Results 251 to 260 of about 95,899 (339)

KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification. [PDF]

open access: yesCell Death Discov
Liu F   +16 more
europepmc   +1 more source

Cell‐Type‐Specific WTAP and ALKBH5‐Mediated m6A Methylation Orchestrates Mental Disorders via Gut‐Brain Axis Metabolite Signaling: Multi‐Omics Evidence and Pyroptosis‐Associated Loop Mechanism

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
MR analysis revealed distinct causal associations of m6A modifiers (WTAP/ALKBH5) with mental disorders. Gut microbiota (GCA‐900066755, Bacillus) and CSF metabolites (theophylline, isoleucine) mediated 5.06%–45.28% of effects via pathways such as WTAP → GCA‐900066755 → theophylline → ADHD. Single‐cell eQTL linked WTAP‐mediated ADHD risk to XCL1‐NK cells,
Jingjing Zhang   +4 more
wiley   +1 more source

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation

open access: yesClinical and Translational Medicine, Volume 16, Issue 3, March 2026.
ALKBH3 alleviates myocardial ischemia/reperfusion injury by suppressing PANoptosis. ALKBH3 promotes ZBED6 translation via mRNA m1A demethylation. ZBED6 promotes the interaction between STAT1 and NEDD4L to facilitate STAT1 ubiquitination and subsequent degradation.
Hongtao Diao   +14 more
wiley   +1 more source

Study on the Potential Molecular Mechanisms of Sodium Dehydroacetate (Na‐DHA) Interfering With Bone Metabolism and Inducing Osteoporosis Based on Network Toxicology, Molecular Docking, and In Vitro Experimental Validation

open access: yesFood Science &Nutrition, Volume 14, Issue 3, March 2026.
The main workflow and core design concept of the current study. ABSTRACT Sodium Dehydroacetate (Na‐DHA), a widely used food additive, has raised concerns about the chronic health risks associated with long‐term exposure. However, the potential impact of Na‐DHA on bone metabolism, its contribution to osteoporosis risk, and the specific molecular ...
Weihong Qian   +6 more
wiley   +1 more source

Sargassum incisifolium and Ulva spp metabolites activity and their molecular dynamics simulation against Fusarium oxysporum 14-alpha-demethylase. [PDF]

open access: yesBiotechnol Rep (Amst)
Aina O   +10 more
europepmc   +1 more source

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