with deguelin treatment in HeLa cells ...
Samra Hafeez +15 more
doaj +1 more source