Results 21 to 30 of about 12,319,760 (359)

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

Cell, 2019
Summary Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to their unique ability to initiate T cell responses and direct their differentiation into effector lineages.
Chrysothemis C. Brown, Herman Gudjonson, Yuri Pritykin, Deeksha Deep, Vincent-Philippe Lavallée, A. Mendoza, R. Fromme, L. Mazutis, C. Ariyan, C. Leslie, D. Pe’er, A. Rudensky   +11 more
semanticscholar   +1 more source

Tumor-infiltrating dendritic cell states are conserved across solid human cancers

Journal of Experimental Medicine, 2020
Gerhard et al. reveal the conservation of human tumor-infiltrating dendritic cell states via meta-analysis of scRNA-seq datasets. They further explore dendritic cell state conservation in mice and the origins, behavior, and functions of these cells.
Genevieve M. Gerhard, R. Bill, Marius Messemaker, Allon M. Klein, M. Pittet   +4 more
semanticscholar   +1 more source

Tetanic Stimulation Leads to Increased Accumulation of Ca^(2+)/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons [PDF]

, 1999
mRNA for the ɑ-subunit of CaMKII is abundant in dendrites of neurons in the forebrain (Steward, 1997). Here we show that tetanic stimulation of the Schaffer collateral pathway causes an increase in the concentration of ɑ-CaMKII in the dendrites of ...
Kennedy, Mary B., Kreiman, Gabriel, Ouyang, Yannan, Rosenstein, Alan, Schuman, Erin M.   +4 more
core   +1 more source

CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma

Haematologica, 2018
Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better tumor-specific target therapy in Hodgkin lymphoma patients with refractory or relapsed disease ...
Ziduo Li, Xinsheng Ju, Kenneth Lee, Candice Clarke, Jennifer L. Hsu, Edward Abadir, Christian E. Bryant, Suzanne Pears, Neroli Sunderland, Scott Heffernan, Annemarie Hennessy, Tsun-Ho Lo, Geoffrey A. Pietersz, Fiona Kupresanin, Phillip D. Fromm, Pablo A. Silveira, Con Tsonis, Wendy A. Cooper, Ilona Cunningham, Christina Brown, Georgina J. Clark, Derek N.J. Hart   +21 more
doaj   +1 more source

Information Fusion for Anomaly Detection with the Dendritic Cell Algorithm [PDF]

, 2010
Dendritic cells are antigen presenting cells that provide a vital link between the innate and adaptive immune system, providing the initial detection of pathogenic invaders.
Aickelin, Uwe, Greensmith, Julie, Tedesco, Gianni   +2 more
core   +3 more sources

On the Other Side: Manipulating the Immune Checkpoint Landscape of Dendritic Cells to Enhance Cancer Immunotherapy

Frontiers in Oncology, 2019
Monoclonal antibodies targeting co-inhibitory immune checkpoint molecules have been successful in clinical trials of both solid and hematological malignancies as acknowledged by the 2018 Nobel Prize in Medicine, however improving clinical response rates ...
Benjamin Y. Kong, Benjamin Y. Kong, Benjamin Y. Kong, Holly Bolton, Holly Bolton, Julius W. Kim, Julius W. Kim, Pablo A. Silveira, Pablo A. Silveira, Phillip D. Fromm, Phillip D. Fromm, Georgina J. Clark, Georgina J. Clark   +12 more
doaj   +1 more source

IOX1 impedes host inflammation in imiquimod-triggered psoriasis

Heliyon, 2021
Psoriasis is a chronic autoimmune disease with an unknown etiology and highly limited treatment strategies. The drugs currently used in the treatment of psoriasis are rarely recommended for long-term use owing to the serious side effects.
Joo Eun Shin, Su Jin Lee, Amal Gharbi, In Duk Jung, Yeong Min Park   +4 more
doaj   +1 more source

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Nature Communications, 2019
N6-methyladenosine (m6A) modification plays important roles in various cellular responses by regulating mRNA biology. However, how m6A modification is involved in innate immunity via affecting the translation of immune transcripts remains to be further ...
Huamin Wang, Xiang Hu, Mingyan Huang, Juan Liu, Yan Gu, Lijia Ma, Qi Zhou, Xuetao Cao   +7 more
semanticscholar   +1 more source

Branching dendrites with resonant membrane: a “sum-over-trips” approach [PDF]

, 2007
Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons.
A Mauro, A Ooyen van, A Scott, AJ Hudspeth, B Hutcheon, B Hutcheon, BJ Cao, C Koch, C Koch, C. -M. Svensson, C. M. Colbert, D Johnson, EG Butz, G. J. Lord, HC Pape, HC Tuckwell, I Segev, JC Magee, JD Evans, JD Evans, K. Josić, LF Abbott, LF Abbott, M Häusser, M London, M London, M Migliore, MHP Kole, NT Carnevale, S. Coombes, S. J. Cox, SJ Cox, SJ Cox, X Li, Y Timofeeva, Y Timofeeva, Y. Timofeeva, ZF Mainen   +37 more
core   +3 more sources

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
A Kihara, A Kissenpfennig, A Kumar, A Martino, A Olivera, A Weigert, AD Christensen, Burkhard Kleuser, C Ocana-Morgner, C Ruedl, CC Norbury, CL Bennett, CL Bennett, DH Kaplan, DH Kaplan, E Guaguere, ES Trombetta, EY Seo, F Sparber, G Gollmann, G Schuhmachers, H Hackstein, H Liu, Heinfried H. Radeke, HH Radeke, I Reines, J Chun, Jagadeesh Bayry, JH Hong, K Kabashima, K Sarkar, K Takabe, Katrin Schaper, L Japtok, L Rose, L Ruwisch, LS Bursch, Lukasz Japtok, M Hara-Chikuma, M Matloubian, M Schröder, M Schuppel, MB Lutz, MC Kerr, ML Allende, ML Allende, N Romani, P Mitra, P Monti, R van de Ven, RH Kim, RM Steinman, S Spiegel, S Sullivan, S Xu, Se Kyoo Jeong, SH Wood, SP Zahner, T Hla, T Kitajima, T Walzer, V Brinkmann, W Baumer, W Baumer, W Baumer, Wolfgang Bäumer, Y Maeda, Y Yanagawa, YY Lan   +68 more
core   +5 more sources