Results 1 to 10 of about 778,422 (341)

Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration [PDF]

Journal of Immunology Research
Dendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments.
Min-Seon Song, Ji-Hee Nam, Kyung-Eun Noh, Dae-Seog Lim   +3 more
doaj   +2 more sources

Anti-Mouse CD83 Monoclonal Antibody Targeting Mature Dendritic Cells Provides Protection Against Collagen Induced Arthritis

Frontiers in Immunology, 2022
Antibodies targeting the activation marker CD83 can achieve immune suppression by targeting antigen-presenting mature dendritic cells (DC). This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment in mice and tested its ...
Pablo A. Silveira, Pablo A. Silveira, Fiona Kupresanin, Adelina Romano, Wei-Hsun Hsu, Wei-Hsun Hsu, Tsun-Ho Lo, Xinsheng Ju, Xinsheng Ju, Hsiao-Ting Chen, Hsiao-Ting Chen, Helen Roberts, Daniel G. Baker, Georgina J. Clark, Georgina J. Clark, Georgina J. Clark   +15 more
doaj   +1 more source

Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models

Frontiers in Immunology, 2023
Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that can increase DC abundance in the tumor when administered therapeutically.
Emile J. Clappaert, Emile J. Clappaert, Emile J. Clappaert, Daliya Kancheva, Daliya Kancheva, Daliya Kancheva, Jan Brughmans, Jan Brughmans, Ayla Debraekeleer, Ayla Debraekeleer, Pauline M. R. Bardet, Pauline M. R. Bardet, Yvon Elkrim, Yvon Elkrim, Dagmar Lacroix, Dagmar Lacroix, Maida Živalj, Maida Živalj, Ahmed E.I. Hamouda, Ahmed E.I. Hamouda, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Sofie Deschoemaeker, Sofie Deschoemaeker, Damya Laoui, Damya Laoui   +25 more
doaj   +1 more source

Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody

Clinical & Translational Immunology, 2020
Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma.
Ziduo Li, Edward Abadir, Kenneth Lee, Candice Clarke, Christian E Bryant, Wendy Cooper, Geoffrey Pietersz, James Favaloro, Pablo A Silveira, Derek NJ Hart, Xinsheng Ju, Georgina J Clark   +11 more
doaj   +1 more source

Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy

Pharmaceutics, 2020
The onset of checkpoint inhibition revolutionized the treatment of cancer. However, studies from the last decade suggested that the sole enhancement of T cell functionality might not suffice to fight malignancies in all individuals. Dendritic cells (DCs)
Lukas Amon, Lukas Hatscher, Lukas Heger, Diana Dudziak, Christian H. K. Lehmann   +4 more
doaj   +1 more source

The role of ongoing dendritic oscillations in single-neuron dynamics [PDF]

, 2009
The dendritic tree contributes significantly to the elementary computations a neuron performs while converting its synaptic inputs into action potential output.
A Alonso, A Alonso, A Kamondi, A Lörincz, A Mauro, Boris S. Gutkin, C Koch, C Morris, CA Chapman, CT Dickson, D Johnston, D Placantonakis, E Fransén, E Izhikevich, G Stuart, GB Ermentrout, GS Medvedev, HC Pape, J O'Keefe, J Rinzel, JA Goldberg, JC Magee, JT Davie, Karl J. Friston, LE Moore, LM Giocomo, LW Leung, M London, M Rudolph, M Sanhueza, M Yoshida, ME Hasselmo, Michiel W. H. Remme, Máté Lengyel, N Burgess, N Kopell, NT Carnevale, P Poirazi, PC Bressloff, RF Galán, RR Llinás, SM Crook, W Rall, Y Gutfreund, Z Huhn   +44 more
core   +4 more sources

Computational convergence of the path integral for real dendritic morphologies [PDF]

, 2012
Neurons are characterised by a morphological structure unique amongst biological cells, the core of which is the dendritic tree. The vast number of dendritic geometries, combined with heterogeneous properties of the cell membrane, continue to challenge ...
Brand, Samuel, Caudron, Quentin, Donnelly, Simon R., Timofeeva, Yulia   +3 more
core   +2 more sources

Moving on From Sipuleucel-T: New Dendritic Cell Vaccine Strategies for Prostate Cancer

Frontiers in Immunology, 2021
Tumors evade the immune system though a myriad of mechanisms. Using checkpoint inhibitors to help reprime T cells to recognize tumor has had great success in malignancies including melanoma, lung, and renal cell carcinoma.
Sarah I. M. Sutherland, Sarah I. M. Sutherland, Sarah I. M. Sutherland, Sarah I. M. Sutherland, Xinsheng Ju, Xinsheng Ju, L. G. Horvath, L. G. Horvath, L. G. Horvath, Georgina J. Clark, Georgina J. Clark   +10 more
doaj   +1 more source

The dendritic cell niche in chronic obstructive pulmonary disease. [PDF]

, 2012
The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD).
Haczku, Angela
core   +3 more sources

HLA-DR+ Immature Cells Exhibit Reduced Antigen-Presenting Cell Function But Respond to CD40 Stimulation

Neoplasia: An International Journal for Oncology Research, 2005
Dendritic cells (DC) have been implicated in the defective function of the immune system during cancer progression. We have demonstrated that patients with cancer have fewer myeloid (CD11c+) and plasmacytoid (CD123hi) DC and a concurrent accumulation of ...
Alberto Pinzon-Charry, Tammy Maxwell, Sandro Prato, Colin Furnival, Chris Schmidt, José Alejandro López   +5 more
doaj   +1 more source