Results 111 to 120 of about 42,023 (262)

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

PAMAM dendrimer for mitigating humic foulant

RSC Advances, 2012
Poly(amidoamine) (PAMAM) dendrimers have been established as efficient ligands for the removal of humic acid (HA) foulant, based upon electrostatic and hydrophobic interactions, as well as hydrogen bonding. This proof-of-concept study indicates the broad utility of dendritic nanotechnology for water treatment and environmental applications.
Priyanka Bhattacharya, Nathan Conroy, Apparao M. Rao, Brian A. Powell, David A. Ladner, Pu Chun Ke   +5 more
openaire   +1 more source

Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He, Mengyao Qu, Lu Yu, Lipeng He, Yixun Lu, Jin Hong, Miao Sun, Huikai Yang, Weidong Mi, Hang Guo, Yulong Ma   +10 more
wiley   +1 more source

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells.

Journal of Toxicological Sciences, 2016
Polyamidoamine (PAMAM) dendrimers have potential for biological applications as delivery systems for genes, drugs, and imaging agents into the brain, but their developmental neurotoxicity remains unknown.
Yang Zeng, Y. Kurokawa, Tin-Tin Win-Shwe, Qin Zeng, S. Hirano, Zhenya Zhang, H. Sone   +6 more
semanticscholar   +1 more source

Molecular modelling of dendrimers for nanoscale applications [PDF]

, 2000
Dendrimers are well defined, highly branched macromolecules that radiate from a central core and are synthesized through a stepwise, repetitive reaction sequence that guarantees complete shells for each generation, leading to polymers that are ...
Breen, Nicholas, Goddard, William A., III, Martin, Ryan, Wang, Guofeng, Çağin, Tahir   +4 more
core  

Polyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue [PDF]

, 2013
Background: The potential nanocarrier polyamidoamine (PAMAM) generation 5 (G5-NH2) dendrimer has been shown to evoke lasting neuronal depolarization and cell death in a concentration-dependent manner. In this study we explored the early progression of G5-
Benéné Visy, Júlia, Héja, László, Jablonkai, István, Kardos, Julianna, Nyitrai, Gabriella, Pál, Ildikó   +5 more
core   +1 more source

Organic Nanoparticles in Food Systems as Antimicrobial Agents: Synthesis Strategies, Functional Properties, and Biofilm Inhibition Mechanisms

Nano Select, Volume 7, Issue 4, April 2026.
Organic nanoparticles (ONPs) derived from biopolymers provide sustainable antimicrobial platforms with tunable physicochemical properties. By enabling controlled delivery of bioactive compounds, ONPs disrupt microbial membranes, induce oxidative stress, and inhibit quorum sensing.
Huy Loc Nguyen, Thi Bich Ngoc Nguyen
wiley   +1 more source

Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells [PDF]

, 2011
We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with alpha-cyclodextrin (alpha-CyD) having an average degree of substitution of 2.4 of alpha-CyD (alpha-CDE) provided remarkable aspects as novel ...
Ayumi Yoshimitsu, Fumitoshi Hirayama, Haruna Ikeda, Hidetoshi Arima, Kaneto Uekama, Keiichi Motoyama, Kenjiro Hattori, Masayo Arizono, Taishi Higashi, Tomoko Takeuchi   +9 more
core   +1 more source

Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis [PDF]

, 2017
Current atherosclerosis treatment strategies primarily focus on limiting further cholesteryl esters (CE) accumulation by reducing endogenous synthesis of cholesterol in the liver.
Ghosh, Shobha, He, Hongliang, Korzun, William J., Lancina, Michael G., III, Wang, Jing, Yang, Hu   +5 more
core   +2 more sources

PAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding

Pharmaceutics
Background/Objectives: Current promising treatments for many diseases are based on the use of therapeutic nucleic acids, including DNA. However, the list of nanocarriers is limited due to their low biocompatibility, high cost, and toxicity. The design of
Olga Mostovaya, Igor Shiabiev, Daniil Ovchinnikov, Dmitry Pysin, Timur Mukhametzyanov, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Arthur Khannanov, Marianna Kutyreva, Mingwu Shen, Xiangyang Shi, Pavel Padnya, Ivan Stoikov   +13 more
doaj   +1 more source