Results 71 to 80 of about 1,616 (183)

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols [PDF]

, 2010
Background: Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NF-kappa B, AP1 and Nrf2 transcription ...
Wipob Suttana, Samlee Mankhetkorn, Wilart Poompimon, Ajay Palagani, Sergey Zhokhov, Sarah Gerlo, Guy Haegeman, Wim Berghe   +7 more
core   +2 more sources

Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis

Oncology Reports, 2008
Deguelin is a rotenoid isolated from several plant species, which has been reported to have chemopreventive effects in skin, mammary, colon and lung cancers. The effects of deguelin on the proliferation and apoptosis of hepatic cancer cells were assessed by MTT assay and flow cytometric analysis.
Ju-Hee, Lee, Don-Haeng, Lee, Hyun-Seung, Lee, Joon-Seok, Choi, Kyu-Won, Kim, Soon-Sun, Hong   +5 more
openaire   +3 more sources

Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review

Food Science &Nutrition, Volume 12, Issue 5, Page 3025-3045, May 2024.
Polyphenols, such as kaempferol, catechins, apigenin, chlorogenic acid, rosmarinic acid, and caffeic acid, have shown their ability to serve as potential antidiabetic medicines. Also, the use of polyphenols might have a few side effects although relatively less than available medications. Abstract In the middle of an ever‐changing landscape of diabetes
Dipa Aryal, Soniya Joshi, Nabin Kumar Thapa, Pratiksha Chaudhary, Sirjana Basaula, Usha Joshi, Damodar Bhandari, Hannah M. Rogers, Salyan Bhattarai, Khaga Raj Sharma, Bishnu P. Regmi, Niranjan Parajuli   +11 more
wiley   +1 more source

Preventing Cancer by Inhibiting Ornithine Decarboxylase: A Comparative Perspective on Synthetic vs. Natural Drugs

Chemistry &Biodiversity, Volume 21, Issue 4, April 2024.
Abstract This perspective delves into the investigation of synthetic and naturally occurring inhibitors, their patterns of inhibition, and the effectiveness of newly utilized natural compounds as inhibitors targeting the Ornithine decarboxylase enzyme. This enzyme is known to target the MYC oncogene, thereby establishing a connection between polyamine ...
Preeti Nanda Sahu, Anik Sen
wiley   +1 more source

Brown Stink Bug Mortality by Seed Extracts of Tephrosia Vogelii Containing Deguelin and Tephrosin

Brazilian Archives of Biology and Technology, 2018
Extracts of the seeds of Tephrosia vogelii Hook. f. were studied in relation to its chemical composition and toxicity to the brown stink bug Euschistus heros (F.).
Adriana Yatie Mikami, Maurício Ursi Ventura, Cesar Cornelio Andrei   +2 more
doaj   +1 more source

Penggunaan Pestisida Biorasional untuk Mengendalikan Hama dan Penyakit Penting pada Tanaman Kentang [PDF]

, 2008
Percobaan lapang dengan tujuan untuk mengendalikan hama dan penyakit penting pada tanaman kentang menggunakan pestisida biorasional dilaksanakan dari bulan April sampai Juli 2002 di Kebun Percobaan Margahayu (elevasi 1.250 m dpl), Lembang, Bandung, Jawa ...
Suryaningsih, E. (Euis)
core   +2 more sources

Heat shock protein 90: biological functions, diseases, and therapeutic targets

MedComm, Volume 5, Issue 2, February 2024.
Targeting the dynamic cycling of HSP90 and its interaction with co‐chaperones can promote protein maturation and client protein degradation, potentially offering effective antineoplastic strategies. Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and ...
Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Aniruddha Chatterjee, Pengxing He, Guiqin Hou   +7 more
wiley   +1 more source

Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

Química Nova, 2012
In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers ...
Jackson Nunes e Vasconcelos, Gilvandete Maria Pinheiro Santiago, Jefferson Queiroz Lima, Jair Mafezoli, Telma Leda Gomes de Lemos, Francisca Renata Lopes da Silva, Mary Anne Sousa Lima, Antônia Torres Ávila Pimenta, Raimundo Braz-Filho, Angela Martha Campos Arriaga, Dari Cesarin-Sobrinho   +10 more
doaj   +1 more source

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

The FASEB Journal, 2017
ABSTRACT As a result of limited classes of anthelmintics and an over‐reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant‐derived rotenoid, selectively and potently inhibits the motility and development ...
Preston, S, Korhonen, PK, Mouchiroud, L, Cornaglia, M, McGee, SL, Young, ND, Davis, RA, Crawford, S, Nowell, C, Ansell, BRE, Fisher, GM, Andrews, KT, Chang, BCH, Gijs, MAM, Sternberg, PW, Auwerx, J, Baell, J, Hofmann, A, Jabbar, A, Gasser, RB   +19 more
openaire   +3 more sources

Antiproliferative Activities and SwissADME Predictions of Physicochemical Properties of Carbonyl Group‐Modified Rotenone Analogues

ChemistryOpen, Volume 13, Issue 1, January 2024.
Rotenone derivatives were synthesized through modifications of the carbonyl group and their antiproliferative activities were evaluated against various cancer cell lines (MCF‐7, A549, and HCT116). The physicochemical properties and drug‐likeness of the derivatives were evaluated using the SwissADME webtool.
Rajelle D. Hernandez, Frances Abygail F. Genio, Jannelle R. Casanova, Marlon T. Conato, Monissa C. Paderes   +4 more
wiley   +1 more source