Results 1 to 10 of about 825,352 (312)

Anti-Mouse CD83 Monoclonal Antibody Targeting Mature Dendritic Cells Provides Protection Against Collagen Induced Arthritis

Frontiers in Immunology, 2022
Antibodies targeting the activation marker CD83 can achieve immune suppression by targeting antigen-presenting mature dendritic cells (DC). This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment in mice and tested its ...
Pablo A. Silveira, Pablo A. Silveira, Fiona Kupresanin, Adelina Romano, Wei-Hsun Hsu, Wei-Hsun Hsu, Tsun-Ho Lo, Xinsheng Ju, Xinsheng Ju, Hsiao-Ting Chen, Hsiao-Ting Chen, Helen Roberts, Daniel G. Baker, Georgina J. Clark, Georgina J. Clark, Georgina J. Clark   +15 more
doaj   +1 more source

Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models

Frontiers in Immunology, 2023
Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that can increase DC abundance in the tumor when administered therapeutically.
Emile J. Clappaert, Emile J. Clappaert, Emile J. Clappaert, Daliya Kancheva, Daliya Kancheva, Daliya Kancheva, Jan Brughmans, Jan Brughmans, Ayla Debraekeleer, Ayla Debraekeleer, Pauline M. R. Bardet, Pauline M. R. Bardet, Yvon Elkrim, Yvon Elkrim, Dagmar Lacroix, Dagmar Lacroix, Maida Živalj, Maida Živalj, Ahmed E.I. Hamouda, Ahmed E.I. Hamouda, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Sofie Deschoemaeker, Sofie Deschoemaeker, Damya Laoui, Damya Laoui   +25 more
doaj   +1 more source

Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody

Clinical & Translational Immunology, 2020
Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma.
Ziduo Li, Edward Abadir, Kenneth Lee, Candice Clarke, Christian E Bryant, Wendy Cooper, Geoffrey Pietersz, James Favaloro, Pablo A Silveira, Derek NJ Hart, Xinsheng Ju, Georgina J Clark   +11 more
doaj   +1 more source

Computational convergence of the path integral for real dendritic morphologies [PDF]

, 2012
Neurons are characterised by a morphological structure unique amongst biological cells, the core of which is the dendritic tree. The vast number of dendritic geometries, combined with heterogeneous properties of the cell membrane, continue to challenge ...
Brand, Samuel, Caudron, Quentin, Donnelly, Simon R., Timofeeva, Yulia   +3 more
core   +2 more sources

Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy

Pharmaceutics, 2020
The onset of checkpoint inhibition revolutionized the treatment of cancer. However, studies from the last decade suggested that the sole enhancement of T cell functionality might not suffice to fight malignancies in all individuals. Dendritic cells (DCs)
Lukas Amon, Lukas Hatscher, Lukas Heger, Diana Dudziak, Christian H. K. Lehmann   +4 more
doaj   +1 more source

The role of ongoing dendritic oscillations in single-neuron dynamics [PDF]

, 2009
The dendritic tree contributes significantly to the elementary computations a neuron performs while converting its synaptic inputs into action potential output.
A Alonso, A Alonso, A Kamondi, A Lörincz, A Mauro, Boris S. Gutkin, C Koch, C Morris, CA Chapman, CT Dickson, D Johnston, D Placantonakis, E Fransén, E Izhikevich, G Stuart, GB Ermentrout, GS Medvedev, HC Pape, J O'Keefe, J Rinzel, JA Goldberg, JC Magee, JT Davie, Karl J. Friston, LE Moore, LM Giocomo, LW Leung, M London, M Rudolph, M Sanhueza, M Yoshida, ME Hasselmo, Michiel W. H. Remme, Máté Lengyel, N Burgess, N Kopell, NT Carnevale, P Poirazi, PC Bressloff, RF Galán, RR Llinás, SM Crook, W Rall, Y Gutfreund, Z Huhn   +44 more
core   +4 more sources

HLA-DR+ Immature Cells Exhibit Reduced Antigen-Presenting Cell Function But Respond to CD40 Stimulation

Neoplasia: An International Journal for Oncology Research, 2005
Dendritic cells (DC) have been implicated in the defective function of the immune system during cancer progression. We have demonstrated that patients with cancer have fewer myeloid (CD11c+) and plasmacytoid (CD123hi) DC and a concurrent accumulation of ...
Alberto Pinzon-Charry, Tammy Maxwell, Sandro Prato, Colin Furnival, Chris Schmidt, José Alejandro López   +5 more
doaj   +1 more source

The dendritic cell niche in chronic obstructive pulmonary disease. [PDF]

, 2012
The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD).
Haczku, Angela
core   +3 more sources

CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential

Frontiers in Immunology, 2019
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic
Ziduo Li, Ziduo Li, Xinsheng Ju, Xinsheng Ju, Pablo A. Silveira, Pablo A. Silveira, Edward Abadir, Edward Abadir, Wei-Hsun Hsu, Wei-Hsun Hsu, Derek N. J. Hart, Derek N. J. Hart, Georgina J. Clark, Georgina J. Clark   +13 more
doaj   +1 more source

Dendritic cells in plasmodium infection [PDF]

, 2008
Infection with Plasmodium parasites (malaria) contributes greatly to morbidity and mortality in affected areas. Interaction of the protozoan with the immune system has a critical role in the pathogenesis of the disease, but may also hold a key to ...
Alonso, Bejon, Britta C Urban, Bruna-Romero, deWalick, Greenwood, Park, Patel, Perry, Pichyangkul, Pouniotis, Skorokhod, Stephen M Todryk, Todryk, Wong, Wykes   +15 more
core   +2 more sources