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Annual Review of Physiology, 2009
Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
D Harshad, Bhatt +2 more
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Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regulated by a variety of gene products
D Harshad, Bhatt +2 more
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Microtubules, dendritic spines and spine apparatuses
Cell and Tissue Research, 1980Using techniques for enhanced microtubular preservation, including albumin pretreatment (Gray, 1975), occipital cortex of rats was studied electron microscopically at various ages of development. A close structural relationship was seen between microtubules, sacs of SER and the postsynaptic "thickening" in primordial spines and with the dense "plate ...
L E, Westrum +3 more
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Dendritic Spines and Pain Memory
The Neuroscientist, 2022Neuropathic pain is a debilitating form of pain arising from injury or disease of the nervous system that affects millions of people worldwide. Despite its prevalence, the underlying mechanisms of neuropathic pain are still not fully understood. Dendritic spines are small protrusions on the surface of neurons that play an important role in synaptic ...
Curtis A. Benson +5 more
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Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», 2022
Мозг осуществляет постоянное и чаще достаточно успешное приспособление организма к меняющимся условиям среды. Важнейшим структурно-функциональным проявлением этой приспособительной реакции мозга является адекватное ситуации изменение числа, внешней формы, внутреннего строения, скорости структурных перестроек, химического состава воспринимающих сигнал ...
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Мозг осуществляет постоянное и чаще достаточно успешное приспособление организма к меняющимся условиям среды. Важнейшим структурно-функциональным проявлением этой приспособительной реакции мозга является адекватное ситуации изменение числа, внешней формы, внутреннего строения, скорости структурных перестроек, химического состава воспринимающих сигнал ...
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Science, 2001
STKE Changes in the morphology of neuronal dendritic spines are correlated with changes in synaptic plasticity. The cell surface proteoglycan syndecan-2 is clustered at the surface of mature hippocampal neurons and is thought to regulate structural changes of the spines. Now Ethell et al.
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STKE Changes in the morphology of neuronal dendritic spines are correlated with changes in synaptic plasticity. The cell surface proteoglycan syndecan-2 is clustered at the surface of mature hippocampal neurons and is thought to regulate structural changes of the spines. Now Ethell et al.
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2014
Fragile X syndrome is a mental condition caused by the mutation in a single gene called the fragile X mental retardation 1 (FMR1) gene, which is found on the X chromosome. Fragile X syndrome is the most common inherited condition causing mental retardation. Fragile X syndrome can cause learning disabilities, severe mental incapacitation and even autism.
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Fragile X syndrome is a mental condition caused by the mutation in a single gene called the fragile X mental retardation 1 (FMR1) gene, which is found on the X chromosome. Fragile X syndrome is the most common inherited condition causing mental retardation. Fragile X syndrome can cause learning disabilities, severe mental incapacitation and even autism.
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Editorial:Exciting Dendritic Spines
The Open Neuroscience Journal, 2009The ability of a synapse to alter its strength based on use (synaptic plasticity) reigns as the basis of most cellular models of learning and memory [1]. However, if synaptic plasticity is king, then the dendritic spine is its kingdom. The dendritic spine, which houses the majority of excitatory synapses in the mammalian central nervous system, also ...
Chi W. Pak, James R. Bamburg
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Microtubule Dynamics in Dendritic Spines
2010Neuronal microtubules recently emerged as temporal and spatial regulators of dendritic spines, the major sites of excitatory synaptic input. By imaging microtubules in cultured mature primary hippocampal neurons using fluorescently tagged tubulin and microtubule plus-end binding (EB) protein EB3, dynamic microtubules were found to regularly depart from
Kapitein, Lukas +2 more
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Electrical properties of dendritic spines
Biophysical Journal, 2023Dendritic spines are small protrusions that mediate most of the excitatory synaptic transmission in the brain. Initially, the anatomical structure of spines has suggested that they serve as isolated biochemical and electrical compartments. Indeed, following ample experimental evidence, it is now widely accepted that a significant physiological role of ...
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