Acetylation of PAMAM dendrimers for cellular delivery of siRNA [PDF]
BMC Biotechnology, 2009 Background The advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications ...
Uhrich Kathryn E +3 more
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Intrinsic Fluorescence of PAMAM Dendrimers-Quenching Studies. [PDF]
Polymers (Basel), 2018 Intrinsic, non-traditional fluorescence of polyamidoamine (PAMAM) dendrimers that do not possess classical fluorophores has been attracting considerable interest for the last decade. Many hypotheses regarding the source of the fluorescence have appeared,
Konopka M +2 more
europepmc +5 more sources
Inverse Polyamidoamine (i‐PAMAM) Dendrimer Antimicrobials [PDF]
Helvetica Chimica Acta, 2023 Here we redesigned the branches of polyamidoamine (PAMAM) dendrimers by moving the amide carbonyl group on the other side of the amide nitrogen atom, transforming the β-alaninyl-amidoethylamine branch, which easily undergoes retro-Michael reactions and ...
Etienne Bonvin +3 more
core +4 more sources
Selective Cellular Uptake and Druggability Efficacy through Functionalized Chitosan-Conjugated Polyamidoamine (PAMAM) Dendrimers [PDF]
SensorsNanotechnology has ushered in significant advancements in drug design, revolutionizing the prevention, diagnosis, and treatment of various diseases. The strategic utilization of nanotechnology to enhance drug loading, delivery, and release has garnered ...
Ye Hu, Jian Chen, Wenyan Hu
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Curcumin encapsulated in PAMAM dendrimers for the therapeutic treatment of ischemic stroke in rats [PDF]
Frontiers in Cell and Developmental BiologyIntroductionIschemic stroke is a devastating neurovascular condition that occurs when cerebral tissue fails to receive an adequate supply of oxygen. Despite being a leading cause of death and disability worldwide, therapeutic interventions are currently ...
Justin Stadler +25 more
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High Fluorescent Porphyrin-PAMAM-Fluorene Dendrimers [PDF]
Molecules, 2015 Two new classes of dendrimers bearing 8 and 32 fluorene donor groups have been synthesized. The first and second generations of these porphyrin-PAMAM-fluorene dendrimers were characterized by 1H-NMR, 13C-NMR, FTIR, UV-vis spectroscopy, elemental analyses
Karla Garfias-Gonzalez +7 more
core +4 more sources
Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment? [PDF]
Pharmaceutics, 2023 Based on their drug delivery properties and activity against tumors, we combined PAMAM dendrimers with various platinum(IV) complexes in order to provide an improved approach of anticancer treatment.
Yvonne Lerchbammer-Kreith +6 more
doaj +2 more sources
Hydrogel of Ketoconazole and PAMAM Dendrimers: Formulation and Antifungal Activity
Molecules, 2012 Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages.
Elzbieta Tryniszewska +4 more
doaj +2 more sources
PAMAM dendrimers as efficient drug nanocarriers of natural compounds in breast cancer therapeutics [PDF]
Frontiers in OncologyBreast cancer is among the most prevalent cancers in women and leads to significant mortality worldwide. It remains a global health issue, affecting millions of women annually despite progress in diagnosis and treatment.
Syed Gulfishan +7 more
doaj +2 more sources
From Structure to Function: The Promise of PAMAM Dendrimers in Biomedical Applications [PDF]
PharmaceuticsPAMAM dendrimers are distinguished by their capacity for functionalization, which enhances the properties of the compounds they transport, rendering them highly versatile nanoparticles with extensive applications in the biomedical domain, including drug,
Said Alamos-Musre +9 more
doaj +2 more sources