Results 51 to 60 of about 778,422 (341)

IOX1 activity as sepsis therapy and an antibiotic against multidrug-resistant bacteria

Scientific Reports, 2021
Sepsis is caused by organ dysfunction initiated by an unrestrained host immune response to infection. The emergence of antibiotic-resistant bacteria has rapidly increased in the last decades and has stimulated a firm research platform to combat ...
Su Jin Lee, Jueng Soo You, Amal Gharbi, Yong Joo Kim, Mi Suk Lee, Dong Hwan Kim, Keun Woo Lee, In Duk Jung, Yeong Min Park   +8 more
doaj   +1 more source

Dendritic Cells in Atherosclerosis [PDF]

Current Pharmaceutical Design, 2013
It is recognized that the development of atherosclerosis involves many elements of an inflammatory process, involving components of both the innate and adaptive immune systems. The presence and roles of macrophages and T-cells in atherogenesis are well-established.
Wendy Jessup, Siân P. Cartland
openaire   +5 more sources

Microchimerism, dendritic cell progenitors and transplantation tolerance [PDF]

, 1995
The recent discovery of multilineage donor leukocyte microchimerism in allograft recipients up to three decades after organ transplantation implies the migration and survival of donor stem cells within the host.
Demetris, AJ, Lu, L, Murase, N, Rao, AS, Starzl, TE, Thomson, AW   +5 more
core   +1 more source

Triggers of Autoimmunity: The Role of Bacterial Infections in the Extracellular Exposure of Lupus Nuclear Autoantigens

Frontiers in Immunology, 2019
Infections are considered important environmental triggers of autoimmunity and can contribute to autoimmune disease onset and severity. Nucleic acids and the complexes that they form with proteins—including chromatin and ribonucleoproteins—are the main ...
Connie C. Qiu, Roberto Caricchio, Stefania Gallucci   +2 more
doaj   +1 more source

Quantification of dendritic cell subsets in human thymus tissues of various ages

Immunity & Ageing, 2021
Background Dendritic cells (DCs) in the thymus are involved in central tolerance formation, but they also have other functions in the thymus, such as pathogen recognition. The density changes of human thymic DCs have been hardly investigated.
Yan Li, Pei Chen, Hao Huang, Huiyu Feng, Hao Ran, Weibin Liu   +5 more
doaj   +1 more source

Antigen presenting capacity of murine splenic myeloid cells [PDF]

, 2017
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying, O'Neill, Helen C, Quah, Benjamin   +2 more
core   +2 more sources

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

Nature Communications
Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and ...
Ahmed E. I. Hamouda, Jessica Filtjens, Elisabeth Brabants, Daliya Kancheva, Ayla Debraekeleer, Jan Brughmans, Lotte Jacobs, Pauline M. R. Bardet, Elisabeth Knetemann, Pierre Lefesvre, Lize Allonsius, Mark Gontsarik, Ismael Varela, Marian Crabbé, Emile J. Clappaert, Federica Cappellesso, Aarushi A. Caro, Alícia Gordún Peiró, Luna Fredericq, Eva Hadadi, Mariona Estapé Senti, Raymond Schiffelers, Leo A. van Grunsven, Frank Aboubakar Nana, Bruno G. De Geest, Sofie Deschoemaeker, Stefaan De Koker, Florence Lambolez, Damya Laoui   +28 more
doaj   +1 more source

Branching dendrites with resonant membrane: a “sum-over-trips” approach [PDF]

, 2007
Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons.
A Mauro, A Ooyen van, A Scott, AJ Hudspeth, B Hutcheon, B Hutcheon, BJ Cao, C Koch, C Koch, C. -M. Svensson, C. M. Colbert, D Johnson, EG Butz, G. J. Lord, HC Pape, HC Tuckwell, I Segev, JC Magee, JD Evans, JD Evans, K. Josić, LF Abbott, LF Abbott, M Häusser, M London, M London, M Migliore, MHP Kole, NT Carnevale, S. Coombes, S. J. Cox, SJ Cox, SJ Cox, X Li, Y Timofeeva, Y Timofeeva, Y. Timofeeva, ZF Mainen   +37 more
core   +3 more sources