Results 61 to 70 of about 54,619 (251)

Structure of DNA-Functionalized Dendrimer Nanoparticles

, 2012
Atomistic molecular dynamics simulations have been carried out to reveal the characteristic features of ethylenediamine (EDA) cored protonated poly amido amine (PAMAM) dendrimers of generation 3 (G3) and 4 (G4) that are functionalized with single ...
Aldaye, Alivisatos, Bao, Berendsen, Blab, Bliznyuk, Carbone, Choi, Choi, Condon, Dai, Dai, Duan, Esfand, Feldkamp, Gurtovenko, Hainfeld, Hill, Hsu, Huang, Hurst, Jain, Jain, Jorgensen, Kalogianni, Karatasos, Ke, Klos, Lara, Largo, Lee, Lee, Lee, Lee, Li, Liu, Lu, Lyulin, Macfarlane, Maiti, Maiti, Maiti, Maiti, Maiti, Mattaparthi Venkata Satish Kumar, Mayo, Mijovic, Mirkin, Mizutani, Nandy, Niemeyer, Niemeyer, Nykypanchuk, Paciotti, Padovan-Merhar, Park, Park, Pearlman, Prabal K Maiti, Rosi, Rosi, Ryckaert, Seeman, Sosinsky, Starr, Stechemesser, Storhoff, Suek, Sun, Thankappan, Tomalia, Tomalia, Tomalia, Tomalia, Tomalia, Uppuluri, Vasumathi, Xiong, Zhao   +78 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

Novel Aldehyde-Terminated Dendrimers; Synthesis and Cytotoxicity Assay

BioImpacts, 2012
Introduction: Polyamidoamine (PAMAM) dendrimers are a unique family of dendritic polymers with numerous pharmaceutical and biomedical applications. One major problem with these polymers is their cytotoxicity.
Mohammad-Reza Rashidi, Yadollah Omidi, Saeed Ghasemi, Soodabeh Davaran, Simin Sharifi, Aliasghar Hamidi   +5 more
doaj   +1 more source

Charge-induced conformational changes of dendrimers

, 2008
We study the effect of chargeable monomers on the conformation of dendrimers of low generation by computer simulations, employing bare Coulomb interactions. The presence of the latter leads to an increase in size of the dendrimer due to a combined effect
Allen M. P., Antoni P., Ballauff M., Buhleier G. E., Evans H. M., Frenkel D., Galperin D. E., Grest G. S., Guipponi G., Gurtovenko A. A., Götze I. O., Götze I. O., Jusufi A., Konieczny M., Korn G. A., Likos. C. N., Lyulin S. V., Majtyka M., Mei Y., Meier-Kroll A. A., Nisato G., Pötschke D., Pötschke D., Rathgeber S., Rädler J. O., Verma I. M., Welch P., Wittemann A., Zook T. C.   +28 more
core   +1 more source

Structure of poly(propyl ether imine) (PETIM) dendrimer from fully atomistic molecular Dynamics Simulation and by Small Angle X-ray scattering [PDF]

, 2006
We study the structure of carboxylic acid terminated neutral poly (propyl ether imine) (PETIM) dendrimer from generation 1 through 6 (G1-G6) in a good solvent (water) by fully atomistic molecular dynamics (MD) simulations.
A. K. Sood, Adronov A., Chandan Jana, G. Jayamurugan, Hearshaw M. A., N. Jayaraman, Prabal K. Maiti, Rajesh Ganapathy, Rapaport D. C.   +8 more
core   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Slow-Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer. [PDF]

, 2018
The plant viral nanoparticle cowpea mosaic virus (CPMV) is shown to be an effective immunotherapy for ovarian cancer when administered as in situ vaccine weekly, directly into the intraperitoneal (IP) space in mice with disseminated tumors.
Aguirre, Albertazzi, Bysell, Callahan, Cho, Cho, Conejo-Garcia, Corrales, Czapar, Dobrovolskaia, Emoto, Fransen, Hammerich, Jayson, Kostiainen, Kostiainen, LeBlond, Lin, Lizotte, Lomonossoff, Mikkilä, Mukherjee, Pandita, Pardoll, Pierce, Prokop, Singh, Smet, Stefano, Sun, Susman, Umeki, Veliz, Wallat, Wang, Wen, Wen, Wen, Winograd, Wright, Xu, Yoon   +41 more
core   +2 more sources

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Dendrimers: Synthesis, Encapsulation Applications and Specific Interaction with the Stratum Corneum—A Review

Macromol, 2023
Dendrimers are increasingly being studied in the context of encapsulation. Many potential applications of dendrimers are based on their properties. They are used in drug delivery systems, cosmetics, food and chemistry.
Katia Bacha, Catherine Chemotti, Jean-Pierre Mbakidi, Magali Deleu, Sandrine Bouquillon   +4 more
doaj   +1 more source