Results 41 to 50 of about 12,319,760 (359)

Tagraxofusp in Blastic Plasmacytoid Dendritic‐Cell Neoplasm

New England Journal of Medicine, 2019
Background Blastic plasmacytoid dendritic‐cell neoplasm (BPDCN) is an aggressive hematologic cancer that is caused by transformed plasmacytoid dendritic cells that overexpress interleukin‐3 receptor subunit alpha (IL3RA or CD123). Tagraxofusp (SL‐401) is
N. Pemmaraju, A. Lane, K. Sweet, A. Stein, S. Vasu, W. Blum, D. Rizzieri, E. Wang, M. Duvic, M. Sloan, S. Spence, S. Shemesh, C. Brooks, J. Balser, I. Bergstein, J. Lancet, H. Kantarjian, M. Konopleva   +17 more
semanticscholar   +1 more source

Why Neurons Have Thousands of Synapses, A Theory of Sequence Memory in Neocortex [PDF]

, 2015
Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables.
Ahmad, Subutai, Hawkins, Jeff
core   +3 more sources

Immunometabolism governs dendritic cell and macrophage function

Journal of Experimental Medicine, 2016
In this review, O’Neill and Pearce discuss recent intriguing findings on metabolic changes regulating the function of macrophages and dendritic cells.
L. O’Neill, E. Pearce
semanticscholar   +1 more source

SnapShot: Dendritic Cells

Cell, 2011
[No abstract available]
Idoyaga, Juliana, Steinman, Ralph M.
openaire   +2 more sources

Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1/Sle2/Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen

Journal of Immunology Research, 2018
Type I interferons (IFN) are pathogenic in systemic lupus erythematosus (SLE) and were proposed to control the immunometabolism of dendritic cells (DCs).
Michael H. Lee, Marita Chakhtoura, Uma Sriram, Roberto Caricchio, Stefania Gallucci   +4 more
doaj   +1 more source

Engineering dendritic cell vaccines to improve cancer immunotherapy

Nature Communications, 2019
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy.
Caleb R. Perez, Michele De Palma
semanticscholar   +1 more source

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity [PDF]

, 2017
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote ...
Brossard, Natalie, Carmona, Carlos, Dergan Dylon, Leonardo Sebastian, Freire, Teresa, Noya, Verónica, Rabinovich, Gabriel Adrián, Rodríguez, Ernesto   +6 more
core   +1 more source

Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies

Human Vaccines & Immunotherapeutics, 2018
Immune responses in human populations are highly variable, with this variability presenting challenges for vaccine design. As such a better understanding of the factors that determine this variability will help in the development of precision vaccination
Darragh Duffy
doaj   +1 more source

Deconvolution of the Response to Bacillus Calmette–Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity

Frontiers in Immunology, 2017
Bacillus Calmette–Guérin (BCG) is used as a vaccine and diagnostic test for tuberculosis, as well as immunotherapy in the treatment of bladder cancer. While clinically useful, the response to mycobacterial stimulation is complex and the induced protein ...
Aurélie Bisiaux, Aurélie Bisiaux, Jeremy Boussier, Jeremy Boussier, Jeremy Boussier, Darragh Duffy, Darragh Duffy, Lluis Quintana-Murci, Lluis Quintana-Murci, Magnus Fontes, Matthew L. Albert, Matthew L. Albert, Matthew L. Albert, The Milieu Intérieur Consortium   +13 more
doaj   +1 more source

CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion

Frontiers in Immunology, 2018
Dendritic cells (DCs) are major players for the induction of immune responses. Apart from plasmacytoid DCs (pDCs), human DCs can be categorized into two types of conventional DCs: CD141+ DCs (cDC1) and CD1c+ DCs (cDC2).
Lukas Heger, Silke Balk, Jennifer J. Lühr, Gordon F. Heidkamp, Christian H. K. Lehmann, Lukas Hatscher, Ariawan Purbojo, Arndt Hartmann, Fayna Garcia-Martin, Shin-Ichiro Nishimura, Robert Cesnjevar, Falk Nimmerjahn, Diana Dudziak   +12 more
doaj   +1 more source