Results 101 to 110 of about 221,816 (215)
Notch1 Sigaling in Pyramidal Neurons regulates Synaptic Connectivity and Experience-Dependant Modifications of acuity in the Visual Cortex [PDF]
, 2008 How the visual cortex responds to specific stimuli is strongly influenced by visual experience during development. Monocular deprivation, for example, changes the likelihood of neurons in the visual cortex to respond to input from the deprived eye and ...
Dahlhaus, M. +7 more
core +1 more source
Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.This review summarizes the main uptake pathways of bioactive glass nanoparticles (BGNs) and their intracellular localization, highlighting that BGNs are mainly internalized and entrapped within endosomes/lysosomes. Strategies for controlled intracellular ion release, with implications for targeted modulation of cell behavior, are discussed. The need to
Andrada‐Ioana Damian‐Buda +1 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 2, 14 January 2026.A robust heparin‐mimicking coating based on sulfated polyglycerol is constructed via layer‐by‐layer assembly on bloodcontacting surfaces. The coating exhibits long‐term anticoagulant and anti‐inflammatory properties by resisting protein adsorption, preventing platelet activation, and suppressing immune responses, offering a promising strategy for ...
Kunpeng Liu +3 more
wiley +1 more source
ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons
iScience, 2019 Summary: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease characterized by motor neuron cell death. However, not all motor neurons are equally susceptible.
Zachary Osking +10 more
doaj +1 more source
α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons. [PDF]
PLoS ONE, 2014 Dendritic spines are micron-sized protrusions that constitute the primary post-synaptic sites of excitatory neurotransmission in the brain. Spines mature from a filopodia-like protrusion into a mushroom-shaped morphology with a post-synaptic density (PSD)
Jennifer L Hodges +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Autism spectrum disorder (ASD) has a broad range of neurobiological characteristics, including alterations in dendritic spines, where approximately 90% of excitatory synapses occur.
Isabel Barón-Mendoza +5 more
doaj +1 more source
WH2 and proline-rich domains of WASP-family proteins collaborate to accelerate actin filament elongation. [PDF]
, 2017 WASP-family proteins are known to promote assembly of branched actin networks by stimulating the filament-nucleating activity of the Arp2/3 complex.
Akin, Orkun +6 more
core +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Advanced Science, Volume 13, Issue 6, 30 January 2026.Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu +13 more
wiley +1 more source
Frontiers in Neuroscience, 2019 Fragile X syndrome (FXS) is a neurodevelopmental disorder that causes intellectual disability, as well as the leading monogenic cause of autism spectrum disorders (ASD), in which neurons show aberrant dendritic spine structure.
Ke Cheng +20 more
doaj +1 more source