Results 91 to 100 of about 36,882 (246)

Novel fluorescein isothiocyanate (FITC) cored PAMAM dendrimers as drug delivery agent

, 2023
Fluorescent dyes, or fluorophores, enable researchers to visualize specific biological molecules by fluorescence microscopy. Herein, a novel fluorescent FITC-poly(amidoamine) (FITC-PAMAM) dendrimers have been synthesized via divergent approach.
Bukun, Yalcin, Kiyak, Bercem Yaman, IŞIK, Sevim, Sagir, Tugba, Zaim, Merve, Senel, Mehmet   +5 more
core   +2 more sources

Smart Polymer‐Based Drug Delivery Systems for Managing Infective Conjunctivitis: Advances and Future Prospects

Nano Select, Volume 7, Issue 6, June 2026.
The introduction covers the background and significance of conjunctivitis. It continues with a review of etiology, epidemiology, and clinical manifestations. Diagnostic methods are described, followed by discussions on pathophysiology and classification. Current treatment strategies, preventive measures, and therapeutic challenges are analyzed.
Xia Linkang, Marwan Abdelmahmoud Abdelkarim Maki, Saad Tayyab, Sachin Thakur, Pankaj Kumar, Ritu Karwasra, Mahesh Harihar Behare, Nitin Sharma, Wan Hamirul Bahrin Wan Kamal, Oganeswary Kobi, Kushagra Khanna, Mogana Rajagopal   +11 more
wiley   +1 more source

Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors

Beilstein Journal of Nanotechnology, 2015
The use of data mining techniques in the field of nanomedicine has been very limited. In this paper we demonstrate that data mining techniques can be used for the development of predictive models of the cytotoxicity of poly(amido amine) (PAMAM ...
David E. Jones, Hamidreza Ghandehari, Julio C. Facelli   +2 more
doaj   +1 more source

PAMAM-dendrimer Enhanced Antibacterial Effect of Vancomycin Hydrochloride Against Gram-Negative Bacteria

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Purpose: The antibacterial activity of some antibiotics is specific to either Gram-positive or Gram-negative bacteria.  There are different mechanisms behind such insensitivities like inability of antibiotics to permeate through some bacterial membranes,
Azadeh Serri, Arash Mahboubi, Afshin Zarghi, Hamid Reza Moghimi   +3 more
doaj   +1 more source

Gold Nanoparticle–Trastuzumab Conjugates for HER2‐Positive Breast Cancer Treatment: Developments in Radionuclide Therapy, Multimodal Imaging, and Combination Strategies

Nano Select, Volume 7, Issue 6, June 2026.
ABSTRACT This work comprehensively examines recent advances in the treatment of human epidermal growth factor receptor 2 (HER2)‐positive breast cancer using trastuzumab‐conjugated gold nanoparticles (AuNPs). By analyzing several pivotal studies, it explores how these nanoplatforms enhance therapeutic specificity and efficacy while minimizing systemic ...
Tara Tarzi, Zhina Pazhouhesh, Danial Heyrati, Amir Mohammad Ghanbari Zarmehri, Ali Es‐haghi, Mohammad Ehsan Taghavizadeh Yazdi   +5 more
wiley   +1 more source

Fluorinated Amphiphilic Dendrimer to Improve PET Imaging of Cancer

Small, Volume 22, Issue 35, 23 June 2026.
Fluorination of a self‐assembling dendrimer nanosystem reduced liver retention, accelerated renal clearance and improved biodistribution, ultimately enhancing tumor uptake and enabling more sensitive tumor detection by positron emission tomography (PET).
Béatrice Louis, Tom Roussel, Twiany Cruz‐Dubois, Ling Ding, Zhenbin Lyu, Erik Laurini, Jessica Ou, Laure Balasse, Adrien Chabert, Vincent Nail, Ahlem Bouhlel, Françoise Dignat‐George, Florence Gattacceca, Sabrina Pricl, Benjamin Guillet, Ling Peng, Philippe Garrigue   +16 more
wiley   +1 more source

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells.

Journal of Toxicological Sciences, 2016
Polyamidoamine (PAMAM) dendrimers have potential for biological applications as delivery systems for genes, drugs, and imaging agents into the brain, but their developmental neurotoxicity remains unknown.
Yang Zeng, Y. Kurokawa, Tin-Tin Win-Shwe, Qin Zeng, S. Hirano, Zhenya Zhang, H. Sone   +6 more
semanticscholar   +1 more source

The Structure of PAMAM DAB-dendr(NH2)4 – the First Crystal Structure of a PAMAM-Dendrimer

, 2020
The first crystal structure of an amino terminated PAMAM-dendrimer (DABdendr(NH2)4) is reported. The structure features a compact dendrimer conformation without voids, held together by intermolecular hydrogen bonds between ...
Joern, Christensen, Jesper, Bendix
core   +1 more source

PAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding

Pharmaceutics
Background/Objectives: Current promising treatments for many diseases are based on the use of therapeutic nucleic acids, including DNA. However, the list of nanocarriers is limited due to their low biocompatibility, high cost, and toxicity. The design of
Olga Mostovaya, Igor Shiabiev, Daniil Ovchinnikov, Dmitry Pysin, Timur Mukhametzyanov, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Arthur Khannanov, Marianna Kutyreva, Mingwu Shen, Xiangyang Shi, Pavel Padnya, Ivan Stoikov   +13 more
doaj   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, Volume 293, Issue 11, Page 3187-3210, June 2026.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source