Results 111 to 120 of about 221,816 (215)
Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. [PDF]
, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Ahn, Jee-Yin +9 more
core +2 more sources
Advanced Science, Volume 13, Issue 5, 27 January 2026.This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen +5 more
wiley +1 more source
The organisation and functions of local Ca2+ signals [PDF]
, 2001 Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation.
Berridge, Michael J. +2 more
core
Top‐Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains
Journal of Mass Spectrometry, Volume 61, Issue 1, January 2026.ABSTRACT Aging significantly impacts brain function and increases susceptibility to neurodegenerative diseases, with notable sex dimorphism observed in aging‐related dementia, such as Alzheimer's disease. To better understand the molecular mechanisms of aging and dementia, it is essential to globally and accurately characterize biomolecules (e.g ...
Mehrdad Falamarzi Askarani +6 more
wiley +1 more source
Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers
Aging Cell, Volume 25, Issue 1, January 2026.We integrated human data of aging‐related reductions in inhibition, NMDA function, and dendritic spines into detailed models of cortical microcircuits. Simulations showed that the cellular aging mechanisms accounted for many of the age‐related changes seen in human EEG and could be estimated accurately using machine learning from their EEG biomarkers ...
Alexandre Guet‐McCreight +3 more
wiley +1 more source
Imaging high-resolution structure of GFP-expressing neurons in neocortex in vivo [PDF]
, 2000 To detect subtle changes in neuronal morphology in response to changes in experience, one must image neurons at high resolution in vivo over time scales of minutes to days.
Burbach, B. +5 more
core +1 more source
The FEBS Journal, Volume 293, Issue 1, Page 26-41, January 2026.Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou +6 more
wiley +1 more source
Altered expression of neuroplasticity-related genes in the brain of depressed suicides [PDF]
, 2015 Background: Expression of the neuronal membrane glycoprotein M6a (GPM6A), the proteolipid protein (PLP/DM20) family member, is downregulated in the hippocampus of chronically stressed animals.
Alvarez Juliá, Anabel +4 more
core +1 more source
Frontiers in Cellular Neuroscience, 2018 DPP6 is well known as an auxiliary subunit of Kv4-containing, A-type K+ channels which regulate dendritic excitability in hippocampal CA1 pyramidal neurons.
Lin Lin +8 more
doaj +1 more source
Striatal Morphological and Functional Alterations Induced by Prenatal Alcohol Exposure [PDF]
, 2019 Prenatal alcohol exposure (PAE) is an insidious yet preventable cause of developmental disability. The prenatal stage is a critical period for brain development with the concurrence of high vulnerability to the acute and prolonged effects of PAE.
Ma, Yao-Ying
core +1 more source