Results 11 to 20 of about 42,023 (262)

Cationic PAMAM Dendrimers Disrupt Key Platelet Functions [PDF]

Molecular Pharmaceutics, 2012
Poly(amidoamine) (PAMAM) dendrimers have been proposed for a variety of biomedical applications and are increasingly studied as model nanomaterials for such use. The dendritic structure features both modular synthetic control of molecular size and shape and presentation of multiple equivalent terminal groups.
Clinton F, Jones, Robert A, Campbell, Zechariah, Franks, Christopher C, Gibson, Giridhar, Thiagarajan, Adriana, Vieira-de-Abreu, Sivaprasad, Sukavaneshvar, S Fazal, Mohammad, Dean Y, Li, Hamidreza, Ghandehari, Andrew S, Weyrich, Benjamin D, Brooks, David W, Grainger   +12 more
openaire   +4 more sources

Glycosylation of PAMAM dendrimers significantly improves tumor macrophage targeting and specificity in glioblastoma. [PDF]

J Control Release, 2021
Sharma R, Liaw K, Sharma A, Jimenez A, Chang M, Salazar S, Amlani I, Kannan S, Kannan RM.   +8 more
europepmc   +2 more sources

Modified Carboxyl-Terminated PAMAM Dendrimers as Great Cytocompatible Nano-Based Drug Delivery System. [PDF]

Int J Mol Sci, 2019
Polyamidoamine (PAMAM) dendrimers are extensively researched as potential drug delivery system thanks to their desirable features such as controlled and stable structures, and ease of functionalization onto their surface active groups.
Vu MT, Bach LG, Nguyen DC, Ho MN, Nguyen NH, Tran NQ, Nguyen DH, Nguyen CK, Hoang Thi TT.   +8 more
europepmc   +2 more sources

PAMAM dendrimers as promising nanocarriers for RNAi therapeutics [PDF]

, 2015
Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging.
P. Kesharwani, Sanjeev Banerjee, U. Gupta, M. Amin, S. Padhye, F. Sarkar, A. Iyer   +6 more
semanticscholar   +3 more sources

Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization

Nanomaterials, 2017
One of the most studied nanocarriers for drug delivery are polyamidoamine (PAMAM) dendrimers. However, the alterations produced by PAMAM dendrimers in neuronal function have not been thoroughly investigated, and important aspects such as effects on ...
Felipe Vidal, Pilar Vásquez, Francisca R. Cayumán, Carola Díaz, Jorge Fuentealba, Luis G. Aguayo, Gonzalo E. Yévenes, Joel Alderete, Leonardo Guzmán   +8 more
doaj   +2 more sources

The Current State of the Art in PAMAM and PLL Dendrimers, Boron Clusters, and Their Complexes for Biomedical Use [PDF]

Biomedicines
Poly(amidoamine) (PAMAM) and poly-L-lysine (PLL) dendrimers have emerged as highly versatile macromolecular platforms with significant potential in biomedical applications, owing to their well-defined architecture, tunable surface chemistry, and capacity
Agnieszka Maria Kołodziejczyk, Edyta Błaszczyk, Bolesław T. Karwowski   +2 more
doaj   +2 more sources

Conjugation of Gentamicin to Polyamidoamine Dendrimers Improved Anti-bacterial Properties against Pseudomonas aeruginosa [PDF]

Advanced Pharmaceutical Bulletin, 2021
Purpose: This study aimed to design gentamicin-conjugated poly (amidoamine) (PAMAM) dendrimers to increase the therapeutic efficiency of gentamicin against Pseudomonas aeruginosa.
Hamed Sheykhloo, Morteza Milani, Farhood Najafi, Farhad Bani, Amir Zarebkohan   +4 more
doaj   +1 more source

Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential.

Advanced Drug Delivery Reviews, 2021
Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level.
Hadeel Kheraldine, Ousama Rachid, A. Habib, A. Al Moustafa, I. Benter, S. Akhtar   +5 more
semanticscholar   +1 more source

PAMAM dendrimers with dual-conjugated vancomycin and Ag-nanoparticles do not induce bacterial resistance and kill vancomycin-resistant staphylococci.

Acta Biomaterialia, 2021
The effective life-time of new antimicrobials until the appearance of the first resistant strains is steadily decreasing, which discourages incentives for commercialization required for clinical translation and application.
Guimei Jiang, Sidi Liu, Tianrong Yu, Renfei Wu, Yijin Ren, H. C. van der Mei, Jian Liu, H. Busscher   +7 more
semanticscholar   +1 more source

High Fluorescent Porphyrin-PAMAM-Fluorene Dendrimers [PDF]

Molecules, 2015
Two new classes of dendrimers bearing 8 and 32 fluorene donor groups have been synthesized. The first and second generations of these porphyrin-PAMAM-fluorene dendrimers were characterized by 1H-NMR, 13C-NMR, FTIR, UV-vis spectroscopy, elemental analyses and MALDI-TOF mass spectrometry.
Garfias-Gonzalez, Karla, Organista-Mateos, Ulises, Borja-Miranda, Andrés, Gomez-Vidales, Virginia, Hernandez-Ortega, Simon, Cortez-Maya, Sandra, Martínez-García, Marcos   +6 more
openaire   +3 more sources