Results 41 to 50 of about 23,036 (202)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Selective cytotoxicity of PAMAM G5 core-PAMAM G2.5 shell tecto-dendrimers on melanoma cells [PDF]

, 2012
The controlled introduction of covalent linkages between dendrimer building blocks leads to polymers of higher architectural order known as tecto-dendrimers.
Mundiña, Cecilia Beatriz, Romero, Eder Lilia, Mundiña-Weilenmann, Cecilia, Schilrreff, Priscila, Romero, Eder Lidia, Morilla, María José   +5 more
core   +1 more source

Structural Optimization of Carboxy-Terminal Phenylalanine-Modified Dendrimers for T-Cell Association and Model Drug Loading

Pharmaceutics
Dendrimers are potent nanocarriers in drug delivery systems because their structure can be precisely controlled. We previously reported that polyamidoamine (PAMAM) dendrimers that were modified with 1,2-cyclohexanedicarboxylic acid (CHex) and ...
Hiroya Shiba, Tomoka Hirose, Akinobu Sakai, Ikuhiko Nakase, Akikazu Matsumoto, Chie Kojima   +5 more
doaj   +1 more source

Modified Surfaces with Nano-Structured Composites of Prussian Blue and Dendrimers. New Materials for Advanced Electrochemical Applications

International Journal of Electrochemical Science, 2011
In this work, the basic theory and the applications of modified surfaces with nano-structured composites of Prussian Blue (PB) and Dendrimers, for the electrochemical detectors and electrocatalyze technologies, currently, represent some of the most ...
Erika Bustos, Luis A. Godínez
doaj   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

PAMAM-Based Dendrimers with Different Alkyl Chains Self-Assemble on Silica Surfaces: Controllable Layer Structure and Molecular Aggregation

, 2018
Amphiphilic poly­(amidoamine) (PAMAM) dendrimers are a well-known dendritic family due to their remarkable ability to self-assemble on solid surface. However, the relationship between molecular conformation (or adsorption kinetics) of a self-assembled ...
Ting Chen (15205), Donghong Guo (3228261), Minghui Zhang (298745), Wei Zhang (405), Jinben Wang (1361514), Fanghui Liu (1361523), Xu Wu (318848), Qingfeng Hou (1753471), Hui Yang (91136), Shujuan Wang (30858)   +9 more
core   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Synthesis and Characterization of Poly(Amidoamine) Dendrimers Encapsulatd 198Au Nanoparticles

Atom Indonesia, 2012
Brachytherapy or internal radiotherapy is one of many methods used for treatment of cancer. This modality requires an agent with radionuclides that emits  or β particle with a proper energy.
R. Ritawidya1,2, A. Pujiyanto2,, Mujinah2, ,, Witarti2, , H. Setiawan2, , M. Ramli2, , D. Kurniasih2, , A. Yanuar1,, A. Mutalib2, L.B. Kardono3   +9 more
doaj  

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

Molecules, 2018
Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties.
Daniel M. Shadrack, Hulda S. Swai, Joan J. E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro   +4 more
doaj   +1 more source