Results 171 to 180 of about 266,371 (307)

Natural Killer Subset Changes and Vascular Endothelial Growth Factor‐A Plasma Profile in Progressive Supranuclear Palsy: The NKscape Study

Movement Disorders, EarlyView.
Abstract Background Emerging evidence implicates neuroinflammation in progressive supranuclear palsy (PSP) pathophysiology, with elevated cyto‐chemokines suggesting natural killer (NK) cell involvement. Methods We characterized peripheral NK in PSP (N = 11) versus Parkinson's disease (PD, N = 10) and healthy controls (HC, N = 8) at both ...
Marina Picillo, Cristina Basile, Francesco Montella, Valentina Lopardo, Mariangela Orlando, Roberta Tarallo, Domenico Palumbo, Viola Melone, Maria Francesca Tepedino, Paolo Barone, Annibale Alessandro Puca, Elena Ciaglia   +11 more
wiley   +1 more source

The impact of antidiabetic drugs on dementia risk: a Bayesian network meta-analysis. [PDF]

Front Endocrinol (Lausanne)
Yu Y, Peng X, Su C, Bai Y, Hou D.
europepmc   +1 more source

Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7‐Year Prospective Matched Cohort Study

Movement Disorders, EarlyView.
Abstract Background Although clinical markers (eg, motor and cognitive impairment) in isolated rapid eye movement sleep behavior disorder (iRBD) are associated with faster phenoconversion, their longitudinal trajectory patterns (linear or nonlinear) remain unclear.
Li Zhou, Yaping Liu, Bei Huang, Jing Wang, Shi Tang, Yuhua Yang, Siyi Gong, Steven W.H. Chau, Joey W.Y. Chan, Mandy W.M. Yu, Jessie C.C. Tsang, Shirley Xin Li, Siu Ping Lam, Vincent C.T. Mok, Karen K.Y. Ma, Anne Y.Y. Chan, Jihui Zhang, Yun Kwok Wing   +17 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Cognitive profiles and dementia severity in older patients with atrial fibrillation, with and without ischemic stroke: A cross-sectional study. [PDF]

Sci Prog
Selimbašić Saletović M, Dostović Z, Dostović A, Smajlović D, Ibrahimagić OĆ, Salihović D.   +5 more
europepmc   +1 more source

Imaging Venous Transit Time and Blood–Brain Barrier Permeability of the Deep Brain

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Imaging of venous vessels with advanced pulse sequences allows the assessment of important hemodynamic parameters. Previous work has measured venous transit time (VTT) and blood–brain barrier (BBB) water permeability in cortical tissue.
Wen Shi, Jie Song, Jiani Wu, Yifan Gou, Zhiyi Hu, Vivek Yedavalli, Zixuan Lin, Hanzhang Lu   +7 more
wiley   +1 more source

Late-life difficult-to-treat depression and dementia subtypes: a naturalistic cohort study using electronic health records. [PDF]

Front Psychiatry
Pozuelo Moyano B, Orgeta V, von Gunten A, Vandel P, Ma R, Stewart R, Mueller C.   +6 more
europepmc   +1 more source

Perspectives on ethnic and racial disparities in Alzheimer\u27s disease and related dementias: Update and areas of immediate need [PDF]

, 2019
Babulal, Ganesh M, et al,, Roe, Catherine M   +2 more
core   +1 more source

Ultrafast fMRI Detects Age‐Related Changes in Harmonics of Cardiac Pulsations in the Brain at 7 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Aging impacts pulsatility of blood vessels in the brain, reflecting vascular health. Resolving characteristics of cardiac pulsatility requires faster acquisitions than traditional fMRI. An ultrafast fMRI method was developed and applied to sample several harmonics of cardiac pulsations at 7 T.
Charles Marchini, Dema Abdelkarim, Yuhui Chai, Monica Fabiani, Gabriele Gratton, Bradley P. Sutton   +5 more
wiley   +1 more source

Quantifying Cardiac, Respiratory, and Low Frequency Components of CSF Motion From fMRI Inflow Effects

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Cerebrospinal fluid (CSF) flow oscillations have emerged as a potentially important marker related to brain clearance, but their acquisition often relies on specialized imaging MRI sequences. The purpose of this work was to enable quantitative assessment of CSF flow associated with cardiac, respiratory, and low‐frequency cycles using ...
Pontus Söderström, Cecilia Björnfot, Britt M. Andersson, Jan Malm, Anders Eklund, Anders Wåhlin   +5 more
wiley   +1 more source