Results 111 to 120 of about 36,882 (246)

Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA

Pharmaceutics, 2012
Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins ...
Hidetoshi Arima, Keiichi Motoyama, Taishi Higashi   +2 more
doaj   +1 more source

PAMAM Dendrimers with an Oxyethylene Unit-Enriched Surface as Biocompatible Temperature-Sensitive Dendrimers

, 2016
A novel type of temperature-sensitive dendrimer was synthesized using one-step terminal modification of polyamidoamine dendrimers (PAMAM) with various alkoxy diethylene glycols such as methoxy diethylene glycol, ethoxy diethylene glycol, and propoxy ...
Atsushi Harada (1553569), Kanako Ochi (1989658), Eiji Yuba (1553575), Yasuhiro Haba (1989661), Kenji Kono (1553572), Xiaojie Li (250749)   +5 more
core   +1 more source

PAMAM-Functionalized Paper as a New Substrate for the Paper Spray Mass Spectrometry Measurement of Proteins

, 2023
Paper surface functionalization with polyamidoamine (PAMAM) dendrimers has been developed for increased sensitivity analysis of proteins by paper spray mass spectrometry (PS-MS).
Joseph Monaghan, Igor Pereira (6616913), Joseph Monaghan (6163250), Igor Pereira, Lucas R. Abruzzi (15373852), Chris G. Gill, Lucas R. Abruzzi, Chris G. Gill (4006127)   +7 more
core   +1 more source

Cationic PAMAM Dendrimers Aggressively Initiate Blood Clot Formation

, 2016
Poly(amidoamine) (PAMAM) dendrimers are increasingly studied as model nanoparticles for a variety of biomedical applications, notably in systemic administrations.
Amanda E. Brooks (714087), Robert A. Campbell (197299), Shoeleh Assemi (2019166), David W. Grainger (714086), Hamidreza Ghandehari (1329966), Andrew S. Weyrich (197324), Clinton F. Jones (2019160), Soheyl Tadjiki (2019163), Cheyanne Mulcock (2019169), Giridhar Thiagarajan (1930012), Benjamin D. Brooks (714084)   +10 more
core   +2 more sources

PAMAM-calix-dendrimers as carriers for 5-fluorouracil: complexation, aggregation, and in vitro antitumor activity

Chimica Techno Acta
Despite a number of serious challenges and limitations in clinical use, drug therapy is considered one of the most common approaches to treating cancer. However, many types of cancer become resistant to antitumor drugs.
Pavel Padnya, Ilona Svintsova, Igor Shiabiev, Dmitry Pysin, Olga Mostovaya, Bahdan Ranishenka, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Anastasia Nazarova, Ivan Stoikov   +10 more
doaj   +1 more source

Cholesterol-Conjugated PAMAM Dendrimers: Enhancing Stability, Drug Delivery Efficiency, and In Vitro Anticancer Performance

Nanomaterials offer great potential in cancer treatment, particularly in drug delivery, where their unique properties allow for targeted therapy, increasing treatment efficacy while minimizing side effects.
Luu, CH, Dinh, LTT, Vu, HH, Ly, HQ, Hoang Thi, TT, Nguyen, ML, Nguyen, TKN, Nguyen, CV, Phan, CM, Luu, NHT   +9 more
core   +1 more source

Endocytic Uptake, Transport and Macromolecular Interactions of Anionic PAMAM Dendrimers within Lung Tissue

Pharmaceutical Research, 2017
Polyamidoamine (PAMAM) dendrimers are a promising class of nanocarrier with applications in both small and large molecule drug delivery. Here we report a comprehensive evaluation of the uptake and transport pathways that contribute to the lung ...
C. Morris, G. Aljayyoussi, Omar T Mansour, P. Griffiths, M. Gumbleton   +4 more
semanticscholar   +1 more source

Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico

Journal of Tropical Pharmacy and Chemistry, 2017
Dendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM).
Yurika Sastyarina, Zuhrotun Nafisah, Muhammad Yusuf, Martalena Ramli, Abdul Mutalib, Ukun Soedjanaatmadja   +5 more
doaj   +1 more source

Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer

Scientific Reports, 2016
Approximately 20% of breast cancer cases are human epidermal growth factor receptor 2 (HER2)-positive. This type of breast cancer is more aggressive and tends to reoccur more often than HER2-negative breast cancer.
H. Kulhari, Deep Pooja, S. Shrivastava, Madhusudana Kuncha, V. Naidu, V. Bansal, R. Sistla, D. Adams, D. Adams   +8 more
semanticscholar   +1 more source

PAMAM dendrimer: a pH-controlled nanosponge [PDF]

Canadian Journal of Chemistry, 2017
Using fully atomistic molecular dynamics simulation that are several hundred nanoseconds long, we demonstrate the pH-controlled sponge action of PAMAM dendrimer. We show how at varying pH levels, the PAMAM dendrimer acts as a wet sponge; at neutral or low pH levels, the dendrimer expands noticeably and the interior of the dendrimer opens up to host ...
openaire   +1 more source