Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1 [PDF]
The Journal of Neuroscience, 1998 To determine the role of dendritic filopodia in the genesis of excitatory synaptic contacts and dendritic spines in hippocampal area CA1, serial section electron microscopy and three-dimensional analysis of 16 volumes of neuropil from nine male rat pups,
John C. Fiala +3 more
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Molecular mechanisms shaping the actin filament scaffold of dendritic filopodia [PDF]
Biological ChemistryDendritic spines are the postsynaptic compartment of most excitatory synapses in the vertebrate brain. Their morphology is defined by a complex actin scaffold consisting of branched and unbranched actin filaments (F-actin), which constitute the major ...
Marco B. Rust, Sharof Khudayberdiev
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Mobilization of HIV spread by diaphanous 2 dependent filopodia in infected dendritic cells. [PDF]
PLoS Pathogens, 2012 Paramount to the success of persistent viral infection is the ability of viruses to navigate hostile environments en route to future targets. In response to such obstacles, many viruses have developed the ability of establishing actin rich-membrane ...
Anupriya Aggarwal +6 more
doaj +5 more sources
Activity-Regulated Dynamic Behavior of Early Dendritic Protrusions: Evidence for Different Types of Dendritic Filopodia [PDF]
The Journal of Neuroscience, 2003 Dendritic filopodia are long and thin protrusions that occur predominantly during early development of the mammalian CNS. The function of dendritic filopodia is unknown, but they could serve to form early synapses, to generate spines, or to regulate dendritic branching and growth.
Carlos Portera‐Cailliau +2 more
semanticscholar +4 more sources
Coincident Pre- and Postsynaptic Activation Induces Dendritic Filopodia via Neurotrypsin-Dependent Agrin Cleavage [PDF]
Cell, 2009 The synaptic serine protease neurotrypsin is essential for cognitive function, as its deficiency in humans results in severe mental retardation. Recently, we demonstrated the activity-dependent release of neurotrypsin from presynaptic terminals and proteolytical cleavage of agrin at the synapse.
Kazumasa Matsumoto +12 more
semanticscholar +4 more sources
Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation [PDF]
Neuron, 1996 Axo-dendritic synaptogenesis was examined in live hippocampal cell cultures using the fluorescent dyes DiO to label dendrites and FM 4-64 to label functional presynaptic boutons. As the first functional synaptic boutons appeared in these cultures, numerous filopodia (up to 10 micron long) were observed to extend transiently (mean lifetime 9.5 min) from
Noam Ziv, Stephen J Smith
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Modeling Actomyosin Contractility in Motile Dendritic Filopodia Resolves Spine Shape in Mature Dendritic Spines [PDF]
Biophysical Journal, 2012 Dendritic spines of hippocampal neurons are receivers of neurotransmission input that occurs during learning and memory.Dendritic spines stabilization and their structural plasticity underlie synaptogenesis and synaptic plasticity. The morphology and motility of dendritic spines and their precursors, dendritic filopodia, depend crucially on the ...
Olena Marchenko, Charles W. Wolgemuth
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A Role for Local Calcium Signaling in Rapid Synaptic Partner Selection by Dendritic Filopodia [PDF]
Neuron, 2008 Synapse elimination is an important process underlying the establishment of functional neuronal networks during development. Here, we tested the idea that neurons select among potential synaptic partners already during initial contact formation between dendritic filopodia and axons-well before mature synapses are established.
Christian Löhmann, Tobias Bonhoeffer
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Drebrin-Dependent Actin Clustering in Dendritic Filopodia Governs Synaptic Targeting of Postsynaptic Density-95 and Dendritic Spine Morphogenesis [PDF]
The Journal of Neuroscience, 2003 Dendritic spines have two major structural elements: postsynaptic densities (PSDs) and actin cytoskeletons. PSD proteins are proposed to regulate spine morphogenesis. However, other molecular mechanisms should govern spine morphogenesis, because the initiation of spine morphogenesis precedes the synaptic clustering of these proteins. Here, we show that
Hideto Takahashi +5 more
semanticscholar +5 more sources
The Effects of Activity of Astrocytes on Neuron Dendritic Filopodia Motility* [PDF]
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2011 Pu-Qing LIU, Keqing Zhu
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