Results 161 to 170 of about 1,356,534 (397)
Microvascular Health as a Key Determinant of Organismal Aging
Advanced Science, EarlyView.This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini +4 more
wiley +1 more source
Prevalence of disability according to multimorbidity and disease clustering: a population-based study [PDF]
, 2011 Background: The prevalence of chronic diseases has increased with population ageing, and research has attempted to elucidate the correlation between chronic diseases and disability. However, most studies in older populations have focused on the effect of
Angleman, Sara +2 more
core +1 more source
The temporal onset of the core features in dementia with Lewy bodies
, 2021 Parichita Choudhury +22 more
openalex +2 more sources
Functional mobility decline and incident mild cognitive impairment and early dementia in community-dwelling older adults: the Singapore Longitudinal Ageing Study [PDF]
, 2022 Tze Pin Ng +10 more
openalex +1 more source
Advanced Science, EarlyView.TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu +7 more
wiley +1 more source
Frontiers in Aging NeuroscienceIntroductionPrevious research has tended to focus on early-life education for dementia risk reduction, yet there are great gains for building cognitive reserve in mid- to later-life through educational interventions.
Eddy Roccati +10 more
doaj +1 more source
Increased expression of pathological markers in Parkinson’s disease dementia post-mortem brains compared to dementia with Lewy bodies [PDF]
, 2022 Haitao Tu +10 more
openalex +1 more source
A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E
Advanced Science, EarlyView.This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani +20 more
wiley +1 more source
Paraoxonase 1 Polymorphism p.Q192R in Patients With Dementia [PDF]
, 2011 PON1 PCR-RFLP polymorphism frequency and enzyme activity were determined in 223 patients with dementia (94 with AD, 55 with VaD and 74 with MD) and in 100 age and sex matched controls without dementia.
Tomasz Krzywkowski
core +1 more source