Results 21 to 30 of about 36,882 (246)

Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells [PDF]

Colloids Surf B Biointerfaces, 2019
Co-delivery of therapeutic agents and small interfering RNA (siRNA) can be achieved by a suitable nanovehicle. In this work, the solubility and bioavailability of curcumin (Cur) were enhanced by entrapment in a polyamidoamine (PAMAM) dendrimer, and a ...
M. Ghaffari, G. Dehghan, B. Baradaran, A. Zarebkohan, B. Mansoori, Jafar Soleymani, Jafar Ezzati Nazhad Dolatabadi, Michael R Hamblin   +7 more
semanticscholar   +2 more sources

Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish

International Journal of Nanomedicine, 2014
Joseph B Pryor,1 Bryan J Harper,1 Stacey L Harper1,21Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; 2School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR,
Pryor JB, Harper BJ, Harper SL
doaj   +1 more source

Engineering PAMAM dendrimers for optimized drug delivery

Nano Trends
Dendrimers, first introduced by Fritz Vögtle in 1978, have emerged as promising nanocarriers for drug delivery due to their unique branched architecture, large internal cavities, and numerous surface amine groups.
Amin Aleebrahim Dehkordi, Shirin Mollazadeh, Amirreza Talaie, Mostafa Yazdimamaghani   +3 more
doaj   +3 more sources

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. [PDF]

International Journal of Antimicrobial Agents, 2019
The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characterising ...
A. Holmes, J. Heylings, Ka-Wai Wan, G. Moss   +3 more
semanticscholar   +2 more sources

Cationic PAMAM Dendrimers Disrupt Key Platelet Functions

, 2016
Poly­(amidoamine) (PAMAM) dendrimers have been proposed for a variety of biomedical applications and are increasingly studied as model nanomaterials for such use. The dendritic structure features both modular synthetic control of molecular size and shape
Robert A. Campbell (197299), David W. Grainger (714086), Clinton F. Jones (2078227), S. Fazal Mohammad (2078230), Andrew S. Weyrich (197324), Adriana Vieira-de-Abreu (664432), Zechariah Franks (197305), Benjamin D. Brooks (714084), Dean Y. Li (46432), Christopher C. Gibson (813793), Hamidreza Ghandehari (1329966), Giridhar Thiagarajan (1930012), Sivaprasad Sukavaneshvar (2078233)   +12 more
core   +6 more sources

The Current State of the Art in PAMAM and PLL Dendrimers, Boron Clusters, and Their Complexes for Biomedical Use [PDF]

Biomedicines
Poly(amidoamine) (PAMAM) and poly-L-lysine (PLL) dendrimers have emerged as highly versatile macromolecular platforms with significant potential in biomedical applications, owing to their well-defined architecture, tunable surface chemistry, and capacity
Agnieszka Maria Kołodziejczyk, Edyta Błaszczyk, Bolesław T. Karwowski   +2 more
doaj   +2 more sources

PAMAM dendrimers for the delivery of the antibacterial Triclosan [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2008
Many oral care products incorporate an antibacterial compound to prevent the formation of dental plaque which predisposes teeth to dental caries or periodontal disease. Triclosan (TCN) is a commonly used antiplaque agent in toothpastes. Strategies to increase the delivery efficiency of antibacterials using formulation aids such as polyamidoamine (PAMAM)
Gardiner, Jonathan; id_orcid 0000-0003-1827-6817, Freeman, Sally; id_orcid 0000-0002-3831-9151, Leach, Matthew, Green, Alison, Alcock, Jacqui, D'Emanuele, Antony   +5 more
openaire   +3 more sources

PAMAM-Calix-Dendrimers: Second Generation Synthesis, Fluorescent Properties and Catecholamines Binding

Pharmaceutics, 2022
A convenient method for the synthesis of the second generation of PAMAM dendrimers based on a p-tert-butylthiacalix[4]arene core in cone, partial cone and 1,3-alternate conformations was developed.
Olga Mostovaya, Igor Shiabiev, Dmitry Pysin, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Pavel Padnya, Ivan Stoikov   +7 more
doaj   +1 more source

PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis.

Materials Science and Engineering C: Materials for Biological Applications, 2021
Rheumatoid arthritis is a chronic autoimmune disease characterised by joint synovial inflammation, along with cartilage and bone tissue destruction. Dendrimers can offer new opportunities as drug delivery systems of molecules of interest. Herein we aimed
I. Oliveira, C. Gonçalves, Eduarda P Oliveira, R. Simón‐Vázquez, Alain da Silva Morais, Á. González-Fernández, R. Reis, J. Oliveira   +7 more
semanticscholar   +1 more source

FRAGMENTATION OF PAMAM DENDRIMERS IN METHANOL

Proceedings of the Estonian Academy of Sciences. Chemistry, 2001
. The decomposition of ethylenediamine core poly(amidoamine) (PAMAM) dendrimers (generation -0.5) was investigated by gas chromatography. The decomposition of PAMAM dendrimer G-0.5 into triester 2 is caused by the retro-Michael reaction.
Janek Peterson, Veiko Allikmaa, Tõnis Pehk, Margus Lopp   +3 more
openaire   +2 more sources