Results 21 to 30 of about 85,577 (346)

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy.

Journal of the American Chemical Society, 2018
Small interfering RNA (siRNA) is emerging as a novel therapeutic for treating various diseases, provided a safe and efficient delivery is available. In particular, specific delivery to target cells is critical for achieving high therapeutic efficacy ...
Yiwen Dong, Tianzhu Yu, Ling Ding, E. Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peizhuo Chen, D. Marson, Yifan Jiang, S. Giorgio, S. Pricl, Xiaoxuan Liu, P. Rocchi, Ling Peng   +15 more
semanticscholar   +1 more source

Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses. [PDF]

PLoS Computational Biology, 2011
The crystal structure of the TLR4-MD-2-LPS complex responsible for triggering powerful pro-inflammatory cytokine responses has recently become available. Central to cell surface complex formation is binding of lipopolysaccharide (LPS) to soluble MD-2. We
Teresa S Barata, Ian Teo, Steve Brocchini, Mire Zloh, Sunil Shaunak   +4 more
doaj   +1 more source

Binary tree-inspired digital dendrimer

Nature Communications, 2019
Digital polymers with precisely ordered units acting as the coded 0- or 1-bit, are introduced as a promising option for molecular data storage. However, the pursuit of better performance in terms of high storage capacity and useful functions never stops.
Zhihao Huang, Qiunan Shi, Jiang Guo, Fanying Meng, Yajie Zhang, Yutong Lu, Zhuangfei Qian, Xiaopeng Li, Nianchen Zhou, Zhengbiao Zhang, Xiu-lin Zhu   +10 more
semanticscholar   +1 more source

Coherent exciton transport in dendrimers and continuous-time quantum walks [PDF]

, 2006
We model coherent exciton transport in dendrimers by continuous-time quantum walks (CTQWs). For dendrimers up to the second generation the coherent transport shows perfect recurrences, when the initial excitation starts at the central node.
Bierbaum, Veronika, Blumen, Alexander, Muelken, Oliver   +2 more
core   +1 more source

Curcumin encapsulation using dendrimer PAMAM G4 conjugated with polyethylene glycol to improve the properties of gel dossage form [PDF]

Pharmaciana, 2018
Curcumin had a low bioavailability, to improve it than curcumin was encapsulated in the PAMAM dendrimer conjugated PEG. To facilitate topical use, curcumin dendrimer was combined with a carbomer 940 that can produce hydration conditions in the stratum ...
Rahmah Elfiyani , Yudi Srifiana, Faisal Dharojat Al Rasyied   +2 more
doaj   +1 more source

Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics

Theranostics, 2018
Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to translate into clinical success due to their nonspecific cellular ...
Anjali Sharma, K. Liaw, Rishi Sharma, Zhi Zhang, S. Kannan, R. Kannan   +5 more
semanticscholar   +1 more source

Amine functionalization of cholecyst-derived extracellular matrix with generation 1 PAMAM dendrimer [PDF]

, 2008
This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Biomacromolecules, copyright © American Chemical Society after peer review.
Angele P., Babensee J. E., Badylak S., Badylak S. F., Badylak S. F., Badylak S. F., Billiar K., Brody S., Burugapalli K., Buttafoco L., Chandrasekar D., Charulatha V., Chen R. R., Coburn J. C., Curotto E., Domanski D. M., Duan X., Duan X., Duan X., DuBay D. A., Dumas P., Ferrando J. M., Garcia Y., Grinnell F., Henry J. A., Hodde J., Hodde J. P., Ko R., Kochupura P. V., Koizumi N. J., Lee J. M., Lee S. H., Liang H. C., Ma L., Ma Z., Malafaya P. B., McDevitt C. A., McKegney M., Meinert M., Najlah M., Nourse A., Olde Damink L. H., Olde Damink L. H., Osborne C. S., Papagiannaros A., Pek Y. S., Pieper J. S., Saito H., Sokolsky-Papkov M., Tabata Y., Tessmar J. K., Unsworth J. M., van Wachem P. B., van Wachem P. B., van Wachem P. B., Voytik-Harbin S. L., Wissink M. J., Wissink M. J., Wolkers W. F., Yee N., Zhong S., Zilla P.   +61 more
core   +1 more source

Turn-on Type Chemical Sensing of Vitamin K4 by Fluorene Dendrimers with Naphthalene Segments

Molecules, 2014
G1 and G2 fluorene dendrimers with naphthalene termini were synthesized as a fluorescence turn-on type chemical sensor for vitamin K4. The fluorene dendrimers were prepared by Williamson ether reaction between the fluorene core with dihydroxy groups and ...
Naoya Adachi, Hiroki Sugiyama, Masafumi Arai, Hideo Ogawa   +3 more
doaj   +1 more source

Investigations of excitation energy transfer and intramolecular interactions in a nitrogen corded distrylbenzene dendrimer system. [PDF]

, 2002
The photophysics of an amino-styrylbenzene dendrimer (A-DSB) system is probed by time-resolved and steady state luminescence spectroscopy. For two different generations of this dendrimer, steady state absorption, emission, and photoluminescence ...
Becky Letchford, Clare Mackie, Conti-Ramsden, G., Coopersmith, S., Coopersmith, S., Dockrell, J., Dockrell, J., Geoff Lindsay, Harter, S., Harter, S., Harter, S., Julie Dockrell, McGuire, S., Piers, E. V., Wylie, R. C., Wylie, R. C.   +15 more
core   +4 more sources

Original Multivalent Gold (III) and Dual Gold(III)-Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents [PDF]

, 2017
Original metallophosphorus dendrimers (generation 3, 48 terminal groups) have been prepared via the complexation of phosphorus dendrimers bearing imino-pyridino end groups with Au(III) or with both Au(III) and Cu(II).
Serge M. Mignani, Nabil El Brahmi, Saïd El Kazzouli, Regis Laurent, Sonia Ladeira, Anne-Marie Caminade, Elzbieta Pedziwiatr-Werbicka, Eligia M. Szewcyk, Maria Bryszewska, Mosto M. Bousmina, Thierry Cresteil, Jean Pierre Majoral   +11 more
core   +2 more sources