Results 41 to 50 of about 825,352 (312)

IOX1 activity as sepsis therapy and an antibiotic against multidrug-resistant bacteria

Scientific Reports, 2021
Sepsis is caused by organ dysfunction initiated by an unrestrained host immune response to infection. The emergence of antibiotic-resistant bacteria has rapidly increased in the last decades and has stimulated a firm research platform to combat ...
Su Jin Lee, Jueng Soo You, Amal Gharbi, Yong Joo Kim, Mi Suk Lee, Dong Hwan Kim, Keun Woo Lee, In Duk Jung, Yeong Min Park   +8 more
doaj   +1 more source

Why Neurons Have Thousands of Synapses, A Theory of Sequence Memory in Neocortex [PDF]

, 2015
Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables.
Ahmad, Subutai, Hawkins, Jeff
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Triggers of Autoimmunity: The Role of Bacterial Infections in the Extracellular Exposure of Lupus Nuclear Autoantigens

Frontiers in Immunology, 2019
Infections are considered important environmental triggers of autoimmunity and can contribute to autoimmune disease onset and severity. Nucleic acids and the complexes that they form with proteins—including chromatin and ribonucleoproteins—are the main ...
Connie C. Qiu, Roberto Caricchio, Stefania Gallucci   +2 more
doaj   +1 more source

Differential and Temporal Immunomodulation of alpha4 Integrins on CD4+ Memory Cells by Bordetella pertussis and Bordetella parapertussis [PDF]

, 2012
Pertussis, caused by Bordetella pertussis (B. pertussis), is reemerging worldwide due to vaccine inefficacy. The hallmarks of infection are extreme lymphocytosis and delayed recovery, which are partially associated with pertussis toxin.
Ravindra, Dipti
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

General features of the retinal connectome determine the computation of motion anticipation [PDF]

, 2015
Motion anticipation allows the visual system to compensate for the slow speed of phototransduction so that a moving object can be accurately located.
Asari, Baylor, Berry, Bischofberger, Blitz, Bollmann, Bonin, Borst, Branco, Branco, Briggman, Bölinger, Cafaro, Calkins, Calkins, Chen, Demb, Dreosti, Esposti, Freed, Gleeson, Gollisch, Goodale, Gouras, Haider, Hao, Hausselt, Haverkamp, Helmstaedter, Hines, Hitchcock, HUBEL, Isaacson, Jakobs, Jarsky, Johnston, Koch, Koizumi, Kolb, Kolb, Kolb, Koontz, Kuzmiski, Lee, Leonardo, Levick, Liu, London, Lukasiewicz, MacNeil, Magee, Malpeli, Manookin, Marshak, Marshak, Masland, Miller, Münch, Nikolaev, Odermatt, Oesch, Olveczky, Owczarzak, Pouille, Quiroga, RALL, Rieke, Roska, Schachter, Schwartz, Schwartz, Sivyer, Smith, Talbot, Tanaka, Taylor, Trenholm, Weber, West, Xu, Yonehara, Zhu   +81 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Quantification of dendritic cell subsets in human thymus tissues of various ages

Immunity & Ageing, 2021
Background Dendritic cells (DCs) in the thymus are involved in central tolerance formation, but they also have other functions in the thymus, such as pathogen recognition. The density changes of human thymic DCs have been hardly investigated.
Yan Li, Pei Chen, Hao Huang, Huiyu Feng, Hao Ran, Weibin Liu   +5 more
doaj   +1 more source