Results 271 to 280 of about 97,922 (342)

Cytotoxic Lesions of the Corpus Callosum Preceding Osmotic Demyelination Syndrome in Hypernatremia and Hyperosmolar Hyperglycemic State: A Case Report. [PDF]

Electrolyte Blood Press
Park HJ, Song SH, Suh SH, Choi HS, Bae EH, Ma SK, Kim SW, Kim CS.   +7 more
europepmc   +1 more source

Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions

MedComm, Volume 6, Issue 9, September 2025.
Heavy metals exert a wide range of effects at the cellular, molecular, and genetic levels, leading to neurological damage, renal dysfunction, cardiovascular disease, reproductive developmental abnormality, immune system abnormality, and increased risk of cancer by interfering with biomolecule function, signaling pathways, inducing oxidative stress, and
Yu‐feng Cheng, Yu‐jia Zhao, Ce Chen, Feng Zhang   +3 more
wiley   +1 more source

Validation of a data-driven multicomponent T2 analysis for quantifying myelin content in the cuprizone mouse model of multiple sclerosis. [PDF]

PLoS One
Omer N, Wilczynski E, Zlotzover S, Helft C, Blumenfeld-Katzir T, Ben-Eliezer N.   +5 more
europepmc   +1 more source

Spatiotemporal Dynamics of Central Nervous System Diseases: Advancing Translational Neuropathology via Single‐Cell and Spatial Multiomics

MedComm, Volume 6, Issue 9, September 2025.
Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia, Quan Liu, Wenli Zhang, Jinwen Ge, Zhigang Mei   +4 more
wiley   +1 more source

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source

Low-Intensity Physical Exercise is Associated with Improved Myelination and Reduced Microglial Activation in a Cuprizone-Induced Demyelination Model. [PDF]

Neurochem Res
Hahn KR, Hwang IK, Yoo DY.
europepmc   +1 more source

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches

Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Morteza Rajabi, Sajjad Shafaeibajestan, Sevda Asadpour, Ghazal Alyari, Niloofar Taei, Moein Kohkalani, Ramin Raoufinia, Hamed Afarande, Ehsan Saburi   +8 more
wiley   +1 more source

Paraneoplastic Tumefactive Demyelination With Underlying Anaplastic Thyroid Cancer: A Case Report and Review of the Literature. [PDF]

J Cent Nerv Syst Dis
Panagiotis CI, Hakim A, Lidia S, Christine SN, Attila K, Andrew C, Sophie B, Anke S, Robert H, Hammer H.   +9 more
europepmc   +1 more source

Effects of Phenobarbital and Prednisolone on Neurological Signs of Canine Distemper

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
This study investigates the effects of phenobarbital and prednisolone on neurological signs of canine distemper (CD) in 35 dogs. Among 25 dogs testing positive for canine distemper virus (CDV), treatment outcomes showed limited recovery with prednisolone (8% recovery rate) and effective seizure control with phenobarbital.
Ali Asghar Sarchahi, Mohammad Arbabi, Hadi Mohebalian   +2 more
wiley   +1 more source

Laser-Induced Cortical Lesions in Mice as a Model for Progressive Multiple Sclerosis Pathology. [PDF]

Biomedicines
Ojha B, Ramazani B, Belal R, Krieger J, Bloksgaard M, Lyszczarz GT, Rusin D, Wlodarczyk A, FitzGerald U, Owens T, Khorooshi R.   +10 more
europepmc   +1 more source