Results 211 to 220 of about 5,310,926 (308)

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Dendritic Cells as Immunometabolic Regulatory Nodes in Diabetes: Molecular Mechanisms and Therapeutic Reprogramming. [PDF]

Int J Mol Sci
Jin F, Wu W, Yang X, Fan X, Zhao X, Liu W, Fan X.   +6 more
europepmc   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Priming of CD8⁺ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration. [PDF]

Nat Neurosci
Hu H, Lin PB, Zeng C, Li Y, Bosch ME, Emmerson JT, Sharma P, Ohara RA, Dong W, Wu T, Du S, Gao W, Jiang H, Yuan L, Bao X, Li S, Vomund AN, Erdmann-Gilmore P, Gu Y, Hu M, Nulman J, Miller TM, Yokoyama WM, Lichti CF, Milbrandt J, Perrin RJ, Kipnis J, Artyomov MN, Murphy KM, Ulrich JD, Holtzman DM.   +30 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Siglec-1-targeting single domain antibodies block or enhance pathogen binding to dendritic cells. [PDF]

J Biol Chem
Brink HJ, Affandi AJ, Man S, Dekker NCCT, Großewichtrup EA, Bouma RG, Toutounchi NS, Konijn VAL, Stolwijk JGC, van Hamme JL, Olesek K, Heijnen DAM, Fish A, Moutsiopoulou A, Celie PHN, Dekkers G, Heukers R, Mastrobattista E, Smit MJ, van Kooyk Y, van Gils MJ, Heikema AP, Kootstra NA, Geijtenbeek TBH, den Haan JMM.   +24 more
europepmc   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

Siglec-1-targeted nanobodies restrict HIV-1 transmission and infection of dendritic cells. [PDF]

J Virol
Man S, Affandi AJ, Brink HJ, van Hamme JL, Konijn VAL, Stolwijk JGC, den Haan JMM, Kootstra NA, Geijtenbeek TBH.   +8 more
europepmc   +1 more source