Results 121 to 130 of about 221,816 (215)

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin

Biology Open, 2015
ICAM-5 is a negative regulator of dendritic spine maturation and facilitates the formation of filopodia. Its absence results in improved memory functions, but the mechanisms have remained poorly understood.
Lin Ning, Sonja Paetau, Henrietta Nyman-Huttunen, Li Tian, Carl G. Gahmberg   +4 more
doaj   +1 more source

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule. [PDF]

, 2013
International ...
Briault, Sylvain, Cahard, Dominique, Crusio, Wim ,, Doisne, Nicolas, Got, Laurence, Hébert, Betty, Laudier, Béatrice, Laugeray, Anthony, Laumonnier, Frédéric, Lefeuvre, Sandrine, Menuet, Arnaud, Même, Sandra, Perche, Olivier, Pichon, Jacques, Pietropaolo, Susanna, Quartier, Angélique   +15 more
core   +5 more sources

A Versatile AIEgen for In Situ Monitoring of Entire ApoVs Formation Processes

Aggregate, Volume 6, Issue 12, December 2025.
This work developed a versatile AIEgen for in situ monitoring of the entire ApoVs formation processes, and demonstrated that ApoVs originate from plasma‐membrane protrusions. ABSTRACT Apoptotic vesicles (ApoVs) are membrane structures formed during cell apoptosis and play crucial roles in homeostasis maintenance, signal transduction, and immune ...
Qiuhua Hao, Nan Sheng, Jie Niu, Chi Li, Fangfang Meng, Xingyu Lyu, Jiaxuan Wang, Zhiqiang Liu, Xiaoqiang Yu   +8 more
wiley   +1 more source

Huntingtin-Interacting Protein 1-Related Protein Plays a Critical Role in Dendritic Development and Excitatory Synapse Formation in Hippocampal Neurons

Frontiers in Molecular Neuroscience, 2017
Huntingtin-interacting protein 1-related (HIP1R) protein is considered to be an endocytic adaptor protein like the other two members of the Sla2 family, Sla2p and HIP1.
Lin Peng, Qian Yang, Xingxing Xu, Yonglan Du, Yu Wu, Xiaofang Shi, Junyu Xu, Lijun Zhu, Jianhong Luo   +8 more
doaj   +1 more source

Interaction of human mesenchymal stem cells with soft nanocomposite hydrogels based on polyethylene glycol and dendritic polyglycerol [PDF]

, 2019
Keeping the stemness of human mesenchymal stem cells (hMSCs) and their adipocyte differentiation potential is critical for clinical use. However, these features are lost on traditional substrates.
Camacho, José Luis Cuellar, Haag, Rainer, Hou, Yong, Kulka, Michaël W., Pan, Yuanwei, Randriantsilefisoa, Rotsiniaina, Zhang, Jianguang   +6 more
core   +1 more source

Actin-binding proteins and signalling pathways associated with the formation and maintenance of dendritic spines

Neurología (English Edition), 2012
Introduction: The dendritic spines are the main sites of excitatory synaptic contacts. Moreover, they present plastic responses to different stimuli of synaptic activity or damage, ranging from an increase or decrease in its total number, or a ...
C. Soria Fregozo, M.I. Pérez Vega
doaj   +1 more source

Participación de las proteínas de unión a la actina y vías de señalización asociadas a la formación y mantenimiento de las espinas dendríticas

Neurología, 2012
Resumen: Introducción: Las espinas dendríticas representan los principales sitios de contactos sinápticos de tipo excitador. Además, presentan respuestas plásticas a diferentes estímulos propios de la actividad sináptica o daño, que van de un aumento o ...
C. Soria Fregozo, M.I. Pérez Vega
doaj   +1 more source

Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c [PDF]

, 2016
Cortico-basal ganglia circuits are critical for speech and language and are implicated in autism spectrum disorder, in which language function can be severely affected.
A Di Martino, AC Barbosa, AN Sheth, Ann M Graybiel, BM Neale, BS Abrahams, CC, Ouimet, Cheng-Ting Chien, DH Ebert, E Hollander, E Spiteri, EM Morrow, F Novara, F Tronche, F Vargha-Khadem, Fu-Chin Liu, GM Sia, Gui-May Chen, H Li, Hao-Yu Yang, Hiroshi Takahashi, Hsiao-Ying Kuo, HY Zoghbi, J Stenman, Jing-Ruei Lin, JR Crittenden, KE Watkins, KM Harris, KM Lu, Kuan-Ming Lu, LK Nisenbaum, M Adachi, M Chahrour, M Groszer, M Mody, MW Akhtar, N Le Meur, NP Tsai, P Roll, P Somogyi, RT Fremeau Jr., S Haesler, S Li, S Pulipparacharuvil, SA Graham, SA Lipton, SB Schulz, SC Vernes, Shih-Yun Chen, Sin-Jhong Cheng, SL Chang, Svante Pääbo, SW Flavell, T, Kaoru, Ulrich Bornschein, V Pawlak, W Enard, W Shu, Wolfgang Enard, Wulf Hevers, X Tian, Yi-Chuan Chen, Yi-Hsin Lee, Yun-Chia Chou, Z Mukamel   +64 more
core   +2 more sources

Characterization of dendritic morphology and neurotransmitter phenotype of thoracic descending propriospinal neurons after complete spinal cord transection and GDNF treatment [PDF]

, 2016
After spinal cord injury (SCI), poor regeneration of damaged axons of the central nervous system (CNS) causes limited functional recovery. This limited spontaneous functional recovery has been attributed, to a large extent, to the plasticity of ...
Chen, Chen, Deng, Lingxiao, Frye, Christian Corbin, Jin, Xiaoming, Jones, Kathryn, Ruan, Yiwen, Sengelaub, Dale, Xiong, Wenhui, Xu, Xiao-Ming   +8 more
core   +2 more sources