Results 61 to 70 of about 59,740 (225)

Brainstem atrophy in dementia with Lewy bodies compared with progressive supranuclear palsy and Parkinson’s disease on MRI

BMC Neurology, 2023
Background Although Dementia with Lewy bodies (DLB) is the second most common form of dementia in elderly patients, it remains underdiagnosed compared with Alzheimer's (AD) and Parkinson's diseases (PD).
Sebastian Johannes Müller, Eya Khadhraoui, Niels Hansen, Ala Jamous, Philip Langer, Jens Wiltfang, Christian Heiner Riedel, Caroline Bouter, Christoph van Riesen, Fabian Maass, Michael Bartl, Claudia Lange, Marielle Ernst   +12 more
doaj   +1 more source

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
core   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, EarlyView.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

Renin–angiotensin system gene polymorphisms among Saudi patients with coronary artery disease [PDF]

, 2014
BACKGROUND: Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated ...
Della Rosa, Eidelberg, Frauscher, Gagnon, Holtbernd, Holtbernd, Huang, Hughes, Hummel, Iranzo, Iranzo, Iranzo, Iranzo, Ma, Mahlknecht, McKeith, Meles, Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease, Niethammer, Ponsen, Postuma, Postuma, Schenck, Schenck, Spetsieris, Stiasny-Kolster, Stiasny-Kolster, Stoffers, Tang, Teune, Tripathi, Wu, Zande   +32 more
core   +4 more sources

Association between Plasma P‐tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Clinically relevant Alzheimer's disease co‐pathology is common in Lewy body disorders. Plasma P‐tau217 is a sensitive biomarker for amyloid and tau pathology in Alzheimer's disease. The objective was to determine if plasma P‐tau217 associates with Alzheimer's disease co‐pathology and cognition in Lewy body disorders. Methods Participants had (
Thomas F. Tropea, Patricia Aldea Stevenson, Matthew Flitter, David Meehan, Amanda Morris, Ming Lu, Leonardo Iaccarino, Emily C. Collins, Michael E. Hodsdon, David Irwin, Meredith Spindler, Andres Deik, Nabila Dahodwala, Katheryn A.Q. Cousins, David A. Wolk, Leslie Shaw, Daniel Weintraub, Edward B. Lee, Alice Chen‐Plotkin, Mark Mintun, Andrew Siderowf   +20 more
wiley   +1 more source

Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease

Dementia and Geriatric Cognitive Disorders Extra, 2019
Introduction: The aim of the study is to describe the frequency of frailty in people with a new diagnosis of mild dementia due to Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Methods: This is a secondary analysis of the Dementia Study of
Miguel Germán Borda, Hogne Soennesyn, Claire J. Steves, Audun Osland Vik-Mo, Mario Ulises Pérez-Zepeda, Dag Aarsland   +5 more
doaj   +1 more source

Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: Marker candidates for dementia with Lewy bodies [PDF]

, 2007
Background: The measurement of biomarkers in cerebrospinal fluid (CSF) has gained increasing acceptance in establishing the diagnosis of some neurodegenerative diseases.
Andreasen N, Brit Mollenhauer, Claudia Trenkwalder, Erik Bahn, Fahn S, Goetz CG, Hans A. Kretzschmar, Hoehn MM, Hughes AJ, Hulstaert F, Jens Wiltfang, Joseph J. Locascio, Knopman DS, Markus Otto, McKeith IG, McKhann G, Metz CE, Michael G. Schlossmacher, Mirko Bibl, Mollenhauer B, Oide T, Peter Brechlin, Petra Steinacker, Schlossmacher MG, Sigrid Poser, Takeuchi Y, Wiltfang J, Wodzig KW   +27 more
core   +1 more source

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

Research on the perspectives of people affected by dementia with Lewy bodies: a scoping review

Alzheimer’s Research & Therapy
Background Dementia with Lewy bodies (DLB) is associated with specific challenges, including heterogeneity in clinical presentation and a less favourable prognosis relative to other dementia subtypes.
Paula Sinead Donnelly, Aoife Sweeney, Anthony P. Passmore, Noleen K. McCorry, Joseph P. M. Kane   +4 more
doaj   +1 more source

Dementia with Lewy bodies – a clinicopathological update

Free Neuropathology, 2020
Dementia is one of the major burdens of our aging society. According to certain predictions, the number of patients will double every 20 years. Although Alzheimer’s disease (AD), as the most frequent neurodegenerative dementia, has been extensively ...
János Bencze, Woosung Seo, Abdul Hye, Dag Aarsland, Tibor Hortobágyi   +4 more
doaj   +1 more source