Results 131 to 140 of about 47,850 (262)

m6A‐Mediated Stabilization of MRPS23 Drives NSCLC Progression Via HSPA8 and ERK Signaling Modulation

Cancer Science, EarlyView.
MRPS23 mRNA is m6A‐methylated by WTAP and stabilized by IGF2BP3, leading to increased MRPS23 protein. MRPS23 physically interacts with HSPA8, and this interaction is functionally associated with activation of the RAS–RAF–MEK–ERK pathway, ultimately promoting NSCLC cell proliferation and tumor progression.
Sihong Le, Yitao Le, Xianshen Sha, Feng Qiu, Ling Zhang   +4 more
wiley   +1 more source

Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency. [PDF]

Sci Adv
Pérez-Sisqués L, Bhatt SU, Caruso A, Robb JL, Donovan APA, Bamford R, Torres-Cano A, Spring S, Hendy E, Gileadi TE, Panasiuk M, Trengove J, Jindal N, Ahmed MU, Sabbioni M, Taylor-Papadimitriou J, Cash D, Clifton N, Ellegood J, Andreae LC, Lerch JP, Scattoni ML, Giese KP, Fernandes C, Basson MA.   +24 more
europepmc   +1 more source

Manuka Honey Sinus Irrigation Versus Systemic Itraconazole in Allergic Fungal Rhinosinusitis: Randomised Clinical Trial for Efficacy and Safety

Clinical Otolaryngology, EarlyView.
ABSTRACT Background Allergic fungal rhinosinusitis (AFRS) is a persistent sinus condition caused by fungal allergies. Endoscopic sinus surgery (ESS) and postoperative systematic and local medical therapies are the most common treatment protocols. Although oral antifungals such as itraconazole are frequently utilised postoperatively, there is increasing
Khalaf Hamead, Mostafa Ismail, Abdelrahim A. Abdelkarim, Abdelhakim Atef Abdelhakim, Khaled Mohamed Abdelzaher   +4 more
wiley   +1 more source

Erratum: Histone demethylase KDM4C activates HIF1α/VEGFA signaling through the costimulatory factor STAT3 in NSCLC. [PDF]

Am J Cancer Res
Wu X, Deng Y, Zu Y, Yin J.
europepmc   +1 more source

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

FgJhd2 Modulates FgMpf2 Expression via H3K4 Demethylation and Influences Sexual Development in Fusarium graminearum. [PDF]

Environ Microbiol
Liao X, Yao L, Wang J, Chen Y, Chen S, Qi Z, Chen Y.   +6 more
europepmc   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Quadratic Concentration-Response Modeling and Molecular Docking of <i>Mespilodaphne quixos</i> (Lam.) Rohwer Essential Oil Against <i>Candida albicans</i>. [PDF]

Molecules
Arteaga-Crespo Y, García-Quintana Y, Velásquez López Y, Radice M, Conforme-Garcia MM, Rivera-Barreto JL, Blanco-Salas J, Abreu-Naranjo R.   +7 more
europepmc   +1 more source

Fungicide Non‐Target Effects Cause Reduced Sawfly Herbivory in Treated and Neighbouring Strawberry Plants

Entomologia Experimentalis et Applicata, EarlyView.
Application of the fungicide Switch 62.5 WG in garden strawberry (Fragaria × ananassa), targeting Botrytis cinerea, reduced sawfly (Cladius spp.) herbivory by up to 94% and improved fruit quality. This non‐target effect also spilled over to neighbouring untreated plants, lowering damage by 46%.
Esther Kuper, Mudassir Iqbal, Åsa Lankinen, Erik Andreasson, Johan A. Stenberg   +4 more
wiley   +1 more source

KDM5A methylation modulates its genomic demethylase and transcriptional actions. [PDF]

J Biol Chem
Tran TA, Gopinathan G, Nuñez CG, Goodavish F, Wu SY, Tran R, Lemoff A, Girard L, Martinez ED.   +8 more
europepmc   +1 more source