From Structure to Function: The Promise of PAMAM Dendrimers in Biomedical Applications [PDF]
PharmaceuticsPAMAM dendrimers are distinguished by their capacity for functionalization, which enhances the properties of the compounds they transport, rendering them highly versatile nanoparticles with extensive applications in the biomedical domain, including drug,
Said Alamos-Musre +9 more
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Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy. [PDF]
Int J Mol Sci, 2021 Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers are already successfully used in experimental gene therapies, but despite advantages such as their high transfection efficiency and the wide knowledge of ...
Tarach P, Janaszewska A.
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Selective Cellular Uptake and Druggability Efficacy through Functionalized Chitosan-Conjugated Polyamidoamine (PAMAM) Dendrimers [PDF]
SensorsNanotechnology has ushered in significant advancements in drug design, revolutionizing the prevention, diagnosis, and treatment of various diseases. The strategic utilization of nanotechnology to enhance drug loading, delivery, and release has garnered ...
Ye Hu, Jian Chen, Wenyan Hu
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Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells. [PDF]
Colloids Surf B Biointerfaces, 2020 Co-delivery of therapeutic agents and small interfering RNA (siRNA) can be achieved by a suitable nanovehicle. In this work, the solubility and bioavailability of curcumin (Cur) were enhanced by entrapment in a polyamidoamine (PAMAM) dendrimer, and a ...
Ghaffari M +7 more
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New Advances in General Biomedical Applications of PAMAM Dendrimers. [PDF]
Molecules, 2018 Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by Donald A. Tomalia, as a new class of polymers, named ‘starburst polymers’.
Araújo RV +3 more
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PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy. [PDF]
Appl Mater Today, 2018 Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have indiscriminate cytotoxicity that affects normal, as well as cancer cells.
Abedi-Gaballu F +7 more
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Curcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats [PDF]
Frontiers in Cell and Developmental BiologyIntroductionIschemic stroke is a devastating neurovascular condition that occurs when cerebral tissue fails to receive an adequate supply of oxygen. Despite being a leading cause of death and disability worldwide, therapeutic interventions are currently ...
Justin Stadler +25 more
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Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment? [PDF]
Pharmaceutics, 2023 Based on their drug delivery properties and activity against tumors, we combined PAMAM dendrimers with various platinum(IV) complexes in order to provide an improved approach of anticancer treatment.
Yvonne Lerchbammer-Kreith +6 more
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Journal of Materials Research and Technology, 2020 Nickel is a toxic metal and present in the effluents of electroplating industries. Conventional methods to remove nickel are expensive and ineffective. Heavy metals can be easily adsorbed by dendrimers.
Isra Sohail +8 more
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An Available Strategy for Nasal Brain Transport of Nanocomposite Based on PAMAM Dendrimers via In Situ Gel. [PDF]
Nanomaterials (Basel), 2019 Polyamidoamine (PAMAM) dendrimers are efficient drug carriers. The presence of a physiological pathway for nasal brain transport provides a potential path for direct brain-targeted delivery of dendrimer nanocomposites. In this study, we synthesized PAMAM
Xie H +9 more
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