Results 41 to 50 of about 778,422 (341)

Using the Man9(GlcNAc)2 – DC-SIGN pairing to probe specificity in photochemical immobilization [PDF]

, 2010
We demonstrate the expected preference of an immobilised oligosaccharide Man(9)(GlcNAc)(2) upon a 96-well photochemical array, for its known receptor, the cell-surface lectin Dendritic Cell-Specific ICAM3 Grabbing Nonintegrin (DC-SIGN) when compared to ...
Clark, Andrew J., Dilly, Suzanne J., Marsh, Andrew, Mitchell, Daniel A., Taylor, Paul C.   +4 more
core   +1 more source

A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo [PDF]

, 2018
Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity.
Baz Morelli, Adriana, Benson, Robert A., Brewer, James M., Garside, Paul, Hayes, Alan J., Maraskovsky, Eugene, Meehan, Gavin R., Scales, Hannah E., Tomura, Michio, Walters, Anne, Watson, Emma   +10 more
core   +3 more sources

Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies

Human Vaccines & Immunotherapeutics, 2018
Immune responses in human populations are highly variable, with this variability presenting challenges for vaccine design. As such a better understanding of the factors that determine this variability will help in the development of precision vaccination
Darragh Duffy
doaj   +1 more source

Human Dendritic Cell Subset Isolation by Magnetic Bead Sorting: A Protocol to Efficiently Obtain Pure Populations

Bio-Protocol, 2023
Dendritic cells have been investigated for cell-based immunotherapy for various applications. The low abundance of dendritic cells in blood hampers their clinical application, resulting in the use of monocyte-derived dendritic cells as an alternative ...
Georgina Flórez-Grau, Jorge Cuenca Escalona, Helena Lacasta-Mambo, Daphne Roelofs, Johanna Bödder, Ruben Beuk, Gerty Schreibelt, I Jolanda de Vries   +7 more
doaj   +1 more source

Targeting Human Dendritic Cells with Lewis X Modified Liposomes [PDF]

, 2010
In this short report, we demonstrate that liposomes bearing the Lewis X trisaccharide on the surface (“Awesosomes”) efficiently target human dendritic cells.
Lucie Kalvodova, Yongmin Zhang
core   +2 more sources

Dendritic Cells—Ontogeny—

Allergology International, 2007
Dendritic cells (DC) play key rolls in various aspects of immunity. The functions of DC depend on the subsets as well as their location or activation status. Understanding developmental lineages, precursors and inducing factors for various DC subsets would help their clinical application, but despite extensive efforts, the precise ontogeny of various ...
Masutaka Furue, Satoshi Takeuchi
openaire   +4 more sources

Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1/Sle2/Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen

Journal of Immunology Research, 2018
Type I interferons (IFN) are pathogenic in systemic lupus erythematosus (SLE) and were proposed to control the immunometabolism of dendritic cells (DCs).
Michael H. Lee, Marita Chakhtoura, Uma Sriram, Roberto Caricchio, Stefania Gallucci   +4 more
doaj   +1 more source

Deconvolution of the Response to Bacillus Calmette–Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity

Frontiers in Immunology, 2017
Bacillus Calmette–Guérin (BCG) is used as a vaccine and diagnostic test for tuberculosis, as well as immunotherapy in the treatment of bladder cancer. While clinically useful, the response to mycobacterial stimulation is complex and the induced protein ...
Aurélie Bisiaux, Aurélie Bisiaux, Jeremy Boussier, Jeremy Boussier, Jeremy Boussier, Darragh Duffy, Darragh Duffy, Lluis Quintana-Murci, Lluis Quintana-Murci, Magnus Fontes, Matthew L. Albert, Matthew L. Albert, Matthew L. Albert, The Milieu Intérieur Consortium   +13 more
doaj   +1 more source

Long Overall Survival After Dendritic Cell Vaccination in Metastatic Uveal Melanoma Patients [PDF]

, 2014
Purpose: To assess the safety and efficacy of dendritic cell vaccination in metastatic uveal melanoma. Design: Interventional case series. Methods: We analyzed 14 patients with metastatic uveal melanoma treated with dendritic cell vaccination.
Aarntzen, E.H.J.G. (Erik), Bol, K.F. (Kalijn), Coulie, P.G. (Pierre), Figdor, C.G. (Carl), Keunen, J.E.E. (Jan), Klein, J.E.M.M. (Annelies) de, Mensink, H.W. (Hanneke), Paridaens, A.D.A. (Dion), Punt, C.J.A. (Cornelis), Schreibelt, G. (Gerty), Vries, I.J.M. (Jolanda) de   +10 more
core   +1 more source

CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion

Frontiers in Immunology, 2018
Dendritic cells (DCs) are major players for the induction of immune responses. Apart from plasmacytoid DCs (pDCs), human DCs can be categorized into two types of conventional DCs: CD141+ DCs (cDC1) and CD1c+ DCs (cDC2).
Lukas Heger, Silke Balk, Jennifer J. Lühr, Gordon F. Heidkamp, Christian H. K. Lehmann, Lukas Hatscher, Ariawan Purbojo, Arndt Hartmann, Fayna Garcia-Martin, Shin-Ichiro Nishimura, Robert Cesnjevar, Falk Nimmerjahn, Diana Dudziak   +12 more
doaj   +1 more source