Journal of Neural Transplantation and Plasticity, 2015 Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate thedevelopment and maintenance of dendritic spines is limited.
Xiaohua Jin +7 more
semanticscholar +1 more source
Neural Plasticity, 2012 Activation of TrkB receptors by brain-derived neurotrophic factor (BDNF) followed by MAPK/ERK signaling increases dendritic spine density and the proportion of mature spines in hippocampal CA1 pyramidal neurons. Considering the opposing actions of p75NTR
Christopher A. Chapleau +1 more
doaj +1 more source
C. elegans neurons have functional dendritic spines
eLife, 2019 Dendritic spines are specialized postsynaptic structures that transduce presynaptic signals, are regulated by neural activity and correlated with learning and memory. Most studies of spine function have focused on the mammalian nervous system.
Andrea Cuentas-Condori +5 more
doaj +1 more source
Spatiotemporal modeling reveals geometric dependence of AMPAR dynamics on dendritic spine morphology
, 2022 Miriam Bell +2 more
openalex +1 more source
Actin cytoskeleton in dendritic spine
Folia Pharmacologica Japonica, 2007 樹状突起スパインは脳内の主要な興奮性シナプス後部であり，その形態および構成タンパク質の可塑的変化は学習記憶などの高次機能に重要である．スパイン内の構造体としては，シナプス後部肥厚（PSD）とアクチン細胞骨格があり，スパインの形態変化は主にアクチン細胞骨格により制御されている．スパイン内ではその頭部と頸部でアクチン線維の構造が異なることに加えて，頭部の中でもシナプス直下のPSD近傍と細胞質の中心領域でアクチン結合タンパク質の分布が異なる．したがって，スパインは3種類の性質の異なるアクチン細胞骨格によって構成されていると考えられる．アクチンを脱重合させると，多くのスパイン構成タンパク質の局在が不安定化し，スパイン形態もフィロポディア様に変化する．従って，アクチン細胞骨格がスパイン形態の形成 ...
Kenji, Hanamura, Tomoaki, Shirao
openaire +3 more sources
EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
eLife, 2019 Vascular endothelial growth factor (VEGF) is an angiogenic factor that play important roles in the nervous system, although it is still unclear which receptors transduce those signals in neurons.
Eva Harde +8 more
doaj +1 more source
Frontiers in Computational Neuroscience, 2017 The damage of dopaminergic neurons that innervate the striatum has been considered to be the proximate cause of Parkinson's disease (PD). In the dopamine-denervated state, the loss of dendritic spines and the decrease of dendritic length may prevent ...
Xiaohan Zhang +4 more
doaj +1 more source
Vitamin B1-deficient mice show impairment of hippocampus-dependent memory formation and loss of hippocampal neurons and dendritic spines: potential microendophenotypes of Wernicke–Korsakoff syndrome [PDF]
, 2016 Hiroyoshi Inaba +6 more
openalex +1 more source
RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum-induced Alzheimer’s disease-like rat model [PDF]
, 2020 Fei Han +8 more
openalex +1 more source
Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
Journal of Neuroscience, 1990 Gonadal steroids are known to influence hippocampal physiology in adulthood. It is presently unknown whether gonadal steroids influence the morphology of hippocampal neurons in the adult intact rat brain. In order to determine whether female sex hormones
E. Gould +3 more
semanticscholar +1 more source