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Editorial:Exciting Dendritic Spines
The Open Neuroscience Journal, 2009The ability of a synapse to alter its strength based on use (synaptic plasticity) reigns as the basis of most cellular models of learning and memory [1]. However, if synaptic plasticity is king, then the dendritic spine is its kingdom. The dendritic spine, which houses the majority of excitatory synapses in the mammalian central nervous system, also ...
Chi W. Pak, James R. Bamburg
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Microtubule Dynamics in Dendritic Spines
2010Neuronal microtubules recently emerged as temporal and spatial regulators of dendritic spines, the major sites of excitatory synaptic input. By imaging microtubules in cultured mature primary hippocampal neurons using fluorescently tagged tubulin and microtubule plus-end binding (EB) protein EB3, dynamic microtubules were found to regularly depart from
Kapitein, Lukas +2 more
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Electrical properties of dendritic spines
Biophysical Journal, 2023Dendritic spines are small protrusions that mediate most of the excitatory synaptic transmission in the brain. Initially, the anatomical structure of spines has suggested that they serve as isolated biochemical and electrical compartments. Indeed, following ample experimental evidence, it is now widely accepted that a significant physiological role of ...
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Neurotrophic Factors and Dendritic Spines
2023Dendritic spines are highly dynamic structures that play important roles in neuronal plasticity. The morphologies and the numbers of dendritic spines are highly variable, and this diversity is correlated with the different morphological and physiological features of this neuronal compartment.
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Dendritic spine morphogenesis and plasticity
Journal of Neurobiology, 2005AbstractDendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts.
Lippman-Bell, Jocelyn, Dunaevsky, A.
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Dendritic spine formation and stabilization
Current Opinion in Neurobiology, 2009Formation, elimination and remodeling of excitatory synapses on dendritic spines represent a continuous process that shapes the organization of synaptic networks during development. The molecular mechanisms controlling dendritic spine formation and stabilization therefore critically determine the rules of network selectivity.
Yoshihara, Yoshihiro +2 more
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2010
A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on
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A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on
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1998
Dendritic spines, sometimes also called dendritic thorns, are tiny, specialized protoplasmic protuberances that cover the surface of many neurons. First described by Ramón y Cajal (1909; 1991) in light-microscopic studies of Golgi stained tissue, they are among the most striking subneuronal features of many neurons.
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Dendritic spines, sometimes also called dendritic thorns, are tiny, specialized protoplasmic protuberances that cover the surface of many neurons. First described by Ramón y Cajal (1909; 1991) in light-microscopic studies of Golgi stained tissue, they are among the most striking subneuronal features of many neurons.
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Molecular morphogens for dendritic spines
Trends in Neurosciences, 2002Three protein components of the postsynaptic density--Shank, Homer and SPAR--have been found to regulate the structural and molecular organization of dendritic spines. These new studies reveal linkages between receptor complexes, the actin cytoskeleton and signaling molecules that help shape spines.
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Dendritic spines and linear networks
Journal of Physiology-Paris, 2004The function of the cortical microcircuitry is still mysterious. Using a bottom-up analysis based on the biophysics and connectivity of cortical neurons, we propose the hypothesis that the neocortex is essentially a linear integrator of inputs. Dendritic spines would slow the neuron and contribute to linearize input summation.
Rafael, Yuste, Rochelle, Urban
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