Results 121 to 130 of about 31,221 (269)

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

Periodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Rational design of novel, fluorescent, tagged glutamic acid dendrimers with different terminal groups and in silico analysis of their properties

, 2017
Nuno Martinho,1–3 Liana C Silva,1,4 Helena F Florindo,1 Steve Brocchini,2 Mire Zloh,3 Teresa S Barata2 1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal; 2Department of Pharmaceutics ...
Silva LC, Zloh M, Barata TS, Martinho N, Brocchini S, Florindo HF   +5 more
core  

Chemical‐Assembled Macrophage‐Engaging Glypican‐3 × Signal Regulatory Protein‐α (SIRP‐α) Bispecific Antibody for Immunotherapy Against Liver Cancer

MedComm, Volume 7, Issue 7, July 2026.
We developed a novel chemical strategy to generate a glypican‐3 × SIRP‐α bispecific antibody that simultaneously blocks the CD47 “don't eat me” signal, engages macrophages to target liver cancer cells for enhanced phagocytosis, and antigen presentation. This novel combination of targets demonstrates remarkable efficacy in vitro and in vivo.
Bo Tang, Wing Hei Leung, Chihao Shao, Dongfang Li, Kwai Man Lau, Macro K. H. Lui, Jingyi Liu, Jacky C. H. Chu, Clare S. W. Yan, Chi‐Ming Che, Xuechen Li, Wing‐Tak Wong, Larry Ming Cheung Chow, Terence K. W. Lee, Clarence T. T. Wong   +14 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Tuning catalytic activity and sensitivity in urease‐based thin film biosensors using conjugated polymers and eugenol/biseugenol

Polymer International, Volume 75, Issue 7, Page 609-617, July 2026.
Hybrid thin films of conjugated polymers and urease modified with eugenol derivatives show that polymer–biomolecule interactions enhance catalytic activity while distinctly modulating electrolyte–insulator–semiconductor sensor sensitivity. Abstract Thin films have emerged as promising platforms for biosensor development due to their versatility and ...
Thaísa da Silva de Souza, Cléber Gomes de Jesus, Paulo Vitor de Morais, José Roberto Siqueira Junior, Michael Josef Schöning, João Henrique Ghilardi Lago, Luciano Caseli, Laura Oliveira Péres   +7 more
wiley   +1 more source

Peptide dendrimers as “lead compounds” for the treatment of chronic lung infections by Pseudomonas aeruginosa in cystic fibrosis patients: in vitro and in vivo studies

, 2018
Arianna Pompilio,1,2 Cristina Geminiani,1,2 Paolo Mantini,1,2 Thissa N Siriwardena,3 Ivan Di Bonaventura,3 Jean Louis Reymond,3 Giovanni Di Bonaventura1,2 1Department of Medical, Oral, and Biotechnological Sciences, G d’Annunzio University of ...
Geminiani C, Siriwardena TN, Pompilio A, Reymond JL, Mantini P, Di Bonaventura I, Di Bonaventura G   +6 more
core  

Autocatalytic Deprotection of Diboronate‐Protected Quinones via Redox Cross‐Catalysis: Mechanistic Insights Into Double Masking Strategies

ChemSystemsChem, Volume 8, Issue 4, July 2026.
Mechanistic insights and design principles of diprotected molecular probes for autocatalytic redox amplification systems: assessing the influence of molecular structure symmetry and electronic substituent effects on the double deprotection and autocatalytic response. ABSTRACT We report an autocatalytic molecular amplification system based on the double
Pan Hui, Alexandra Pastor, Mathieu Branca, Benoît Limoges, François Mavré   +4 more
wiley   +1 more source

Bacterial Ghosts as Innovative Transport Vehicles for Platinum‐Based Anticancer Drugs

ChemMedChem, Volume 21, Issue 12, 26 June 2026.
Bacterial ghosts (BGs), empty envelopes of Gram‐negative E. coli, are introduced as versatile carriers for platinum anticancer drugs. Oxaliplatin (OXA) shows high loading, stability, and reproducible encapsulation, while retaining full cytotoxicity in vitro.
Irena Pashkunova‐Martic, Matthias H. M. Klose, Pavol Kudela, Diana Groza‐Weber, Siegfried Reipert, Christian R. Kowol, Petra Heffeter, Walter Berger, Bernhard K. Keppler, Werner Lubitz   +9 more
wiley   +1 more source

Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A

, 2011
We described herein the synthesis of second generation glycopeptide dendrimers G2a-g presenting variable amino acids placed internally into the multivalent scaffold. The effect of such structural modulation on recognition processes by Concanavalin A (Con
Reymond, Jean-Louis, Jean-Louis Reymond, Euzen, Ronan, Ronan Euzen   +3 more
core   +1 more source

Redox‐Active Guanidines

ChemElectroChem, Volume 13, Issue 12, 17 June 2026.
Redox‐active guanidines, comprising guanidino‐functionalized aromatics (GFAs) and redox‐active urea azines (RAAs), are electron donors and strong Lewis and Brønsted bases that are used in several applications. They act as redox‐active ligands in bistable coordination compounds and as reagents in dehydrogenative coupling reactions and proton‐coupled ...
Hans‐Jörg Himmel
wiley   +1 more source