Results 161 to 170 of about 1,330,157 (395)

Dementia prevention, intervention, and care

The Lancet, 2017
G. Livingston, A. Sommerlad, V. Orgeta, S. Costafreda, Jonathan Huntley, D. Ames, C. Ballard, Sube Banerjee, A. Burns, J. Cohen-Mansfield, C. Cooper, Nick Fox, L. Gitlin, R. Howard, H. Kales, E. Larson, K. Ritchie, K. Rockwood, E. Sampson, Quincy M. Samus, L. Schneider, G. Selbæk, L. Teri, N. Mukadam   +23 more
semanticscholar   +1 more source

Paraoxonase 1 Polymorphism p.Q192R in Patients With Dementia [PDF]

, 2011
PON1 PCR-RFLP polymorphism frequency and enzyme activity were determined in 223 patients with dementia (94 with AD, 55 with VaD and 74 with MD) and in 100 age and sex matched controls without dementia.
Tomasz Krzywkowski
core   +1 more source

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

Advanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox, Melanie Burke, Sara Milani, Matthew A White, Fergal M Waldron, Dorothea Böken, Evgeniia Lobanova, Jemeen Sreedharan, Jenna M Gregory, David Klenerman   +9 more
wiley   +1 more source

TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy

Cell Reports
Summary: Dysfunction of the blood-brain barrier (BBB) is recognized as a key factor in the progression of neurodegenerative diseases (NDs), but the detailed mechanisms behind its pathogenesis and impact on neurodegeneration remain elusive.
Min-Tae Jeon, Sinnead Anne Cogill, Kyu-Sung Kim, Yongjin Kim, Hyerin Kim, Chung-Yeol Lee, Suji Kim, Suhyeon Son, Jeongyeon Kim, Jaehyeok Lee, Inyeong Park, Mookyung Cheon, Do-Geun Kim   +12 more
doaj   +1 more source

Case of Grave Lesion of Both Corpora Striata: Recovery from Hemiplegia; Extensive Cerebral Degeneration; Dementia; Death Twelve Days after Rupture of Intrathoracic Aneurism [PDF]

, 1875
W. Julius Mickle
openalex   +1 more source

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, EarlyView.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

A RARE PRESENILE DEMENTIA ASSOCIATED WITH CORTICAL BLINDNESS (HEIDENHAIN'S SYNDROME) [PDF]

, 1954
Adolf Meyer, Denis Leigh, C. E. Bagg
openalex   +1 more source

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

FAMILIAL PRESENILE DEMENTIA: REPORT OF CASE WITH CLINICAL AND PATHOLOGICAL FEATURES OF ALZHEIMER'S DISEASE [PDF]

, 1939
W. H. McMenemey, C. Worster‐Drought, James Flind, Helen Williams   +3 more
openalex   +1 more source

The Prevention of Dementia

European Journal of Cardiovascular Prevention & Rehabilitation, 2001
AbstractObjectiveDementia is prevalent in older adults and the population is ageing. Many factors have been associated with dementia and anything that may aid the prevention of dementia is of importance.MethodThe literature in this area was evaluated and information relating to the various factors that may impact upon the prevention of dementia is ...
openaire   +6 more sources