Location-dependent synaptic plasticity rules by dendritic spine cooperativity
Nature Communications, 2016 Nonlinear interactions between coactive synapses enable neurons to discriminate between spatiotemporal patterns of inputs. Using patterned postsynaptic stimulation by two-photon glutamate uncaging, here we investigate the sensitivity of synaptic Ca2 ...
Jens P. Weber +5 more
semanticscholar +1 more source
Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology
Scientific Reports, 2016 Dendritic spines are the postsynaptic compartments of glutamatergic synapses in the brain. Their number and shape are subject to change in synaptic plasticity and neurological disorders including autism spectrum disorders and Parkinson’s disease.
R. Stanika +6 more
semanticscholar +1 more source
Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit [PDF]
, 2016 Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction.
Caioli, Silvia +5 more
core +1 more source
Journal of Neuroscience, 2016 Dendritic spines are a morphological feature of the majority of excitatory synapses in the mammalian neocortex and are motile structures with shapes and lifetimes that change throughout development.
Hyojin Kim +4 more
semanticscholar +1 more source
Diffusion laws in dendritic spines [PDF]
The Journal of Mathematical Neuroscience, 2011 Dendritic spines are small protrusions on a neuronal dendrite that are the main locus of excitatory synaptic connections. Although their geometry is variable over time and along the dendrite, they typically consist of a relatively large head connected to the dendritic shaft by a narrow cylindrical neck.
David Holcman, Zeev Schuss
openaire +2 more sources
Active elastohydrodynamics of vesicles in narrow, blind constrictions [PDF]
, 2017 Fluid-resistance limited transport of vesicles through narrow constrictions is a recurring theme in many biological and engineering applications. Inspired by the motor-driven movement of soft membrane-bound vesicles into closed neuronal dendritic spines,
Fai, Thomas G. +4 more
core +4 more sources
Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation*
Journal of Biological Chemistry, 2016 Wnt ligands play crucial roles in the development and regulation of synapse structure and function. Specifically, Wnt-5a acts as a secreted growth factor that regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic ...
Valerie T. Ramírez +4 more
semanticscholar +1 more source
Cell-Type Specific Changes in Glial Morphology and Glucocorticoid Expression During Stress and Aging in the Medial Prefrontal Cortex. [PDF]
, 2018 Repeated exposure to stressors is known to produce large-scale remodeling of neurons within the prefrontal cortex (PFC). Recent work suggests stress-related forms of structural plasticity can interact with aging to drive distinct patterns of pyramidal ...
Bruce S. McEwen +8 more
core +2 more sources
Remodeling dendritic spines for treatment of traumatic brain injury
Neural Regeneration Research, 2019 Traumatic brain injury is an important global public health problem. Traumatic brain injury not only causes neural cell death, but also induces dendritic spine degeneration. Spared neurons from cell death in the injured brain may exhibit dendrite damage,
Ye Xiong, Asim Mahmood, Michael Chopp
doaj +1 more source
Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities
Acta Neuropathologica, 2015 Synaptic failure is an immediate cause of cognitive decline and memory dysfunction in Alzheimer’s disease. Dendritic spines are specialized structures on neuronal processes, on which excitatory synaptic contacts take place and the loss of dendritic ...
M. Dorostkar +3 more
semanticscholar +1 more source