Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives
Pharmacological Research, 2005 Dehydroabietic acid derivatives have been reported to display antisecretory and antipepsin effect in animal models. Some 19 dehydroabietic acid diterpenes were prepared and assessed for gastroprotective activity in the HCl/EtOH-induced gastric lesions in mice as well as for cytotoxicity in human lung fibroblasts (MRC-5) and human epithelial gastric ...
Cristina Theoduloz +1 more
exaly +5 more sources
Synthesis and anti-inflammatory activity of novel 1,2,3-triazole- derivatives from 7-Oxodehydroabietic acid [PDF]
BMC ChemistryDehydroabietic acid (DHA) is a naturally occurring diterpene with relevant biological activities. 7-Oxodehydroabietic acid as a highly oxidized state derivative from Dehydroabietic acid (DHA) showing good activities.
Yong-Feng Lv +5 more
doaj +2 more sources
Synthesis and biological evaluation of novel N-(piperazin-1-yl)alkyl-1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential MEK inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 In this paper, a series of novel 1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid bearing different N-(piperazin-1-yl)alkyl side chains were designed, synthesised and evaluated for their in vitro anticancer activities against three human ...
Hao Chen +5 more
doaj +2 more sources
Dehydroabietic Acid Isolated from Commiphora opobalsamum Causes Endothelium-Dependent Relaxation of Pulmonary Artery via PI3K/Akt-eNOS Signaling Pathway [PDF]
Molecules, 2014 Commiphora opobalsamum is a Traditional Chinese Medicine used to treat traumatic injury, mainly by relaxing blood vessels. In this study, two diterpenes, dehydroabietic acid (DA) and sandaracopimaric acid (SA) were obtained from it by a bioassay-guided ...
Wenyan Gao +8 more
doaj +2 more sources
Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. [PDF]
Int J Mol Sci, 2019 Kim E +9 more
europepmc +2 more sources
Ice core records of levoglucosan and dehydroabietic and vanillic acids from Aurora Peak in Alaska since the 1660s: a proxy signal of biomass-burning activities in the North Pacific Rim [PDF]
Atmospheric Chemistry and Physics, 2020 A 180 m long (343 years) ice core was drilled in the saddle of Aurora Peak in Alaska (63.52∘ N, 146.54∘ W; elevation: 2825 m) and studied for biomass-burning tracers.
A. Pokhrel +11 more
doaj +1 more source
Plants, 2021 In this work, the sawmill waste from Picea abies debarking was considered as source of valuable phytoconstituents. The extraction was performed using different ethanol/water mixtures, and characterization was obtained by LC-MSn.
Stefania Sut +9 more
doaj +1 more source
Dehydroabietic acid as a biomarker for exposure to colophony [PDF]
Occupational Medicine, 2007 Colophony (rosin) is a natural product derived from the resin of coniferous trees with many industrial applications including soldering fluxes. Exposure to colophony fume through soldering is one of the leading causes of occupational asthma in the UK.To assess occupational exposure to colophony from solder fume at selected workplaces in the UK and to ...
Peter E J, Baldwin +4 more
openaire +2 more sources
NITRATION OF DEHYDROABIETIC ACID DERIVATIVES [PDF]
Chemistry Letters, 1973 Abstract Nitration of various dehydroabietic acid derivatives was examined and it was found that nitration was affected by the structure. An interesting substitution occurred at 11,13 (deisopropylation) and 14 positions.
Yasuo Ohtsuka +2 more
openaire +1 more source
Molecular diversity, 2023 In an attempt to search for new natural product-based antitumor agents, a series of novel thiazolidinone derivatives of dehydroabietic acid-based B ring-fused-thiazole were designed and synthesized.
N. Chen, Cui-Ping Li, Hong-Fei Huang
semanticscholar +1 more source