Results 51 to 60 of about 42,023 (262)

Slow-Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer. [PDF]

, 2018
The plant viral nanoparticle cowpea mosaic virus (CPMV) is shown to be an effective immunotherapy for ovarian cancer when administered as in situ vaccine weekly, directly into the intraperitoneal (IP) space in mice with disseminated tumors.
Aguirre, Albertazzi, Bysell, Callahan, Cho, Cho, Conejo-Garcia, Corrales, Czapar, Dobrovolskaia, Emoto, Fransen, Hammerich, Jayson, Kostiainen, Kostiainen, LeBlond, Lin, Lizotte, Lomonossoff, Mikkilä, Mukherjee, Pandita, Pardoll, Pierce, Prokop, Singh, Smet, Stefano, Sun, Susman, Umeki, Veliz, Wallat, Wang, Wen, Wen, Wen, Winograd, Wright, Xu, Yoon   +41 more
core   +2 more sources

Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios [PDF]

Materials Today Communications, 2015
The synthesis, isolation, and characterization of generation 3 poly(amidoamine) (G3 PAMAM) dendrimer containing precise ratios of 5-carboxytetramethylrhodamine succinimidyl ester (TAMRA) dye (n = 1-3) per polymer particle are reported. Stochastic conjugation of TAMRA dye to the dendrimer was followed by separation into precise dye-polymer ratios using ...
Janet, Manono, Casey A, Dougherty, Kirsten, Jones, Joshua, DeMuth, Mark M Banaszak, Holl, Stassi, DiMaggio   +5 more
openaire   +2 more sources

The Effect of PAMAM Dendrimers on the Antibacterial Activity of Antibiotics with Different Water Solubility

Molecules, 2013
Erythromycin (EM) and tobramycin (TOB) are well-known and widely used antibiotics, belonging to different therapeutic groups: macrolide and aminoglycoside, respectively.
Elzbieta Anna Tryniszewska, Pawel Tomasz Sacha, Piotr Wieczorek, Magdalena Wroblewska, Katarzyna Winnicka   +4 more
doaj   +1 more source

Effect of the Generation of PAMAM Dendrimers on the Stabilization of Gold Nanoparticles

Journal of Chemical Information and Modeling, 2020
The behavior of small and intermediate generations of poly(amidoamine) (PAMAM) dendrimers and PAMAM|gold nanocomposites was studied by computational tools and experimental techniques. Molecular dynamics simulations were used to characterize at the atomic
F. Ávila-Salas, R. González, P. Ríos, Ingrid Araya-Durán, M. B. Camarada   +4 more
semanticscholar   +1 more source

Condensation transition in DNA-polyaminoamide dendrimer fibers studied using optical tweezers [PDF]

, 2006
When mixed together, DNA and polyaminoamide (PAMAM) dendrimers form fibers that condense into a compact structure. We use optical tweezers to pull condensed fibers and investigate the decondensation transition by measuring force-extension curves (FECs ...
C. Bustamante, C. G. Baumann, F. Ritort, G. I. Bell, J. F. Marko, S. B. Smith, S. Mihardja   +6 more
core   +2 more sources

The Effect of Absorption-Enhancement and the Mechanism of the PAMAM Dendrimer on Poorly Absorbable Drugs

Molecules, 2018
The polyamidoamine (PAMAM) dendrimer is a highly efficient absorption promoter. In the present study, we studied the absorption-enhancing effects and the mechanism of PAMAM dendrimers with generation 0 to generation 3 (G0–G3) and concentrations (0 ...
Juan Lu, Nannan Li, Yaochun Gao, Nan Li, Yifei Guo, Haitao Liu, Xi Chen, Chunyan Zhu, Zhengqi Dong, Akira Yamamoto   +9 more
doaj   +1 more source

Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy

Pharmaceutics, 2018
We present here the development of multifunctional doxorubicin (DOX)-conjugated poly(amidoamine) (PAMAM) dendrimers as a unique platform for pH-responsive drug release and targeted chemotherapy of cancer cells.
Mengen Zhang, Jingyi Zhu, Yun Zheng, Rui Guo, Shige Wang, S. Mignani, A. Caminade, J. Majoral, Xiangyang Shi   +8 more
semanticscholar   +1 more source

Molecular modeling to study dendrimers for biomedical applications [PDF]

, 2014
© 2014 by the authors; licensee MDPI; Basel; Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Buhleier, Carbone, Florida, Helena Florindo, Hess, Klajnert, Liana Silva, Mire Zloh, Nuno Martinho, Radhika, Shaunak, Shcharbin, Steve Brocchini, Teresa Barata, Tomalia, Šebestík   +15 more
core   +4 more sources

Dendrimers for Drug Delivery

Molecules, 2018
Dendrimers have come a long way in the last 25 years since their inception. Originally created as a wonder molecule of chemistry, dendrimer is now in the fourth class of polymers. Dr.
Abhay Singh Chauhan
doaj   +1 more source

Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model

Journal of Controlled Release, 2018
&NA; Neurotherapeutics for the treatment of central nervous system (CNS) disorders must overcome challenges relating to the blood‐brain barrier (BBB), brain tissue penetration, and the targeting of specific cells.
Anjali Sharma, Joshua E. Porterfield, Elizabeth S. Smith, Rishi Sharma, S. Kannan, R. Kannan   +5 more
semanticscholar   +1 more source