Anesthetic Sevoflurane Causes Rho-Dependent Filopodial Shortening in Mouse Neurons. [PDF]
PLoS ONE, 2016 Early postnatal anesthesia causes long-lasting learning and memory impairment in rodents, however, evidence for a specific neurotoxic effect on early synaptogenesis has not been demonstrated.
Jeffrey H Zimering +5 more
doaj +1 more source
Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor [PDF]
Journal of Cell Science, 2004 The Trk family of receptor tyrosine kinases and the p75 receptor (p75NTR) mediate the effects of neurotrophins on neuronal survival, differentiation and synaptic plasticity. The neurotrophin BDNF and its cognate receptor tyrosine kinase, TrkB.FL, are highly expressed in neurons of the central nervous system. At later stages in postnatal development the
Matthias Hartmann +6 more
semanticscholar +3 more sources
Actin capping protein regulates postsynaptic spine development through CPI-motif interactions
Frontiers in Molecular Neuroscience, 2022 Dendritic spines are small actin-rich protrusions essential for the formation of functional circuits in the mammalian brain. During development, spines begin as dynamic filopodia-like protrusions that are then replaced by relatively stable spines ...
Kenneth R. Myers +6 more
doaj +1 more source
Combinatorial morphogenesis of dendritic spines and filopodia by SPAR and α-actinin2 [PDF]
Biochemical and Biophysical Research Communications, 2009 Rap small GTPases regulate excitatory synaptic strength and morphological plasticity of dendritic spines. Changes in spine structure are mediated by the F-actin cytoskeleton, but the link between Rap activity and actin dynamics is unclear. Here, we report a novel interaction between SPAR, a postsynaptic inhibitor of Rap, and alpha-actinin, a family of ...
Hyang-Sook Hoe +2 more
openalex +3 more sources
Calcium Sensors STIM1 and STIM2 Regulate Different Calcium Functions in Cultured Hippocampal Neurons
Frontiers in Synaptic Neuroscience, 2021 There are growing indications for the involvement of calcium stores in the plastic properties of neurons and particularly in dendritic spines of central neurons.
Liliya Kushnireva +4 more
doaj +1 more source
Transient Effects of Anesthetics on Dendritic Spines and Filopodia in the Living Mouse Cortex [PDF]
Anesthesiology, 2011 Background Anesthetics are widely used to induce unconsciousness, pain relief, and immobility during surgery. It remains unclear whether the use of anesthetics has significant and long-lasting effects on synapse development and plasticity in the brain. To address this question, the authors examined the formation
Guang Yang +4 more
openalex +4 more sources
Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology. [PDF]
PLoS ONE, 2011 Dendritic spines in hippocampal neurons mature from a filopodia-like precursor into a mushroom-shape with an enlarged post-synaptic density (PSD) and serve as the primary post-synaptic location of the excitatory neurotransmission that underlies learning ...
Jennifer L Hodges +4 more
doaj +1 more source
A two-step actin polymerization mechanism drives dendrite branching
Neural Development, 2021 Background Dendrite morphogenesis plays an essential role in establishing the connectivity and receptive fields of neurons during the development of the nervous system. To generate the diverse morphologies of branched dendrites, neurons use external cues
Rebecca Shi +3 more
doaj +1 more source
In Vivo Study of Dynamics and Stability of Dendritic Spines on Olfactory Bulb Interneurons in Xenopus laevis Tadpoles. [PDF]
PLoS ONE, 2015 Dendritic spines undergo continuous remodeling during development of the nervous system. Their stability is essential for maintaining a functional neuronal circuit.
Yu-Bin Huang +4 more
doaj +1 more source
Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]
, 2016 During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo +5 more
core +2 more sources