Results 251 to 260 of about 98,772 (389)

Comprehensive Quantification of Oligoasthenozoospermia Induced by Obesity, Reproductive Toxicants, and Their Combination in Rat Models

Andrology, EarlyView.
ABSTRACT Background Oligoasthenozoospermia is a leading cause of male infertility and has been increasingly associated with the global surge in obesity and exposure to reproductive toxicants. Despite extensive research on each factor individually, their combined pathological effects remain poorly understood.
Yunlong Yao, Xi Zhang, Lingru Li, Yunzhi Zhang, Shuo Huang, Yulin Zong, Mingrui Li, Fufangyu Zhao, Linghui Zhu, Tianxing Li, Wenlong Sun, Mingyan Shao, Yanfei Zheng   +12 more
wiley   +1 more source

KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma. [PDF]

Cancer Res
Figuerola-Bou E, Ríos-Astorch C, Blanco E, Sánchez-Jiménez M, Táboas P, Fernández G, Gómez-González S, Muñoz O, Castellano-Escuder P, Perez-Jaume S, Garcia M, Prada E, Mateo-Lozano S, Riggi N, Avgustinova A, Lavarino C, Di Croce L, Sánchez-Molina S, Mora J.   +18 more
europepmc   +1 more source

Selective small molecule targeting of KDM4 as a therapeutic strategy to reduce proliferation of acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is an aggressive disease with poor survival and high relapse rates. Coupled with the complex mutational burden observed, there is an unmet clinical need for more targeted therapies. Epigenetic therapies have shown promise both as monotherapy and in combination strategies and specifically histone lysine demethylase,
Laura Monaghan, Roderick P. Bunschoten, Joana Bittencourt‐Silvestre, Taeju Park, Susan Gannon, Petrisor Alin Pirvan, Alex Hoose, Helen Wheadon, Robert M. J. Liskamp, Xu Huang, Heather G. Jørgensen   +10 more
wiley   +1 more source

FTO-Eci1 Axis Mediates Exercise-Induced Cardioprotection in Pressure Overload Mice. [PDF]

Biomolecules
Wang J, Chang Z, Lin S, Sha G, Zeng W, Huang Q, Deng Q, Wang S, Hu M, Xia J.   +9 more
europepmc   +1 more source

Extracellular matrix detached cancer cells resist oxidative stress by increasing histone demethylase KDM6 activity

, 2023
Mohamed A. Alfaleh, Mohammed Razeeth Shait Mohammed, Anwar M. Hashem, Turki S. Abujamel, Nabil A. Alhakamy, Mohammad Imran Khan   +5 more
openalex   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Losing is the new winning: loss of histone demethylase DT2 enhances drought stress tolerance in rice. [PDF]

Plant Physiol
Sharma G.
europepmc   +1 more source

The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species

Science, 2018
C. Ge, Jian Ye, C. Weber, Wei Sun, Haiyan Zhang, Yingjie Zhou, C. Cai, Guoying Qian, B. Capel   +8 more
semanticscholar   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

KDM3A drives NSCLC proliferation and metastasis via H3K9 demethylation, EMT activation and MMP-9 upregulation. [PDF]

Biomol Biomed
Shi B, Wang Z, Xiu L, Li L, Yang X, Wang G, Li J, Wang H, Han Y.   +8 more
europepmc   +1 more source