Mechanism of filopodia initiation by reorganization of a dendritic network [PDF]
The Journal of Cell Biology, 2003 Afilopodium protrudes by elongation of bundled actin filaments in its core. However, the mechanism of filopodia initiation remains unknown. Using live-cell imaging with GFP-tagged proteins and correlative electron microscopy, we performed a kinetic-structural analysis of filopodial initiation in B16F1 melanoma cells.
Tatyana Svitkina +6 more
openalex +3 more sources
H-Ras induces exuberant de novo dendritic protrusion growth in mature neurons regardless of cell type [PDF]
iScienceSummary: Dendritic protrusions, mainly spines and filopodia, correlate with excitatory synapses in pyramidal neurons (PyNs), but this relationship may not apply universally.
Sarah Krüssel +7 more
doaj +2 more sources
Nanoscale topological mapping of filopodia in live dendritic cells
Biophysical Journal, 2022 Haoran Jing
semanticscholar +2 more sources
Formation of filopodia-like bundles in vitro from a dendritic network [PDF]
The Journal of Cell Biology, 2003 We report the development and characterization of an in vitro system for the formation of filopodia-like bundles. Beads coated with actin-related protein 2/3 (Arp2/3)–activating proteins can induce two distinct types of actin organization in cytoplasmic extracts: (1) comet tails or clouds displaying a dendritic array of actin filaments and (2) stars ...
Danijela Matic Vignjevic +5 more
openalex +3 more sources
Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. [PDF]
, 2014 The earliest stages of Alzheimer's disease (AD) are characterized by deficits in memory and cognition indicating hippocampal pathology. While it is now recognized that synapse dysfunction precedes the hallmark pathological findings of AD, it is unclear ...
Antonios, Joseph K +6 more
core +17 more sources
The role of dendritic filopodia in postembryonic remodelling of dendritic architecture
, 2005 Diese Dissertation besteht aus zwei thematisch zusammenhängenden Teilen. Im ersten Teil beschreibe ich die Entwicklung von Methoden, die es erlauben, genaue geometrische Rekonstruktionen des Verzeigungsmusters anhand von Neuronen von 3-dimensionalen Bilderstapeln zu erstellen, die mit Hilfe der konfokalen Mikroskopie aufgenommen wurden.
Jan Felix Evers
openalex +3 more sources
CRP1, a Protein Localized in Filopodia of Growth Cones, Is Involved in Dendritic Growth [PDF]
The Journal of Neuroscience, 2011 The cysteine-rich protein (CRP) family is a subgroup of LIM domain proteins. CRP1, which cross-links actin filaments to make actin bundles, is the only CRP family member expressed in the CNS with little known about its function in nerve cells. Here, we report that CRP1 colocalizes with actin in the filopodia of growth cones in cultured rat hippocampal ...
Liping Ma +2 more
openalex +4 more sources
Regulation of dendritic filopodial interactions by ZO-1 and implications for dendrite morphogenesis. [PDF]
PLoS ONE, 2013 Neuronal dendrites dynamically protrude many fine filopodia in the early stages of neuronal development and gradually establish complex structures. The importance of the dendritic filopodia in the formation of axo-dendritic connections is established ...
Ryouhei Komaki +2 more
doaj +1 more source
bioRxiv, 2021 Dendritic spines are the postsynaptic compartment of a functional neuronal synapse, and are critical for synaptic connectivity and plasticity. The developmental precursor to dendritic spines, dendritic filopodia, are highly motile protrusions that ...
SS Parker +9 more
semanticscholar +1 more source
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. [PDF]
Nat ImmunolHolley CL +20 more
europepmc +3 more sources