Results 81 to 90 of about 23,036 (202)

Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells [PDF]

, 2011
We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with alpha-cyclodextrin (alpha-CyD) having an average degree of substitution of 2.4 of alpha-CyD (alpha-CDE) provided remarkable aspects as novel ...
Masayo Arizono, Fumitoshi Hirayama, Hidetoshi Arima, Haruna Ikeda, Tomoko Takeuchi, Kaneto Uekama, Taishi Higashi, Ayumi Yoshimitsu, Kenjiro Hattori, Keiichi Motoyama   +9 more
core  

PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy

European Journal of Medicinal Chemistry, 2013
Platelets are anucleated blood cells that play an important role both in the pathogenesis of atherosclerosis and subsequent thrombosis. Dendrimers have attracted great interest in biomedical applications. However, their interactions with cell compounds and compartments are nonselective, thus causing cytotoxicity and hemotoxicity.
Duran-Lara, Esteban, Guzman, Luis, John, Amalraj, Fuentes, Eduardo, Alarcon, Marcelo, Palomo, Ivan, Santos, Leonardo S.   +6 more
openaire   +4 more sources

PAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding

Pharmaceutics
Background/Objectives: Current promising treatments for many diseases are based on the use of therapeutic nucleic acids, including DNA. However, the list of nanocarriers is limited due to their low biocompatibility, high cost, and toxicity. The design of
Olga Mostovaya, Igor Shiabiev, Daniil Ovchinnikov, Dmitry Pysin, Timur Mukhametzyanov, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Arthur Khannanov, Marianna Kutyreva, Mingwu Shen, Xiangyang Shi, Pavel Padnya, Ivan Stoikov   +13 more
doaj   +1 more source

Recent Research Progress on Polyamidoamine-Engineered Hydrogels for Biomedical Applications

Biomolecules
Hydrogels are three-dimensional crosslinked functional materials with water-absorbing and swelling properties. Many hydrogels can store a variety of small functional molecules to structurally and functionally mimic the natural extracellular matrix; hence,
Li Liu, Zhiling Li, Baiyan Yang, Xiaoqing Jia, Shige Wang   +4 more
doaj   +1 more source

Convergent Synthesis of Internally Branched PAMAM Dendrimers

, 2016
A series of aliphatic internally branched poly(amido amine) dendrons and dendrimers has been synthesized. The internal branching unit was 1,2-propanediamine and a series of PAMAM-type dendrons of the types AB2, AB4, and AB8 were built.
Michael Pittelkow (1357116), Jørn B. Christensen (386744)   +1 more
core   +1 more source

Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA

Pharmaceutics, 2012
Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins ...
Hidetoshi Arima, Keiichi Motoyama, Taishi Higashi   +2 more
doaj   +1 more source

Selective cytotoxicity of PAMAM G5 core–PAMAM G2.5 shell tecto-dendrimers on melanoma cells

, 2012
Priscila Schilrreff,1 Cecilia Mundiña-Weilenmann,2 Eder Lilia Romero,1 Maria Jose Morilla11Programa de Nanomedicinas, Universidad Nacional de Quilmes, Buenos Aires, Argentina; 2Centro de Investigaciones Cardiovasculares, Universidad Nacional ...
Schilrreff P, Morilla MJ, Mundiña-Weilenmann C, Romero EL   +3 more
core  

PAMAM-calix-dendrimers as carriers for 5-fluorouracil: complexation, aggregation, and in vitro antitumor activity

Chimica Techno Acta
Despite a number of serious challenges and limitations in clinical use, drug therapy is considered one of the most common approaches to treating cancer. However, many types of cancer become resistant to antitumor drugs.
Pavel Padnya, Ilona Svintsova, Igor Shiabiev, Dmitry Pysin, Olga Mostovaya, Bahdan Ranishenka, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Anastasia Nazarova, Ivan Stoikov   +10 more
doaj   +1 more source

Cationic PAMAM Dendrimers as Pore-Blocking Binary Toxin Inhibitors

, 2015
Dendrimers are unique highly branched macromolecules with numerous groundbreaking biomedical applications under development. Here we identified poly­(amido amine) (PAMAM) dendrimers as novel blockers for the pore-forming B components of the binary ...
Fabienne Bayer (1326318), Holger Barth (152879), Philip Förstner (1326336), Susanne Felsen (1326321), Ekaterina M. Nestorovich (345817), Nnanya Kalu (1326324), Christina Förtsch (1326330), Abrar Aloufi (1326333), Tanja Weil (1326315), David Y. W. Ng (1326327)   +9 more
core   +1 more source

PEG Conjugated PAMAM Dendrimers with a Anti- HIV Drug Stavudine for prolong release [PDF]

, 2013
The present investigation was aimed to design polyamidoamine (PAMAM) dendrimer having polyethylene glycol grafts as novel drug carrier. In this study we successfully synthesized and conjugated PEGylated PAMAM dendrimers with anti HIV drug stavudine ...
Kumar, P.Vijayaraj, Selvam, T. Panneer, Rao, K.R.S. Sambasiva, Kumar, P. Dinesh   +3 more
core