Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures [PDF]
Neuroscience, 2009 The transmembrane isoform of agrin (Tm-agrin) is the predominant form expressed in the brain but its putative roles in brain development are not well understood. Recent reports have implicated Tm-agrin in the formation and stabilization of filopodia on neurites of immature central and peripheral neurons in culture.
Seumas McCroskery +3 more
semanticscholar +4 more sources
Sodium channel b2 subunit promotes filopodia-like processes and expansion of the dendritic tree in developing rat hippocampal neurons [PDF]
Frontiers in Cellular Neuroscience, 2013 The b2 auxiliary subunit of voltage gated sodium channels (VGSCs) appears at early stages of brain development. It is abundantly expressed in the mammalian central nervous system where it forms complexes with different channel isoforms, including Nav1.2.
Marta eMaschietto +5 more
doaj +2 more sources
Localization of a β-Actin Messenger Ribonucleoprotein Complex with Zipcode-Binding Protein Modulates the Density of Dendritic Filopodia and Filopodial Synapses [PDF]
Journal of Neuroscience, 2003 The dendritic transport and local translation of mRNA may be an essential mechanism to regulate synaptic growth and plasticity. We investigated the molecular mechanism and function of β-actin mRNA localization in dendrites of cultured hippocampal neurons.
Taesun Eom +3 more
openalex +2 more sources
Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells [PDF]
Immunity & Ageing, 2012 Background We recently isolated and identified Zizimin2 as a functional factor that is highly expressed in murine splenic germinal center B cells after immunization with T-cell-dependent antigen.
Sakabe Isamu +3 more
doaj +2 more sources
Developmental relocation of presynaptic terminals along distinct types of dendritic filopodia
Developmental Biology, 2006 Dendritic filopodia are long thin protrusions occurring predominantly on developing neurons. Data from different systems suggest a range of crucial functions for filopodia in central circuit formation, including steering of dendritic growth, branch formation, synaptogenesis, and spinogenesis.
Jan Felix Evers, D. Muench, Carsten Duch
semanticscholar +4 more sources
The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning [PDF]
eLife, 2017 Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood.
Jie Gao +9 more
doaj +5 more sources
Mechanosensing in Dendritic Cells. [PDF]
Immunol RevABSTRACT Since their discovery, dendritic cells have been recognized for their unusual capacity to sense and respond to physical stimuli within their environment. However, it took nearly two decades—and the advent of mechanobiology—to elucidate the underlying mechanisms and functional implications of this mechanical hypersensitivity. In this review, we
Calmettes V +5 more
europepmc +2 more sources
Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis [PDF]
Nature Communications, 2018 During development, dendrites display structural plasticity, as reflected in the appearance of long, thin and highly motile dendritic filopodia. Here, the authors examine dendritic dynamics of ventral lateral neurons in the developing Drosophila larva ...
Chengyu Sheng +6 more
doaj +3 more sources
Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure [PDF]
Behavioral and Brain FunctionsBackground Nicotine dependence is associated with glutamatergic neurotransmission in the caudate and putamen (CPu) of the forebrain which includes alterations in the structure of dendritic spines at glutamate synapses.
Sunghyun Kim, Sumin Sohn, Eun Sang Choe
doaj +2 more sources
LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice. [PDF]
J NeurosciLeucine zipper protein 1 (LUZP1) functions in the maintenance and dynamics of the cytoskeleton by interacting with actin and microtubules. Deficiency or mutation of LUZP1 is associated with brain developmental disorders; however, its precise role in ...
Wang X +12 more
europepmc +2 more sources