Results 71 to 80 of about 1,629 (181)
PI3K/Akt pathway: a potential therapeutic target for chronic pain [PDF]
, 2017 Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms.
Chen, Shu-Ping +8 more
core +1 more source
Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis
Oncology Reports, 2008 Deguelin is a rotenoid isolated from several plant species, which has been reported to have chemopreventive effects in skin, mammary, colon and lung cancers. The effects of deguelin on the proliferation and apoptosis of hepatic cancer cells were assessed by MTT assay and flow cytometric analysis.
Ju-Hee, Lee +5 more
openaire +3 more sources
Chemistry &Biodiversity, Volume 21, Issue 4, April 2024.Abstract This perspective delves into the investigation of synthetic and naturally occurring inhibitors, their patterns of inhibition, and the effectiveness of newly utilized natural compounds as inhibitors targeting the Ornithine decarboxylase enzyme. This enzyme is known to target the MYC oncogene, thereby establishing a connection between polyamine ...
Preeti Nanda Sahu, Anik Sen
wiley +1 more source
Brown Stink Bug Mortality by Seed Extracts of Tephrosia Vogelii Containing Deguelin and Tephrosin
Brazilian Archives of Biology and Technology, 2018 Extracts of the seeds of Tephrosia vogelii Hook. f. were studied in relation to its chemical composition and toxicity to the brown stink bug Euschistus heros (F.).
Adriana Yatie Mikami +2 more
doaj +1 more source
Heat shock protein 90: biological functions, diseases, and therapeutic targets
MedComm, Volume 5, Issue 2, February 2024.Targeting the dynamic cycling of HSP90 and its interaction with co‐chaperones can promote protein maturation and client protein degradation, potentially offering effective antineoplastic strategies. Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and ...
Huiyun Wei +7 more
wiley +1 more source
Química Nova, 2012 In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers ...
Jackson Nunes e Vasconcelos +10 more
doaj +1 more source
ChemistryOpen, Volume 13, Issue 1, January 2024.Rotenone derivatives were synthesized through modifications of the carbonyl group and their antiproliferative activities were evaluated against various cancer cell lines (MCF‐7, A549, and HCT116). The physicochemical properties and drug‐likeness of the derivatives were evaluated using the SwissADME webtool.
Rajelle D. Hernandez +4 more
wiley +1 more source
A New Prenylated Flavanone from Derris trifoliata Lour.
Molecules, 2012 A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro ...
Hao Yin +7 more
doaj +1 more source
Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
The FASEB Journal, 2017 ABSTRACT As a result of limited classes of anthelmintics and an over‐reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant‐derived rotenoid, selectively and potently inhibits the motility and development ...
Preston, S +19 more
openaire +3 more sources
Molecules, 2016 The species Deguelia utilis and Deguelia rufescens var. urucu, popularly known as “timbó,” have been used for many years as rotenone sources in insecticide formulations.
Danielle da Costa +8 more
doaj +1 more source