Results 301 to 310 of about 95,899 (339)

m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program

Cancer Cell, 2017
Sicong Zhang, Boxuan Simen Zhao, Aidong Zhou   +2 more
exaly   +2 more sources

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Cancer Cell, 2019
FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two promising FTO inhibitors, namely FB23 and FB23-2, which directly bind to FTO and selectively inhibit ...
Yue Huang, Rui Su, Lei Dong
exaly   +2 more sources

Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis

Nature Communications, 2021
Here we show that FTO as an N6-methyladenosine (m6A) RNA demethylase is degraded by selective autophagy, which is impaired by low-level arsenic exposure to promote tumorigenesis. We found that in arsenic-associated human skin lesions, FTO is upregulated,
Yan-Hong Cui, Seungwon Yang, Jiangbo Wei
exaly   +2 more sources

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Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation

Journal of the American Chemical Society, 2021
The epigenetic modification of nucleic acids represents a versatile approach for achieving high-efficient control over gene expression and transcription and could dramatically expand their biosensing and therapeutic applications.
Qing Wang, Xiaoqing Liu, Xiaocheng Weng
exaly   +2 more sources

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

Nature Communications, 2020
Autophagy is essential for cellular survival and energy homeostasis under nutrient deprivation. Despite the emerging importance of nuclear events in autophagy regulation, epigenetic control of autophagy gene transcription remains unclear. Here, we report
Young-Chae Kim, Yang Zhang, Peter M Yau
exaly   +2 more sources

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3

Molecular Cancer, 2019
N6-methyladenosine (m6A) modification is the most pervasive modification in mRNA, and has been considered as a new layer of epigenetic regulation on mRNA processing, stability and translation.
Honglei Chen, Yuan Wang, Bo Wei
exaly   +2 more sources

An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis

Cell Research, 2019
Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing ...
Qun Li, Muyang Wang, Yiwen Deng
exaly   +2 more sources

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

Nucleic Acids Research, 2017
N6-methyladenosine (m6A) is the most abundant base modification found in messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase established the concept of reversible RNA modification. Here, we present a comprehensive transcriptome-
Marek Bartosovic, Grzegorz Kudła, Stepanka Vanacova   +2 more
exaly   +2 more sources

When Is a Demethylase Not a Demethylase?

Science, 2011
The histone lysine demethylase JARID1a has demethylase-independent function in the circadian clock.
openaire   +2 more sources

Inhibitors of histone demethylases

Bioorganic & Medicinal Chemistry, 2011
Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.
Lohse, Brian, Kristensen, Jesper L, Kristensen, Line H, Agger, Karl, Helin, Kristian, Gajhede, Michael, Clausen, Rasmus P   +6 more
openaire   +3 more sources