Results 131 to 140 of about 42,023 (262)

PAMAM-calix-dendrimers as carriers for 5-fluorouracil: complexation, aggregation, and in vitro antitumor activity

Chimica Techno Acta
Despite a number of serious challenges and limitations in clinical use, drug therapy is considered one of the most common approaches to treating cancer. However, many types of cancer become resistant to antitumor drugs.
Pavel Padnya, Ilona Svintsova, Igor Shiabiev, Dmitry Pysin, Olga Mostovaya, Bahdan Ranishenka, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Anastasia Nazarova, Ivan Stoikov   +10 more
doaj   +1 more source

Physicochemical and MRI characterization of Gd3+-loaded polyamidoamine and hyperbranched dendrimers [PDF]

, 2018
Generation 4 polyamidoamine (PAMAM) and, for the first time, hyperbranched poly(ethylene imine) or polyglycerol dendrimers have been loaded with Gd3+ chelates, and the macromolecular adducts have been studied in vitro and in vivo with regard to MRI ...
Helm, Lothar, Jászberényi, Zoltán, Kneuer, Rainer, Merbach, André, Moriggi, Loïck, Schmidt, Philipp, Tóth, Éva, Weidensteiner, Claudia   +7 more
core   +1 more source

Origin of broad polydispersion in functionalized dendrimers and its effects on cancer cell binding affinity

, 2010
Nanoparticles with multiple ligands have been proposed for use in nanomedicine. The multiple targeting ligands on each nanoparticle can bind to several locations on a cell surface facilitating both drug targeting and uptake.
Bradford G. Orr, D. Weitman, Douglas G. Mullen, G. D. Titskii, Jack N. Waddell, Leonard M. Sander, Mark M. Banaszak Holl, X. Wang   +7 more
core   +1 more source

One-Step Synthesis of Graphene Oxide-Polyamidoamine Dendrimer Nanocomposite Hydrogels by Self-Assembly [PDF]

, 2016
Graphene oxide (GO)-polyamidoamine (PAMAM) dendrimer nanocomposite hydrogels were prepared through a one-step synthesis by mixing a GO suspension and a PAMAM solution at varying ratios of GO to PAMAM.
Chen, B., Piao, Y., Wu, T.
core   +2 more sources

Engineering PAMAM dendrimers for optimized drug delivery

Nano Trends
Dendrimers, first introduced by Fritz Vögtle in 1978, have emerged as promising nanocarriers for drug delivery due to their unique branched architecture, large internal cavities, and numerous surface amine groups.
Amin Aleebrahim Dehkordi, Shirin Mollazadeh, Amirreza Talaie, Mostafa Yazdimamaghani   +3 more
doaj   +1 more source

Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico

Journal of Tropical Pharmacy and Chemistry, 2017
Dendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM).
Yurika Sastyarina, Zuhrotun Nafisah, Muhammad Yusuf, Martalena Ramli, Abdul Mutalib, Ukun Soedjanaatmadja   +5 more
doaj   +1 more source

Endocytic Uptake, Transport and Macromolecular Interactions of Anionic PAMAM Dendrimers within Lung Tissue

Pharmaceutical Research, 2017
Polyamidoamine (PAMAM) dendrimers are a promising class of nanocarrier with applications in both small and large molecule drug delivery. Here we report a comprehensive evaluation of the uptake and transport pathways that contribute to the lung ...
C. Morris, G. Aljayyoussi, Omar T Mansour, P. Griffiths, M. Gumbleton   +4 more
semanticscholar   +1 more source

In vivo study of dendron-like nanoparticles for stem cells tune-up : from nano to tissues [PDF]

, 2011
The control of stem cell differentiation to obtain osteoblasts in vivo is still regarded as a challenge in stem-cell-based and bone-tissue engineering strategies.
Hirose, Motohiro, Kotobuki, Noriko, Malafaya, P. B., Mano, J. F., Ohgushi, Hajime, Oliveira, Joaquim M., Reis, R. L., Silva, Simone Santos, Sousa, R. A.   +8 more
core   +1 more source

Engineered nanomaterials for biomedical applications [PDF]

, 2014
Engineered nanomaterials (ENM) have emerged as attractive and promising candidates for a wide range of advanced applications including in particular in medicine.
Feliu Torres, Neus
core   +1 more source

Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer

Scientific Reports, 2016
Approximately 20% of breast cancer cases are human epidermal growth factor receptor 2 (HER2)-positive. This type of breast cancer is more aggressive and tends to reoccur more often than HER2-negative breast cancer.
H. Kulhari, Deep Pooja, S. Shrivastava, Madhusudana Kuncha, V. Naidu, V. Bansal, R. Sistla, D. Adams, D. Adams   +8 more
semanticscholar   +1 more source