Results 101 to 110 of about 36,882 (246)
Synthesis and modification of pamam dendrimers as histone replacement molecules
, 2009 The primary objective of this work was to synthesise and structurally modify a series of PAMAM dendrimers with a view to investigating and controlling their complexation with, and compaction of, DNA.
Jenkins, Alan
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, Volume 16, Issue 5, Page 944-965, May 2026.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Convergent Synthesis of Internally Branched PAMAM Dendrimers
, 2016 A series of aliphatic internally branched poly(amido amine) dendrons and dendrimers has been synthesized. The internal branching unit was 1,2-propanediamine and a series of PAMAM-type dendrons of the types AB2, AB4, and AB8 were built.
Michael Pittelkow (1357116) +1 more
core +1 more source
PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy
European Journal of Medicinal Chemistry, 2013 Platelets are anucleated blood cells that play an important role both in the pathogenesis of atherosclerosis and subsequent thrombosis. Dendrimers have attracted great interest in biomedical applications. However, their interactions with cell compounds and compartments are nonselective, thus causing cytotoxicity and hemotoxicity.
Duran-Lara, Esteban +6 more
openaire +4 more sources
PAMAM dendrimers as promising nanocarriers for RNAi therapeutics
, 2015 Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging.
P. Kesharwani +6 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2017 Drug delivery into the central nervous system (CNS) is challenging due to the blood–brain barrier (BBB) and drug delivery into the brain overcoming the BBB can be achieved using nanoparticles such as dendrimers.
B. Srinageshwar +17 more
semanticscholar +1 more source
Cationic PAMAM Dendrimers as Pore-Blocking Binary Toxin Inhibitors
, 2015 Dendrimers are unique highly branched macromolecules with numerous groundbreaking biomedical applications under development. Here we identified poly(amido amine) (PAMAM) dendrimers as novel blockers for the pore-forming B components of the binary ...
Fabienne Bayer (1326318) +9 more
core +1 more source
Recent Research Progress on Polyamidoamine-Engineered Hydrogels for Biomedical Applications
BiomoleculesHydrogels are three-dimensional crosslinked functional materials with water-absorbing and swelling properties. Many hydrogels can store a variety of small functional molecules to structurally and functionally mimic the natural extracellular matrix; hence,
Li Liu +4 more
doaj +1 more source
Selective cytotoxicity of PAMAM G5 core–PAMAM G2.5 shell tecto-dendrimers on melanoma cells
, 2012 Priscila Schilrreff,1 Cecilia Mundiña-Weilenmann,2 Eder Lilia Romero,1 Maria Jose Morilla11Programa de Nanomedicinas, Universidad Nacional de Quilmes, Buenos Aires, Argentina; 2Centro de Investigaciones Cardiovasculares, Universidad Nacional ...
Schilrreff P +3 more
core
Interactions of PAMAM Dendrimers with SDS at the Solid–Liquid Interface
Langmuir, 2013 This work addresses structural and nonequilibrium effects of the interactions between well-defined cationic poly(amidoamine) PAMAM dendrimers of generations 4 and 8 and the anionic surfactant sodium dodecyl sulfate (SDS) at the hydrophilic silica-water interface.
Yanez Arteta, Marianna +3 more
openaire +3 more sources