Results 71 to 80 of about 42,023 (262)

Structural Optimization of Carboxy-Terminal Phenylalanine-Modified Dendrimers for T-Cell Association and Model Drug Loading

Pharmaceutics
Dendrimers are potent nanocarriers in drug delivery systems because their structure can be precisely controlled. We previously reported that polyamidoamine (PAMAM) dendrimers that were modified with 1,2-cyclohexanedicarboxylic acid (CHex) and ...
Hiroya Shiba, Tomoka Hirose, Akinobu Sakai, Ikuhiko Nakase, Akikazu Matsumoto, Chie Kojima   +5 more
doaj   +1 more source

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

Molecules, 2018
Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties.
Daniel M. Shadrack, Hulda S. Swai, Joan J. E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro   +4 more
doaj   +1 more source

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Practical computational toolkits for dendrimers and dendrons structure design [PDF]

, 2017
Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and ...
A Kwok, A Quintana, AM Naylor, BP Roberts, C Yu, CD Schwieters, CW Brown, D Astruc, D Jishkariani, D Luong, DA Case, E Vacas-Córdoba, F Razmimanesh, G Kleywegt, G Kleywegt, H Arima, H-J Hsu, Helena F. Florindo, HJC Berendsen, HM Berman, I Jatczak-Pawlik, I Tanis, JC Phillips, K Öztürk, KT Al-Jamal, LF Pinto, LF Pinto, Liana C. Silva, M Bello, M Kalomiraki, M Zloh, Mire Zloh, MK Mishra, N Li, N Martinho, Nuno Martinho, R Alberto, S Ahmed, S Dong, S Ghosh, S Javor, S Raut, S Svenson, SH Kim, Steve Brocchini, Teresa Barata, TS Barata, TS Barata, TS Barata, TTC Nguyen, V Maingi, X Cai, Y Liu   +52 more
core   +3 more sources

Visualization of Endosomal Escape of Intracellularly Delivered Protein With Unexpected Photochemical Internalization of Trypan Blue

Advanced Science, EarlyView.
TB, a conventional cell viability dye, acts as both a fluorescence modulator (quenching GFP fluorescence upon protein binding and recovering it upon release) and a photosensitizer that triggers endosomal escape via photochemical internalization (PCI) under 590 nm light.
Zhongqi Yao, Zhan Shi, Peng Hu, Changping Wang, Hui Wang   +4 more
wiley   +1 more source

Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]

, 2011
Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L., Bartlett D. W., Blessing T., Boeckle S., Boussif O., Carboni B., Carlin C. R., Choi J. S., Christian Dohmen, Davis M. E., Davis M. E., de Bruin K., Ernst Wagner, Esfand R., Haijun Yu, Hua C., Iyer J., Kannan R. M., Kataoka K., Kircheis R., Kircheis R., Kloeckner J., Kloeckner J., Kursa M., Lee J. W., Li S. D., Luo D., Lutz J. F., Maeda H., Maiti P. K., Meyer M., Navarro G., Nie Y., Ogris M., Plank C., Plank C., Russ V., Russ V., Russ V., Schaffert D., Shir A., Simoes S., Svenson S., Tomalia D. A., Tomalia D. A., von Gersdorff K., Wagner E., Wagner E., Walker G. F., Wolschek M. F., Wood K. C., Yellepeddi V. K., Yu H., Yu H., Yu Nie, Yunqiu Li, Zhang X. Q., Zhao X., Zou S. M., Zugates G. T.   +59 more
core   +1 more source

Fluorinated Amphiphilic Dendrimer to Improve PET Imaging of Cancer

Small, EarlyView.
Fluorination of a self‐assembling dendrimer nanosystem reduced liver retention, accelerated renal clearance and improved biodistribution, ultimately enhancing tumor uptake and enabling more sensitive tumor detection by positron emission tomography (PET).
Béatrice Louis, Tom Roussel, Twiany Cruz‐Dubois, Ling Ding, Zhenbin Lyu, Erik Laurini, Jessica Ou, Laure Balasse, Adrien Chabert, Vincent Nail, Ahlem Bouhlel, Françoise Dignat‐George, Florence Gattacceca, Sabrina Pricl, Benjamin Guillet, Ling Peng, Philippe Garrigue   +16 more
wiley   +1 more source

Structure of DNA-Functionalized Dendrimer Nanoparticles

, 2012
Atomistic molecular dynamics simulations have been carried out to reveal the characteristic features of ethylenediamine (EDA) cored protonated poly amido amine (PAMAM) dendrimers of generation 3 (G3) and 4 (G4) that are functionalized with single ...
Aldaye, Alivisatos, Bao, Berendsen, Blab, Bliznyuk, Carbone, Choi, Choi, Condon, Dai, Dai, Duan, Esfand, Feldkamp, Gurtovenko, Hainfeld, Hill, Hsu, Huang, Hurst, Jain, Jain, Jorgensen, Kalogianni, Karatasos, Ke, Klos, Lara, Largo, Lee, Lee, Lee, Lee, Li, Liu, Lu, Lyulin, Macfarlane, Maiti, Maiti, Maiti, Maiti, Maiti, Mattaparthi Venkata Satish Kumar, Mayo, Mijovic, Mirkin, Mizutani, Nandy, Niemeyer, Niemeyer, Nykypanchuk, Paciotti, Padovan-Merhar, Park, Park, Pearlman, Prabal K Maiti, Rosi, Rosi, Ryckaert, Seeman, Sosinsky, Starr, Stechemesser, Storhoff, Suek, Sun, Thankappan, Tomalia, Tomalia, Tomalia, Tomalia, Tomalia, Uppuluri, Vasumathi, Xiong, Zhao   +78 more
core   +1 more source

Superelastic and pH-Responsive Degradable Dendrimer Cryogels Prepared by Cryo-aza-Michael Addition Reaction [PDF]

, 2018
Dendrimers exhibit super atomistic features by virtue of their well-defined discrete quantized nanoscale structures. Here, we show that hyperbranched amine-terminated polyamidoamine (PAMAM) dendrimer G4.0 reacts with linear polyethylene glycol (PEG ...
Wang, Juan, Yang, Hu
core   +3 more sources

Synthesis and Characterization of Poly(Amidoamine) Dendrimers Encapsulatd 198Au Nanoparticles

Atom Indonesia, 2012
Brachytherapy or internal radiotherapy is one of many methods used for treatment of cancer. This modality requires an agent with radionuclides that emits  or β particle with a proper energy.
R. Ritawidya1,2, A. Pujiyanto2,, Mujinah2, ,, Witarti2, , H. Setiawan2, , M. Ramli2, , D. Kurniasih2, , A. Yanuar1,, A. Mutalib2, L.B. Kardono3   +9 more
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