Results 1 to 10 of about 29,333 (179)
Acetylation of PAMAM dendrimers for cellular delivery of siRNA [PDF]
BMC Biotechnology, 2009 AbstractBackgroundThe advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery process.
Waite, Carolyn L +3 more
openaire +6 more sources
PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy
Applied Materials Today, 2018 Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have indiscriminate cytotoxicity that affects normal, as well as cancer cells.
Fereydoon Abedi-Gaballu +2 more
exaly +2 more sources
Journal of Materials Research and Technology, 2020 Nickel is a toxic metal and present in the effluents of electroplating industries. Conventional methods to remove nickel are expensive and ineffective. Heavy metals can be easily adsorbed by dendrimers.
Isra Sohail +8 more
doaj +2 more sources
Nanomaterials, 2017 One of the most studied nanocarriers for drug delivery are polyamidoamine (PAMAM) dendrimers. However, the alterations produced by PAMAM dendrimers in neuronal function have not been thoroughly investigated, and important aspects such as effects on ...
Felipe Vidal +8 more
doaj +2 more sources
From Structure to Function: The Promise of PAMAM Dendrimers in Biomedical Applications
PharmaceuticsPAMAM dendrimers are distinguished by their capacity for functionalization, which enhances the properties of the compounds they transport, rendering them highly versatile nanoparticles with extensive applications in the biomedical domain, including drug,
Said Alamos-Musre +9 more
doaj +2 more sources
Conjugation of Gentamicin to Polyamidoamine Dendrimers Improved Anti-bacterial Properties against Pseudomonas aeruginosa [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: This study aimed to design gentamicin-conjugated poly (amidoamine) (PAMAM) dendrimers to increase the therapeutic efficiency of gentamicin against Pseudomonas aeruginosa.
Hamed Sheykhloo +4 more
doaj +1 more source
Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy
International Journal of Molecular Sciences, 2021 Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers are already successfully used in experimental gene therapies, but despite advantages such as their high transfection efficiency and the wide knowledge of ...
Piotr Tarach, A. Janaszewska
semanticscholar +1 more source
Advanced Drug Delivery Reviews, 2021 Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level.
Hadeel Kheraldine +5 more
semanticscholar +1 more source
Acta Biomaterialia, 2021 The effective life-time of new antimicrobials until the appearance of the first resistant strains is steadily decreasing, which discourages incentives for commercialization required for clinical translation and application.
Guimei Jiang +7 more
semanticscholar +1 more source
Journal of Controlled Release, 2021 Glioblastoma is among the most aggressive forms of cancers, with a median survival of just 15-20 months for patients despite maximum clinical intervention.
Rishi Sharma +8 more
semanticscholar +1 more source