Results 51 to 60 of about 221,816 (215)

A Dynamin-3 Spliced Variant Modulates the Actin/Cortactin-Dependent Morphogenesis of Dendritic Spines [PDF]

, 2005
Immature dendrites extend many actin-rich filopodial structures that can be replaced by synapse-containing dendritic spines as the neuron matures. The large GTPase dynamin-3 (Dyn3) is a component of the postsynapse in hippocampal neurons but its function
Chen, Jing, Gray, Noah W., Kruchten, Anne E., McNiven, Mark A.   +3 more
core   +2 more sources

Wnt signaling in synaptogenesis of Alzheimer's disease

Ibrain, 2023
Alzheimer's disease (AD), recognized as the leading cause of dementia, occupies a prominent position on the list of significant neurodegenerative disorders, representing a significant global health concern with far‐reaching implications at both ...
Cheng‐Ting Zhang, Joy Wang, Wen‐Yuan Wang   +2 more
doaj   +1 more source

AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats [PDF]

, 2020
© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Glioblastoma is a kind of malignant tumour and originates from the central nervous system.
Bankier, Barkal, Barria, Benros, Braganhol, Campos-Pires, Chen, Cheong, Chicoine, Crossen, D'Alessandris, d'Isa, da Silva, Dalton, Del Sol-Fernandez, Ferrandon, Froklage, Gong, Graf, Graus, Guogang Ren, Hao, Hara, He, Heppner, Hilverda, Hwang, Jacob, Janelsins, Ji, Jin Gao, Junyang Li, Lang, Liang, Limin Wu, Liu, McFarland, Meicen Liu, Meng, Mineharu, Mostofa, Murata, Myung, Nagano, Nan, Nan, Noy, Oh, Ohgaki, Okada, Ostrom, Ovais, Park, Parrott, Platten, Quant, Reichel, Reid, Ren, Ren, Ren, Saalik, Shan, Sholl, Sim, Solanki, Sorensen, Sorra, Spacek, Stupp, Stupp, Tanaka, Thompson, Thorsson, Van Dyk, Vecht, Venkatesh, Walker, Walker Ii, Wan, Wang, Wang, Weitzner, Williams, Woodward, Wu, Wu, Yang, Yang, Yang, Yang, Yu, Yu Jiang, Yuen-Ki Cheong, Zhang, Zhu, Zhuo Yang, Zong, Zou   +98 more
core   +2 more sources

Dendritic Spine Shape Analysis: A Clustering Perspective [PDF]

, 2016
Functional properties of neurons are strongly coupled with their morphology. Changes in neuronal activity alter morphological characteristics of dendritic spines.
A Govindarajan, A Lipson, A Peters, A Rodriguez, AK Jain, B Ruszczycki, CD Harvey, F Chang, F Mesadi, IY Koh, J Bourne, J Lippman, J Son, J Spacek, J Tonnesen, JB Tenenbaum, JI Arellano, JJ Mancuso, JW Wallis, M Matsuzaki, P Mitra, PT So, R Yuste, R Yuste, TF Chan, TM Cover, W Bai, W Wallace, X Xu, Y Zhang, Z Parnass   +30 more
core   +2 more sources

Arp2/3 complex activity in filopodia of spreading cells [PDF]

, 2008
Background Cells use filopodia to explore their environment and to form new adhesion contacts for motility and spreading. The Arp2/3 complex has been implicated in lamellipodial actin assembly as a major nucleator of new actin filaments in branched ...
Bramble, Jonathan P, Johnston, Simon A, Machesky, Laura M, Mendes, Paula M, Yeung, Chun L   +4 more
core   +4 more sources

Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. [PDF]

PLoS Biology, 2007
Actin polymerization-driven protrusion of the leading edge is a key element of cell motility. The important actin nucleators formins and the Arp2/3 complex are believed to have nonoverlapping functions in inducing actin filament bundles in filopodia and ...
Changsong Yang, Lubov Czech, Silke Gerboth, Shin-ichiro Kojima, Giorgio Scita, Tatyana Svitkina   +5 more
doaj   +1 more source

Gintonin stimulates dendritic growth in striatal neurons by activating Akt and CREB

Frontiers in Molecular Neuroscience, 2022
Gintonin, a glycolipid protein conjugated with lysophosphatidic acid (LPA), is a newly identified compound extracted from Korean ginseng. LPA receptor isotypes exhibit high affinity for gintonin and mediate intracellular calcium signaling in various ...
Hye Kyung Lim, Kitaek Kim, Youn Kyoung Son, Seung-Yeol Nah, Soo Min Ahn, Minseok Song   +5 more
doaj   +1 more source

Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study [PDF]

, 2018
Indexación: Scopus.Laboratory of Neuroplasticity and Neurogenetics, Department of Biochemistry and Molecular Biology, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile, 2Laboratorio Farmacología del Comportamiento ...
Ana M. Avalos, Ana M. Avalos, Aníbal Pacheco, Esteban Aliaga, Felipe Antonio Olave, Felipe Ignacio Aguayo, Gabriela Díaz-Véliz, Gonzalo García-Rojo, Jenny Lucy Fiedler, José L. Ulloa, Luciano Román-Albasini, Macarena Tejos-Bravo, Paulina S. Rojas, Wladimir Corrales   +13 more
core   +2 more sources

Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons

eLife, 2014
In the vertebrate central nervous system, exploratory filopodia transiently form on dendritic branches to sample the neuronal environment and initiate new trans-neuronal contacts.
Milos Galic, Feng-Chiao Tsai, Sean R Collins, Maja Matis, Samuel Bandara, Tobias Meyer   +5 more
doaj   +1 more source

Light-induced engagement of microglia to focally remodel synapses in the adult brain

eLife, 2020
Microglia continuously monitor synapses, but active synaptic remodeling by microglia in mature healthy brains is rarely directly observed. We performed targeted photoablation of single synapses in mature transgenic mice expressing fluorescent labels in ...
Carla Cangalaya, Stoyan Stoyanov, Klaus-Dieter Fischer, Alexander Dityatev   +3 more
doaj   +1 more source